The Relevance in the Neutrophil to Lymphocyte Ratio and the SARC-F Score in Gastrointestinal Diseases
We sought to clarify the relevance in the neutrophil to lymphocyte ratio (NLR) and the SARC-F score in patients with gastrointestinal diseases (G-Ds, n = 672, median age = 73 years). Univariate and multivariate analysis for the SARC-F score were performed. Advanced malignancy was identified in 162 p...
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| Veröffentlicht in: | Journal of clinical medicine 2022-04, Vol.11 (7), p.2012 |
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| creator | Yamasaki, Eiki Nishikawa, Hiroki Goto, Masahiro Matsui, Masahiro Asai, Akira Ushiro, Kosuke Ogura, Takeshi Takeuchi, Toshihisa Nakamura, Shiro Kakimoto, Kazuki Miyazaki, Takako Fukunishi, Shinya Ohama, Hideko Yokohama, Keisuke Yasuoka, Hidetaka Higuchi, Kazuhide |
| description | We sought to clarify the relevance in the neutrophil to lymphocyte ratio (NLR) and the SARC-F score in patients with gastrointestinal diseases (G-Ds, n = 672, median age = 73 years). Univariate and multivariate analysis for the SARC-F score were performed. Advanced malignancy was identified in 162 patients (24.1%). The median of NLR for all cases was 2.65. The median of NLR in ECOG-PS 0 (n = 436), 1 (n = 128), 2 (n = 49) and 3 or 4 (n = 59) was 2.26, 2.97, 4.41 and 5.99 (overall p < 0.0001). NLR had a significant correlation with the SARC-F score (r = 0.54, p < 0.0001). The median of NLR in the SARC-F score ≥4 (recommended value for sarcopenia, n = 84) and |
| doi_str_mv | 10.3390/jcm11072012 |
| format | Article |
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Univariate and multivariate analysis for the SARC-F score were performed. Advanced malignancy was identified in 162 patients (24.1%). The median of NLR for all cases was 2.65. The median of NLR in ECOG-PS 0 (n = 436), 1 (n = 128), 2 (n = 49) and 3 or 4 (n = 59) was 2.26, 2.97, 4.41 and 5.99 (overall p < 0.0001). NLR had a significant correlation with the SARC-F score (r = 0.54, p < 0.0001). The median of NLR in the SARC-F score ≥4 (recommended value for sarcopenia, n = 84) and <4 (n = 588) was 5.87 and 2.48 (p < 0.0001). In all subgroup analyses, similar trends were seen. In the multivariate analysis, ECOG-PS (p < 0.0001) and NLR (p < 0.0001) were independent factors, while age had a trend for significance (p = 0.0686). In conclusion, we would like to emphasize the usefulness of NLR, a simple marker assessed only by blood tests, in predicting the possibility for sarcopenia by the SARC-F in G-Ds.]]></description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm11072012</identifier><identifier>PMID: 35407620</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Body mass index ; Cancer ; Clinical medicine ; Females ; Gastrointestinal diseases ; Inflammation ; Lymphocytes ; Malnutrition ; Multivariate analysis ; Neutrophils ; Patients ; Questionnaires ; Sarcopenia</subject><ispartof>Journal of clinical medicine, 2022-04, Vol.11 (7), p.2012</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-423538b04f12b6a607fddf4632b2878250e5966026cbeb30f6cb20e80764db5b3</citedby><cites>FETCH-LOGICAL-c405t-423538b04f12b6a607fddf4632b2878250e5966026cbeb30f6cb20e80764db5b3</cites><orcidid>0000-0002-2915-7875 ; 0000-0002-1882-824X ; 0000-0002-5211-4021</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999347/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999347/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35407620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamasaki, Eiki</creatorcontrib><creatorcontrib>Nishikawa, Hiroki</creatorcontrib><creatorcontrib>Goto, Masahiro</creatorcontrib><creatorcontrib>Matsui, Masahiro</creatorcontrib><creatorcontrib>Asai, Akira</creatorcontrib><creatorcontrib>Ushiro, Kosuke</creatorcontrib><creatorcontrib>Ogura, Takeshi</creatorcontrib><creatorcontrib>Takeuchi, Toshihisa</creatorcontrib><creatorcontrib>Nakamura, Shiro</creatorcontrib><creatorcontrib>Kakimoto, Kazuki</creatorcontrib><creatorcontrib>Miyazaki, Takako</creatorcontrib><creatorcontrib>Fukunishi, Shinya</creatorcontrib><creatorcontrib>Ohama, Hideko</creatorcontrib><creatorcontrib>Yokohama, Keisuke</creatorcontrib><creatorcontrib>Yasuoka, Hidetaka</creatorcontrib><creatorcontrib>Higuchi, Kazuhide</creatorcontrib><title>The Relevance in the Neutrophil to Lymphocyte Ratio and the SARC-F Score in Gastrointestinal Diseases</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description><![CDATA[We sought to clarify the relevance in the neutrophil to lymphocyte ratio (NLR) and the SARC-F score in patients with gastrointestinal diseases (G-Ds, n = 672, median age = 73 years). Univariate and multivariate analysis for the SARC-F score were performed. Advanced malignancy was identified in 162 patients (24.1%). The median of NLR for all cases was 2.65. The median of NLR in ECOG-PS 0 (n = 436), 1 (n = 128), 2 (n = 49) and 3 or 4 (n = 59) was 2.26, 2.97, 4.41 and 5.99 (overall p < 0.0001). NLR had a significant correlation with the SARC-F score (r = 0.54, p < 0.0001). The median of NLR in the SARC-F score ≥4 (recommended value for sarcopenia, n = 84) and <4 (n = 588) was 5.87 and 2.48 (p < 0.0001). In all subgroup analyses, similar trends were seen. In the multivariate analysis, ECOG-PS (p < 0.0001) and NLR (p < 0.0001) were independent factors, while age had a trend for significance (p = 0.0686). 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Univariate and multivariate analysis for the SARC-F score were performed. Advanced malignancy was identified in 162 patients (24.1%). The median of NLR for all cases was 2.65. The median of NLR in ECOG-PS 0 (n = 436), 1 (n = 128), 2 (n = 49) and 3 or 4 (n = 59) was 2.26, 2.97, 4.41 and 5.99 (overall p < 0.0001). NLR had a significant correlation with the SARC-F score (r = 0.54, p < 0.0001). The median of NLR in the SARC-F score ≥4 (recommended value for sarcopenia, n = 84) and <4 (n = 588) was 5.87 and 2.48 (p < 0.0001). In all subgroup analyses, similar trends were seen. In the multivariate analysis, ECOG-PS (p < 0.0001) and NLR (p < 0.0001) were independent factors, while age had a trend for significance (p = 0.0686). 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| subjects | Body mass index Cancer Clinical medicine Females Gastrointestinal diseases Inflammation Lymphocytes Malnutrition Multivariate analysis Neutrophils Patients Questionnaires Sarcopenia |
| title | The Relevance in the Neutrophil to Lymphocyte Ratio and the SARC-F Score in Gastrointestinal Diseases |
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