Müller Glia maintain their regenerative potential despite degeneration in the aged zebrafish retina

Ageing is a significant risk factor for degeneration of the retina. Müller glia cells (MG) are key for neuronal regeneration, so harnessing the regenerative capacity of MG in the retina offers great promise for the treatment of age‐associated blinding conditions. Yet, the impact of ageing on MG rege...

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Veröffentlicht in:	Aging cell 2022-04, Vol.21 (4), p.e13597-n/a
Hauptverfasser:	Martins, Raquel R., Zamzam, Mazen, Tracey‐White, Dhani, Moosajee, Mariya, Thummel, Ryan, Henriques, Catarina M., MacDonald, Ryan B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age ageing Aging Animals Animals, Genetically Modified Cell Proliferation - physiology Danio rerio degeneration DNA damage Ependymoglial Cells Morphology Mueller cells Müller glia Neurodegeneration Neuroglia - metabolism Neuronal-glial interactions Neurons proliferation Proteins Regeneration Retina Retina - metabolism Risk factors Telomerase Tumor necrosis factor-TNF Variance analysis Yes-associated protein Zebrafish
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