Partial reprogramming strategy for intervertebral disc rejuvenation by activating energy switch

Rejuvenation of nucleus pulposus cells (NPCs) in degenerative discs can reverse intervertebral disc degeneration (IDD). Partial reprogramming is used to rejuvenate aging cells and ameliorate progression of aging tissue to avoiding formation of tumors by classical reprogramming. Understanding the eff...

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Veröffentlicht in:	Aging cell 2022-04, Vol.21 (4), p.e13577-n/a
Hauptverfasser:	Cheng, Feng, Wang, Chenggui, Ji, Yufei, Yang, Biao, Shu, Jiawei, Shi, Kesi, Wang, Lulu, Wang, Shaoke, Zhang, Yuang, Huang, Xianpeng, Zhou, Xiaopeng, Xia, Kaishun, Liang, Chengzhen, Chen, Qixin, Li, Fangcai
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Back pain Cellular Reprogramming cellular senescence Cytoskeleton Degeneration Degenerative disc disease DNA methylation Energy metabolism Extracellular matrix Fibroblasts Hexokinase Humans Intervertebral Disc - metabolism intervertebral disc degeneration Intervertebral Disc Degeneration - metabolism Intervertebral discs KLF4 protein Metabolism Myc protein Nucleus pulposus Nucleus Pulposus - metabolism nucleus pulposus cells Phenotypes Rejuvenation reprogramming Senescence Stem cells Surgery Tumors
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