A Review of the Recent Developments of Molecular Hybrids Targeting Tubulin Polymerization

Microtubules are cylindrical protein polymers formed from -tubulin heterodimers in the cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the G2/M phase, and anomalous mitotic spindles will form. Microtubules are an important target for cancer drug action because o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of molecular sciences 2022-04, Vol.23 (7), p.4001
Hauptverfasser:	Ebenezer, Oluwakemi, Shapi, Michael, Tuszynski, Jack A
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Biological activity Cancer therapies Cell cycle Cell division Cell growth Chemical compounds Chemotherapy Cytoplasm Drug development Drug resistance Humans Hybridization Hybrids Inhibitors Literature reviews Lung cancer Microtubules Microtubules - metabolism Mitosis Molecular structure Mortality Multidrug resistance Neoplasms - drug therapy Neoplasms - metabolism Pharmaceutical sciences Pharmacokinetics Pharmacology Pharmacophores Polymerization Review Scaffolds Signal transduction Spindles Tubulin Tubulin - metabolism Tubulin Modulators - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!