Monocytes transition to macrophages within the inflamed vasculature via monocyte CCR2 and endothelial TNFR2

Monocytes undergo phenotypic and functional changes in response to inflammatory cues, but the molecular signals that drive different monocyte states remain largely undefined. We show that monocytes acquire macrophage markers upon glomerulonephritis and may be derived from CCR2+CX3CR1+ double-positiv...

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Veröffentlicht in:	The Journal of experimental medicine 2022-05, Vol.219 (5)
Hauptverfasser:	Mysore, Vijayashree, Tahir, Suhail, Furuhashi, Kazuhiro, Arora, Jatin, Rosetti, Florencia, Cullere, Xavier, Yazbeck, Pascal, Sekulic, Miroslav, Lemieux, Madeleine E, Raychaudhuri, Soumya, Horwitz, Bruce H, Mayadas, Tanya N
Format:	Artikel
Sprache:	eng
Schlagworte:	Endothelial Cells Humans Innate Immunity and Inflammation Ligands Macrophages Monocytes Receptors, CCR2 - genetics Receptors, Tumor Necrosis Factor, Type II - genetics
Online-Zugang:	Volltext
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