Daily Exposure to a Cranberry Polyphenol Oral Rinse Alters the Oral Microbiome but Not Taste Perception in PROP Taster Status Classified Individuals
Diet and salivary proteins influence the composition of the oral microbiome, and recent data suggest that TAS2R38 bitter taste genetics may also play a role. We investigated the effects of daily exposure to a cranberry polyphenol oral rinse on taste perception, salivary proteins, and oral microbiota...
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| Veröffentlicht in: | Nutrients 2022-04, Vol.14 (7), p.1492 |
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| creator | Yousaf, Neeta Y Wu, Guojun Melis, Melania Mastinu, Mariano Contini, Cristina Cabras, Tiziana Tomassini Barbarossa, Iole Zhao, Liping Lam, Yan Y Tepper, Beverly J |
| description | Diet and salivary proteins influence the composition of the oral microbiome, and recent data suggest that TAS2R38 bitter taste genetics may also play a role. We investigated the effects of daily exposure to a cranberry polyphenol oral rinse on taste perception, salivary proteins, and oral microbiota. 6-n-Propylthiouracil (PROP) super-tasters (ST,
= 10) and non-tasters (NT,
= 10) rinsed with 30 mL of 0.75 g/L cranberry polyphenol extract (CPE) in spring water, twice daily for 11 days while consuming their habitual diets. The 16S rRNA gene sequencing showed that the NT oral microbiome composition was different than that of STs at baseline (
= 0.012) but not after the intervention (
= 0.525). Principal coordinates analysis using unweighted UniFrac distance showed that CPE modified microbiome composition in NTs (
= 0.023) but not in STs (
= 0.096). The intervention also altered specific salivary protein levels (α-amylase, MUC-5B, and selected S-type Cystatins) with no changes in sensory perception. Correlation networks between oral microbiota, salivary proteins, and sensory ratings showed that the ST microbiome had a more complex relationship with salivary proteins, particularly proline-rich proteins, than that in NTs. These findings show that CPE modulated the oral microbiome of NTs to be similar to that of STs, which could have implications for oral health. |
| doi_str_mv | 10.3390/nu14071492 |
| format | Article |
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= 10) and non-tasters (NT,
= 10) rinsed with 30 mL of 0.75 g/L cranberry polyphenol extract (CPE) in spring water, twice daily for 11 days while consuming their habitual diets. The 16S rRNA gene sequencing showed that the NT oral microbiome composition was different than that of STs at baseline (
= 0.012) but not after the intervention (
= 0.525). Principal coordinates analysis using unweighted UniFrac distance showed that CPE modified microbiome composition in NTs (
= 0.023) but not in STs (
= 0.096). The intervention also altered specific salivary protein levels (α-amylase, MUC-5B, and selected S-type Cystatins) with no changes in sensory perception. Correlation networks between oral microbiota, salivary proteins, and sensory ratings showed that the ST microbiome had a more complex relationship with salivary proteins, particularly proline-rich proteins, than that in NTs. These findings show that CPE modulated the oral microbiome of NTs to be similar to that of STs, which could have implications for oral health.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu14071492</identifier><identifier>PMID: 35406108</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Bitter taste ; Composition ; Dental caries ; Disease ; Food ; Genetic engineering ; Genetics ; Genotype & phenotype ; Humans ; Microbiomes ; Microbiota ; Mouthwashes - pharmacology ; Oral hygiene ; Perception ; Plant extracts ; Plant Extracts - pharmacology ; Polyphenols ; Polyphenols - pharmacology ; Propylthiouracil ; Propylthiouracil - pharmacology ; Proteins ; Ratings & rankings ; RNA, Ribosomal, 16S - genetics ; rRNA 16S ; Salivary Proteins and Peptides ; Sensory perception ; Spring water ; Taste ; Taste perception ; Taste Perception - genetics ; Taste receptors ; Vaccinium macrocarpon ; α-Amylase</subject><ispartof>Nutrients, 2022-04, Vol.14 (7), p.1492</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-97bb805448caa2ab7bdbe2ca7138867c89136ea38cd4c56f37bde031ec2007233</citedby><cites>FETCH-LOGICAL-c406t-97bb805448caa2ab7bdbe2ca7138867c89136ea38cd4c56f37bde031ec2007233</cites><orcidid>0000-0003-3410-3158 ; 0000-0002-5724-1142 ; 0000-0003-3833-9707 ; 0000-0002-5033-6632 ; 0000-0002-2849-4052 ; 0000-0002-0903-4675 ; 0000-0002-7910-2813</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002539/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002539/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35406108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yousaf, Neeta Y</creatorcontrib><creatorcontrib>Wu, Guojun</creatorcontrib><creatorcontrib>Melis, Melania</creatorcontrib><creatorcontrib>Mastinu, Mariano</creatorcontrib><creatorcontrib>Contini, Cristina</creatorcontrib><creatorcontrib>Cabras, Tiziana</creatorcontrib><creatorcontrib>Tomassini Barbarossa, Iole</creatorcontrib><creatorcontrib>Zhao, Liping</creatorcontrib><creatorcontrib>Lam, Yan Y</creatorcontrib><creatorcontrib>Tepper, Beverly J</creatorcontrib><title>Daily Exposure to a Cranberry Polyphenol Oral Rinse Alters the Oral Microbiome but Not Taste Perception in PROP Taster Status Classified Individuals</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Diet and salivary proteins influence the composition of the oral microbiome, and recent data suggest that TAS2R38 bitter taste genetics may also play a role. We investigated the effects of daily exposure to a cranberry polyphenol oral rinse on taste perception, salivary proteins, and oral microbiota. 6-n-Propylthiouracil (PROP) super-tasters (ST,
= 10) and non-tasters (NT,
= 10) rinsed with 30 mL of 0.75 g/L cranberry polyphenol extract (CPE) in spring water, twice daily for 11 days while consuming their habitual diets. The 16S rRNA gene sequencing showed that the NT oral microbiome composition was different than that of STs at baseline (
= 0.012) but not after the intervention (
= 0.525). Principal coordinates analysis using unweighted UniFrac distance showed that CPE modified microbiome composition in NTs (
= 0.023) but not in STs (
= 0.096). The intervention also altered specific salivary protein levels (α-amylase, MUC-5B, and selected S-type Cystatins) with no changes in sensory perception. Correlation networks between oral microbiota, salivary proteins, and sensory ratings showed that the ST microbiome had a more complex relationship with salivary proteins, particularly proline-rich proteins, than that in NTs. These findings show that CPE modulated the oral microbiome of NTs to be similar to that of STs, which could have implications for oral health.</description><subject>Bitter taste</subject><subject>Composition</subject><subject>Dental caries</subject><subject>Disease</subject><subject>Food</subject><subject>Genetic engineering</subject><subject>Genetics</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Mouthwashes - pharmacology</subject><subject>Oral hygiene</subject><subject>Perception</subject><subject>Plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Polyphenols</subject><subject>Polyphenols - pharmacology</subject><subject>Propylthiouracil</subject><subject>Propylthiouracil - pharmacology</subject><subject>Proteins</subject><subject>Ratings & rankings</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>rRNA 16S</subject><subject>Salivary Proteins and Peptides</subject><subject>Sensory perception</subject><subject>Spring water</subject><subject>Taste</subject><subject>Taste perception</subject><subject>Taste Perception - genetics</subject><subject>Taste receptors</subject><subject>Vaccinium macrocarpon</subject><subject>α-Amylase</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkcFuEzEQhi0EolXohQdAI3FBSAGvvbvevSBVoUClQqJSzpbtnRBXjr21vRV5Dx4Yh5RS8GWsmU-__pmfkOcVfcN5T9_6qaqpqOqePSLHjAo2b9uaP37wPyInKV3T_RNUtPwpOeJNTduKdsfk53tl3Q7OfowhTREhB1CwiMprjHEHq-B24wZ9cLCMysGl9Qnh1GWMCfIGD93P1sSgbdgi6CnDl5DhSqWMsMJocMw2eLAeVpfL1WEQ4WtWeUqwcColu7Y4wLkf7K0dJuXSM_JkXQqe3NUZ-fbh7GrxaX6x_Hi-OL2Ym2I_z3uhdUebuu6MUkxpoQeNzChR8a5rhen6ireoeGeG2jTtmhcAKa_QsHIKxvmMvDvojpPe4mDQ57KOHKPdqriTQVn578TbjfwebmVPKWt4XwRe3QnEcDNhynJrk0HnlMcwJcnaum96JpqmoC__Q6_DFH1Z7ze1FyyWZuT1gSoHTSni-t5MReU-b_k37wK_eGj_Hv2TLv8Fq_enUQ</recordid><startdate>20220402</startdate><enddate>20220402</enddate><creator>Yousaf, Neeta Y</creator><creator>Wu, Guojun</creator><creator>Melis, Melania</creator><creator>Mastinu, Mariano</creator><creator>Contini, Cristina</creator><creator>Cabras, Tiziana</creator><creator>Tomassini Barbarossa, Iole</creator><creator>Zhao, Liping</creator><creator>Lam, Yan Y</creator><creator>Tepper, Beverly J</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3410-3158</orcidid><orcidid>https://orcid.org/0000-0002-5724-1142</orcidid><orcidid>https://orcid.org/0000-0003-3833-9707</orcidid><orcidid>https://orcid.org/0000-0002-5033-6632</orcidid><orcidid>https://orcid.org/0000-0002-2849-4052</orcidid><orcidid>https://orcid.org/0000-0002-0903-4675</orcidid><orcidid>https://orcid.org/0000-0002-7910-2813</orcidid></search><sort><creationdate>20220402</creationdate><title>Daily Exposure to a Cranberry Polyphenol Oral Rinse Alters the Oral Microbiome but Not Taste Perception in PROP Taster Status Classified Individuals</title><author>Yousaf, Neeta Y ; 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We investigated the effects of daily exposure to a cranberry polyphenol oral rinse on taste perception, salivary proteins, and oral microbiota. 6-n-Propylthiouracil (PROP) super-tasters (ST,
= 10) and non-tasters (NT,
= 10) rinsed with 30 mL of 0.75 g/L cranberry polyphenol extract (CPE) in spring water, twice daily for 11 days while consuming their habitual diets. The 16S rRNA gene sequencing showed that the NT oral microbiome composition was different than that of STs at baseline (
= 0.012) but not after the intervention (
= 0.525). Principal coordinates analysis using unweighted UniFrac distance showed that CPE modified microbiome composition in NTs (
= 0.023) but not in STs (
= 0.096). The intervention also altered specific salivary protein levels (α-amylase, MUC-5B, and selected S-type Cystatins) with no changes in sensory perception. Correlation networks between oral microbiota, salivary proteins, and sensory ratings showed that the ST microbiome had a more complex relationship with salivary proteins, particularly proline-rich proteins, than that in NTs. These findings show that CPE modulated the oral microbiome of NTs to be similar to that of STs, which could have implications for oral health.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35406108</pmid><doi>10.3390/nu14071492</doi><orcidid>https://orcid.org/0000-0003-3410-3158</orcidid><orcidid>https://orcid.org/0000-0002-5724-1142</orcidid><orcidid>https://orcid.org/0000-0003-3833-9707</orcidid><orcidid>https://orcid.org/0000-0002-5033-6632</orcidid><orcidid>https://orcid.org/0000-0002-2849-4052</orcidid><orcidid>https://orcid.org/0000-0002-0903-4675</orcidid><orcidid>https://orcid.org/0000-0002-7910-2813</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrients, 2022-04, Vol.14 (7), p.1492 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Bitter taste Composition Dental caries Disease Food Genetic engineering Genetics Genotype & phenotype Humans Microbiomes Microbiota Mouthwashes - pharmacology Oral hygiene Perception Plant extracts Plant Extracts - pharmacology Polyphenols Polyphenols - pharmacology Propylthiouracil Propylthiouracil - pharmacology Proteins Ratings & rankings RNA, Ribosomal, 16S - genetics rRNA 16S Salivary Proteins and Peptides Sensory perception Spring water Taste Taste perception Taste Perception - genetics Taste receptors Vaccinium macrocarpon α-Amylase |
| title | Daily Exposure to a Cranberry Polyphenol Oral Rinse Alters the Oral Microbiome but Not Taste Perception in PROP Taster Status Classified Individuals |
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