UTX condensation underlies its tumour-suppressive activity

UTX (also known as KDM6A ) encodes a histone H3K27 demethylase and is an important tumour suppressor that is frequently mutated in human cancers 1 . However, as the demethylase activity of UTX is often dispensable for mediating tumour suppression and developmental regulation 2 – 8 , the underlying m...

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Veröffentlicht in:	Nature (London) 2021-09, Vol.597 (7878), p.726-731
Hauptverfasser:	Shi, Bi, Li, Wei, Song, Yansu, Wang, Zhenjia, Ju, Rui, Ulman, Aleksandra, Hu, Jing, Palomba, Francesco, Zhao, Yanfang, Le, John Philip, Jarrard, William, Dimoff, David, Digman, Michelle A., Gratton, Enrico, Zang, Chongzhi, Jiang, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	38 38/35 38/39 631/337/176 631/45/612/100/2285 631/57/2269 631/67/1244 82 82/83 Amino acids Animals Cell Differentiation Chromatin Cloning Condensates Condensation Differentiation (biology) DNA methylation DNA-Binding Proteins - metabolism Embryonic Stem Cells - cytology Gene deletion Genes Genes, Tumor Suppressor Genomes HEK293 Cells Histone Demethylases - genetics Histone methyltransferase Histones Homology Humanities and Social Sciences Humans Intrinsically Disordered Proteins - genetics Leukemia Mice Molecular dynamics Morphology multidisciplinary Mutagenesis Mutation Neoplasm Proteins - metabolism Pancreatic cancer Phase separation Physiological aspects Protein Processing, Post-Translational Proteins Science Science (multidisciplinary) Stem cells THP-1 Cells Tumor suppressor genes Tumors
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