Synergistic Antimicrobial Metal Oxide-Doped Phosphate Glasses; a Potential Strategy to Reduce Antimicrobial Resistance and Host Cell Toxicity

The emergence of antimicrobial resistant strains bacteria and a decline in the discovery of new antibiotics has led to the idea of combining various antimicrobials to treat resistant strains and/or polymicrobial infections. Metal oxide-doped glasses have been extensively investigated for their antim...

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Veröffentlicht in:ACS biomaterials science & engineering 2022-03, Vol.8 (3), p.1193-1199
Hauptverfasser: Raja, Farah N. S, Worthington, Tony, de Souza, Lucas P. L, Hanaei, Shirin B, Martin, Richard A
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container_issue 3
container_start_page 1193
container_title ACS biomaterials science & engineering
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creator Raja, Farah N. S
Worthington, Tony
de Souza, Lucas P. L
Hanaei, Shirin B
Martin, Richard A
description The emergence of antimicrobial resistant strains bacteria and a decline in the discovery of new antibiotics has led to the idea of combining various antimicrobials to treat resistant strains and/or polymicrobial infections. Metal oxide-doped glasses have been extensively investigated for their antimicrobial potential; however to date, most experiments have focused on single metal species in isolation. The present study investigates the antimicrobial potential of sodium calcium phosphates (P2O5)50(Na2O)20(CaO)30–X (MO) X , where M is cobalt, copper, or zinc as single species. In addition, this work studied the effect of co-doping glasses containing two different metal ions (Co + Cu, Co + Zn, and Cu + Zn). The antimicrobial efficacy of all glasses was tested against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacterial strains, as well as a fungal strain (Candida albicans). Minimum inhibitory and bactericidal concentrations and time kill/synergy assays were used to assess the antimicrobial activity. An enhanced antimicrobial effect, at 5 mg/mL concentration, was exhibited by cobalt, copper, and zinc oxide glasses alone and in combinations. A synergistic antimicrobial effect was observed by Cu + Co and Cu + Zn against E. coli and Cu + Zn against S. aureus.
doi_str_mv 10.1021/acsbiomaterials.1c00876
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subjects Anti-Bacterial Agents - pharmacology
Anti-Infective Agents - pharmacology
Bacteria
Cobalt - pharmacology
Controlled Release and Delivery Systems
Copper - pharmacology
Drug Resistance, Bacterial
Escherichia coli
Phosphates - pharmacology
Staphylococcus aureus
Zinc Oxide
title Synergistic Antimicrobial Metal Oxide-Doped Phosphate Glasses; a Potential Strategy to Reduce Antimicrobial Resistance and Host Cell Toxicity
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