Arterial Stiffness and Long-Term Risk of Health Outcomes: The Framingham Heart Study
Arterial stiffness increases with age and is associated with an increased risk of adverse outcomes on short-term follow-up (typically
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2022-05, Vol.79 (5), p.1045-1056 |
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| container_title | Hypertension (Dallas, Tex. 1979) |
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| creator | Vasan, Ramachandran S. Pan, Stephanie Xanthakis, Vanessa Beiser, Alexa Larson, Martin G. Seshadri, Sudha Mitchell, Gary F. |
| description | Arterial stiffness increases with age and is associated with an increased risk of adverse outcomes on short-term follow-up (typically |
| doi_str_mv | 10.1161/HYPERTENSIONAHA.121.18776 |
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We evaluated 7283 Framingham Study participants (mean age 50 years, 53% women) who underwent assessment of carotid-femoral pulse wave velocity (a marker of arterial stiffness) via applanation tonometry at one or more routine examinations. We used time-dependent Cox proportional hazards regression models to relate carotid-femoral pulse wave velocity to the incidence of health outcomes (updating carotid-femoral pulse wave velocity and all covariates at serial examinations).
On long-term follow-up (median 15 years; minimum-maximum, 0-20), participants developed cardiometabolic disease (hypertension [1255 events]; diabetes [381 events]), chronic kidney disease (529 events), dementia (235 events), cardiovascular disease (684 events) and its components (coronary heart disease [314 events], heart failure [191 events], transient ischemic attacks or stroke [250 events]), and death (1086 events). In multivariable-adjusted models, each SD increment in carotid-femoral pulse wave velocity was associated with increased risk of hypertension (hazard ratio [HR], 1.32 [95% CI, 1.21-1.44]), diabetes (HR, 1.32 [95% CI, 1.11-1.58]), chronic kidney disease (1.19 [95% CI, 1.05-1.34]), dementia (HR 1.27 [95% CI, 1.06-1.53]), cardiovascular disease (HR, 1.20 [95% CI, 1.06-1.36]) and its components (coronary heart disease, HR 1.37 [95% CI, 1.13-1.65]; transient ischemic attack/stroke, HR, 1.24 [95% CI, 1.00-1.53]), and death (HR, 1.29 [95% CI, 1.17-1.43]). The association with heart failure was borderline nonsignificant (HR, 1.21 [95% CI, 0.98-1.51],
=0.08).
Our prospective observations of a large community-based sample establish the long-term prognostic importance of arterial stiffness for multiple health outcomes.</description><identifier>ISSN: 0194-911X</identifier><identifier>ISSN: 1524-4563</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/HYPERTENSIONAHA.121.18776</identifier><identifier>PMID: 35168368</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Dementia ; Diabetes Mellitus ; Female ; Heart Failure - epidemiology ; Humans ; Hypertension ; Longitudinal Studies ; Male ; Middle Aged ; Prospective Studies ; Pulse Wave Analysis ; Renal Insufficiency, Chronic ; Risk Factors ; Stroke ; Vascular Stiffness</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2022-05, Vol.79 (5), p.1045-1056</ispartof><rights>Lippincott Williams & Wilkins</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5248-f15b7e4cac0a4beeeaf8b0ae25760b83fdbe056dbf184b2b6d446eb2ad79955b3</citedby><cites>FETCH-LOGICAL-c5248-f15b7e4cac0a4beeeaf8b0ae25760b83fdbe056dbf184b2b6d446eb2ad79955b3</cites><orcidid>0000-0001-7357-5970 ; 0000-0001-8551-7778 ; 0000-0001-5643-3145 ; 0000-0002-7352-621X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3685,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35168368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vasan, Ramachandran S.</creatorcontrib><creatorcontrib>Pan, Stephanie</creatorcontrib><creatorcontrib>Xanthakis, Vanessa</creatorcontrib><creatorcontrib>Beiser, Alexa</creatorcontrib><creatorcontrib>Larson, Martin G.</creatorcontrib><creatorcontrib>Seshadri, Sudha</creatorcontrib><creatorcontrib>Mitchell, Gary F.</creatorcontrib><title>Arterial Stiffness and Long-Term Risk of Health Outcomes: The Framingham Heart Study</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>Arterial stiffness increases with age and is associated with an increased risk of adverse outcomes on short-term follow-up (typically <10 years). Data regarding associations of arterial stiffness with health outcomes on longer-term follow-up are lacking.
We evaluated 7283 Framingham Study participants (mean age 50 years, 53% women) who underwent assessment of carotid-femoral pulse wave velocity (a marker of arterial stiffness) via applanation tonometry at one or more routine examinations. We used time-dependent Cox proportional hazards regression models to relate carotid-femoral pulse wave velocity to the incidence of health outcomes (updating carotid-femoral pulse wave velocity and all covariates at serial examinations).
On long-term follow-up (median 15 years; minimum-maximum, 0-20), participants developed cardiometabolic disease (hypertension [1255 events]; diabetes [381 events]), chronic kidney disease (529 events), dementia (235 events), cardiovascular disease (684 events) and its components (coronary heart disease [314 events], heart failure [191 events], transient ischemic attacks or stroke [250 events]), and death (1086 events). In multivariable-adjusted models, each SD increment in carotid-femoral pulse wave velocity was associated with increased risk of hypertension (hazard ratio [HR], 1.32 [95% CI, 1.21-1.44]), diabetes (HR, 1.32 [95% CI, 1.11-1.58]), chronic kidney disease (1.19 [95% CI, 1.05-1.34]), dementia (HR 1.27 [95% CI, 1.06-1.53]), cardiovascular disease (HR, 1.20 [95% CI, 1.06-1.36]) and its components (coronary heart disease, HR 1.37 [95% CI, 1.13-1.65]; transient ischemic attack/stroke, HR, 1.24 [95% CI, 1.00-1.53]), and death (HR, 1.29 [95% CI, 1.17-1.43]). The association with heart failure was borderline nonsignificant (HR, 1.21 [95% CI, 0.98-1.51],
=0.08).
Our prospective observations of a large community-based sample establish the long-term prognostic importance of arterial stiffness for multiple health outcomes.</description><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Dementia</subject><subject>Diabetes Mellitus</subject><subject>Female</subject><subject>Heart Failure - epidemiology</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Pulse Wave Analysis</subject><subject>Renal Insufficiency, Chronic</subject><subject>Risk Factors</subject><subject>Stroke</subject><subject>Vascular Stiffness</subject><issn>0194-911X</issn><issn>1524-4563</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkVFv0zAUhS0EYqXwF5B54yXFdmzH4QGpmjo6qVrRFiR4suzkuglL4mEnTPv3eOuYAEv2lXXPPT7yh9A7SlaUSvph-_3L5rLaXFyd7y_W2_WKMrqiqijkM7SggvGMC5k_RwtCS56VlH47Qa9i_EEI5ZwXL9FJLqhUuVQLVK3DBKEzPb6aOudGiBGbscE7Px6yCsKAL7t4jb3DWzD91OL9PNV-gPgRVy3gs2CGbjy0Zrjvhym5zM3da_TCmT7Cm8e6RF_PNtXpNtvtP5-frndZnUKqzFFhC-C1qYnhFgCMU5YYYKKQxKrcNRaIkI11VHHLrGw4l2CZaYqyFMLmS_Tp6Hsz2wGaGsYpmF7fhG4w4U570-l_O2PX6oP_pUtCSpoXyeD9o0HwP2eIkx66WEPfmxH8HDWTrMwVYelcovIorYOPMYB7eoYSfU9F_0dFJyr6gUqafft3zqfJPxiSgB8Ft75POOJ1P99C0O3Dl2uSFmdSZSwlISLdsrSpyn8D6I2cTg</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Vasan, Ramachandran S.</creator><creator>Pan, Stephanie</creator><creator>Xanthakis, Vanessa</creator><creator>Beiser, Alexa</creator><creator>Larson, Martin G.</creator><creator>Seshadri, Sudha</creator><creator>Mitchell, Gary F.</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7357-5970</orcidid><orcidid>https://orcid.org/0000-0001-8551-7778</orcidid><orcidid>https://orcid.org/0000-0001-5643-3145</orcidid><orcidid>https://orcid.org/0000-0002-7352-621X</orcidid></search><sort><creationdate>20220501</creationdate><title>Arterial Stiffness and Long-Term Risk of Health Outcomes: The Framingham Heart Study</title><author>Vasan, Ramachandran S. ; Pan, Stephanie ; Xanthakis, Vanessa ; Beiser, Alexa ; Larson, Martin G. ; Seshadri, Sudha ; Mitchell, Gary F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5248-f15b7e4cac0a4beeeaf8b0ae25760b83fdbe056dbf184b2b6d446eb2ad79955b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Dementia</topic><topic>Diabetes Mellitus</topic><topic>Female</topic><topic>Heart Failure - epidemiology</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Pulse Wave Analysis</topic><topic>Renal Insufficiency, Chronic</topic><topic>Risk Factors</topic><topic>Stroke</topic><topic>Vascular Stiffness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vasan, Ramachandran S.</creatorcontrib><creatorcontrib>Pan, Stephanie</creatorcontrib><creatorcontrib>Xanthakis, Vanessa</creatorcontrib><creatorcontrib>Beiser, Alexa</creatorcontrib><creatorcontrib>Larson, Martin G.</creatorcontrib><creatorcontrib>Seshadri, Sudha</creatorcontrib><creatorcontrib>Mitchell, Gary F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vasan, Ramachandran S.</au><au>Pan, Stephanie</au><au>Xanthakis, Vanessa</au><au>Beiser, Alexa</au><au>Larson, Martin G.</au><au>Seshadri, Sudha</au><au>Mitchell, Gary F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arterial Stiffness and Long-Term Risk of Health Outcomes: The Framingham Heart Study</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>79</volume><issue>5</issue><spage>1045</spage><epage>1056</epage><pages>1045-1056</pages><issn>0194-911X</issn><issn>1524-4563</issn><eissn>1524-4563</eissn><abstract>Arterial stiffness increases with age and is associated with an increased risk of adverse outcomes on short-term follow-up (typically <10 years). Data regarding associations of arterial stiffness with health outcomes on longer-term follow-up are lacking.
We evaluated 7283 Framingham Study participants (mean age 50 years, 53% women) who underwent assessment of carotid-femoral pulse wave velocity (a marker of arterial stiffness) via applanation tonometry at one or more routine examinations. We used time-dependent Cox proportional hazards regression models to relate carotid-femoral pulse wave velocity to the incidence of health outcomes (updating carotid-femoral pulse wave velocity and all covariates at serial examinations).
On long-term follow-up (median 15 years; minimum-maximum, 0-20), participants developed cardiometabolic disease (hypertension [1255 events]; diabetes [381 events]), chronic kidney disease (529 events), dementia (235 events), cardiovascular disease (684 events) and its components (coronary heart disease [314 events], heart failure [191 events], transient ischemic attacks or stroke [250 events]), and death (1086 events). In multivariable-adjusted models, each SD increment in carotid-femoral pulse wave velocity was associated with increased risk of hypertension (hazard ratio [HR], 1.32 [95% CI, 1.21-1.44]), diabetes (HR, 1.32 [95% CI, 1.11-1.58]), chronic kidney disease (1.19 [95% CI, 1.05-1.34]), dementia (HR 1.27 [95% CI, 1.06-1.53]), cardiovascular disease (HR, 1.20 [95% CI, 1.06-1.36]) and its components (coronary heart disease, HR 1.37 [95% CI, 1.13-1.65]; transient ischemic attack/stroke, HR, 1.24 [95% CI, 1.00-1.53]), and death (HR, 1.29 [95% CI, 1.17-1.43]). The association with heart failure was borderline nonsignificant (HR, 1.21 [95% CI, 0.98-1.51],
=0.08).
Our prospective observations of a large community-based sample establish the long-term prognostic importance of arterial stiffness for multiple health outcomes.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>35168368</pmid><doi>10.1161/HYPERTENSIONAHA.121.18776</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-7357-5970</orcidid><orcidid>https://orcid.org/0000-0001-8551-7778</orcidid><orcidid>https://orcid.org/0000-0001-5643-3145</orcidid><orcidid>https://orcid.org/0000-0002-7352-621X</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0194-911X |
| ispartof | Hypertension (Dallas, Tex. 1979), 2022-05, Vol.79 (5), p.1045-1056 |
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| language | eng |
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| source | MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Dementia Diabetes Mellitus Female Heart Failure - epidemiology Humans Hypertension Longitudinal Studies Male Middle Aged Prospective Studies Pulse Wave Analysis Renal Insufficiency, Chronic Risk Factors Stroke Vascular Stiffness |
| title | Arterial Stiffness and Long-Term Risk of Health Outcomes: The Framingham Heart Study |
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