Surgery for Liver Metastasis of Non-Colorectal and Non-Neuroendocrine Tumors
Surgery has become well established for patients with colorectal and neuroendocrine liver metastases. However, the value of this procedure in non-colorectal and non-neuroendocrine metastases (NCRNNELMs) remains unclear. We analyzed the outcomes of patients that underwent liver surgery for NCRNNELMs...
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| Veröffentlicht in: | Journal of clinical medicine 2022-03, Vol.11 (7), p.1906 |
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| creator | Katou, Shadi Schmid, Franziska Silveira, Carolina Schäfer, Lina Naim, Tizian Becker, Felix Radunz, Sonia Juratli, Mazen A Seifert, Leon Louis Heinzow, Hauke Struecker, Benjamin Pascher, Andreas Morgul, M Haluk |
| description | Surgery has become well established for patients with colorectal and neuroendocrine liver metastases. However, the value of this procedure in non-colorectal and non-neuroendocrine metastases (NCRNNELMs) remains unclear. We analyzed the outcomes of patients that underwent liver surgery for NCRNNELMs and for colorectal liver metastases (CRLMs) between 2012 and 2017 at our institution. Prognostic factors of overall and recurrence-free survival were analyzed, and a comparison of survival between two groups was performed. Seventy-three patients (30 NCRNNELM and 43 CRLM) were included in this study. Although the mean age, extrahepatic metastases, and rate of reoperation were significantly different between the groups, recurrence-free survival was comparable. The 5-year overall survival rates were 38% for NCRNNELM and 55% for CRLM. In univariate analysis, a patient age of ≥60 years, endodermal origin of the primary tumor, and major complications were negative prognostic factors. Resection for NCRNNELM showed comparable results to resection for CRLM. Age, the embryological origin of the primary tumor, and the number of metastases might be the criteria for patient selection. |
| doi_str_mv | 10.3390/jcm11071906 |
| format | Article |
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However, the value of this procedure in non-colorectal and non-neuroendocrine metastases (NCRNNELMs) remains unclear. We analyzed the outcomes of patients that underwent liver surgery for NCRNNELMs and for colorectal liver metastases (CRLMs) between 2012 and 2017 at our institution. Prognostic factors of overall and recurrence-free survival were analyzed, and a comparison of survival between two groups was performed. Seventy-three patients (30 NCRNNELM and 43 CRLM) were included in this study. Although the mean age, extrahepatic metastases, and rate of reoperation were significantly different between the groups, recurrence-free survival was comparable. The 5-year overall survival rates were 38% for NCRNNELM and 55% for CRLM. In univariate analysis, a patient age of ≥60 years, endodermal origin of the primary tumor, and major complications were negative prognostic factors. Resection for NCRNNELM showed comparable results to resection for CRLM. Age, the embryological origin of the primary tumor, and the number of metastases might be the criteria for patient selection.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm11071906</identifier><identifier>PMID: 35407514</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Breast cancer ; Cancer therapies ; Clinical medicine ; Disease ; Esophagus ; Hepatectomy ; Interdisciplinary aspects ; Liver ; Medical prognosis ; Metastasis ; Neuroendocrine tumors ; Patients ; Surgery ; Surgical outcomes ; Surgical techniques</subject><ispartof>Journal of clinical medicine, 2022-03, Vol.11 (7), p.1906</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-ea299f5382333a780eca462829484c93cd4cb4d7a95f3df92c7eed232d0eb3923</citedby><cites>FETCH-LOGICAL-c405t-ea299f5382333a780eca462829484c93cd4cb4d7a95f3df92c7eed232d0eb3923</cites><orcidid>0000-0002-0089-7669 ; 0000-0001-8789-0277 ; 0000-0002-1793-0672 ; 0000-0002-3874-1336 ; 0000-0002-7435-2098 ; 0000-0001-5482-7458</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999547/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999547/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35407514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katou, Shadi</creatorcontrib><creatorcontrib>Schmid, Franziska</creatorcontrib><creatorcontrib>Silveira, Carolina</creatorcontrib><creatorcontrib>Schäfer, Lina</creatorcontrib><creatorcontrib>Naim, Tizian</creatorcontrib><creatorcontrib>Becker, Felix</creatorcontrib><creatorcontrib>Radunz, Sonia</creatorcontrib><creatorcontrib>Juratli, Mazen A</creatorcontrib><creatorcontrib>Seifert, Leon Louis</creatorcontrib><creatorcontrib>Heinzow, Hauke</creatorcontrib><creatorcontrib>Struecker, Benjamin</creatorcontrib><creatorcontrib>Pascher, Andreas</creatorcontrib><creatorcontrib>Morgul, M Haluk</creatorcontrib><title>Surgery for Liver Metastasis of Non-Colorectal and Non-Neuroendocrine Tumors</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Surgery has become well established for patients with colorectal and neuroendocrine liver metastases. However, the value of this procedure in non-colorectal and non-neuroendocrine metastases (NCRNNELMs) remains unclear. We analyzed the outcomes of patients that underwent liver surgery for NCRNNELMs and for colorectal liver metastases (CRLMs) between 2012 and 2017 at our institution. Prognostic factors of overall and recurrence-free survival were analyzed, and a comparison of survival between two groups was performed. Seventy-three patients (30 NCRNNELM and 43 CRLM) were included in this study. Although the mean age, extrahepatic metastases, and rate of reoperation were significantly different between the groups, recurrence-free survival was comparable. The 5-year overall survival rates were 38% for NCRNNELM and 55% for CRLM. In univariate analysis, a patient age of ≥60 years, endodermal origin of the primary tumor, and major complications were negative prognostic factors. Resection for NCRNNELM showed comparable results to resection for CRLM. Age, the embryological origin of the primary tumor, and the number of metastases might be the criteria for patient selection.</description><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Clinical medicine</subject><subject>Disease</subject><subject>Esophagus</subject><subject>Hepatectomy</subject><subject>Interdisciplinary aspects</subject><subject>Liver</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Neuroendocrine tumors</subject><subject>Patients</subject><subject>Surgery</subject><subject>Surgical outcomes</subject><subject>Surgical techniques</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkU1LxDAQhoMorqgn71LwIkg1zSSb5CLI4hdUPajnkE2na5e20aRd2H9v1XVZHQZmmHl4meEl5Cij5wCaXsxdk2VUZpqOt8geo1KmFBRsb_QjchjjnA6hFGeZ3CUjEJxKkfE9kj_3YYZhmZQ-JHm1wJA8YGfjkFVMfJk8-jad-NoHdJ2tE9sW36NH7IPHtvAuVC0mL33jQzwgO6WtIx6u6j55vbl-mdyl-dPt_eQqTx2nokvRMq1LAYoBgJWKorN8zBTTXHGnwRXcTXkhrRYlFKVmTiIWDFhBcQqawT65_NF976cNFg7bLtjavIeqsWFpvK3M301bvZmZXxiltRZcDgKnK4HgP3qMnWmq6LCubYu-j4aNuRaaCq4H9OQfOvd9aIf3vinKKAgYqLMfygUfY8ByfUxGzZdRZsOogT7evH_N_toCn3EIjjM</recordid><startdate>20220329</startdate><enddate>20220329</enddate><creator>Katou, Shadi</creator><creator>Schmid, Franziska</creator><creator>Silveira, Carolina</creator><creator>Schäfer, Lina</creator><creator>Naim, Tizian</creator><creator>Becker, Felix</creator><creator>Radunz, Sonia</creator><creator>Juratli, Mazen A</creator><creator>Seifert, Leon Louis</creator><creator>Heinzow, Hauke</creator><creator>Struecker, Benjamin</creator><creator>Pascher, Andreas</creator><creator>Morgul, M Haluk</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0089-7669</orcidid><orcidid>https://orcid.org/0000-0001-8789-0277</orcidid><orcidid>https://orcid.org/0000-0002-1793-0672</orcidid><orcidid>https://orcid.org/0000-0002-3874-1336</orcidid><orcidid>https://orcid.org/0000-0002-7435-2098</orcidid><orcidid>https://orcid.org/0000-0001-5482-7458</orcidid></search><sort><creationdate>20220329</creationdate><title>Surgery for Liver Metastasis of Non-Colorectal and Non-Neuroendocrine Tumors</title><author>Katou, Shadi ; 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| subjects | Breast cancer Cancer therapies Clinical medicine Disease Esophagus Hepatectomy Interdisciplinary aspects Liver Medical prognosis Metastasis Neuroendocrine tumors Patients Surgery Surgical outcomes Surgical techniques |
| title | Surgery for Liver Metastasis of Non-Colorectal and Non-Neuroendocrine Tumors |
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