In Vivo and In Vitro Cartilage Differentiation from Embryonic Epicardial Progenitor Cells
The presence of cartilage tissue in the embryonic and adult hearts of different vertebrate species is a well-recorded fact. However, while the embryonic neural crest has been historically considered as the main source of cardiac cartilage, recently reported results on the wide connective potential o...
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| Veröffentlicht in: | International journal of molecular sciences 2022-03, Vol.23 (7), p.3614 |
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| creator | Palmquist-Gomes, Paul Marín-Sedeño, Ernesto Ruiz-Villalba, Adrián Rico-Llanos, Gustavo Adolfo Pérez-Pomares, José María Guadix, Juan Antonio |
| description | The presence of cartilage tissue in the embryonic and adult hearts of different vertebrate species is a well-recorded fact. However, while the embryonic neural crest has been historically considered as the main source of cardiac cartilage, recently reported results on the wide connective potential of epicardial lineage cells suggest they could also differentiate into chondrocytes. In this work, we describe the formation of cardiac cartilage clusters from proepicardial cells, both in vivo and in vitro. Our findings report, for the first time, cartilage formation from epicardial progenitor cells, and strongly support the concept of proepicardial cells as multipotent connective progenitors. These results are relevant to our understanding of cardiac cell complexity and the responses of cardiac connective tissues to pathologic stimuli. |
| doi_str_mv | 10.3390/ijms23073614 |
| format | Article |
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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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However, while the embryonic neural crest has been historically considered as the main source of cardiac cartilage, recently reported results on the wide connective potential of epicardial lineage cells suggest they could also differentiate into chondrocytes. In this work, we describe the formation of cardiac cartilage clusters from proepicardial cells, both in vivo and in vitro. Our findings report, for the first time, cartilage formation from epicardial progenitor cells, and strongly support the concept of proepicardial cells as multipotent connective progenitors. These results are relevant to our understanding of cardiac cell complexity and the responses of cardiac connective tissues to pathologic stimuli.</description><subject>Cartilage</subject><subject>Cell differentiation</subject><subject>Cell Differentiation - physiology</subject><subject>Chondrocytes</subject><subject>Connective tissue</subject><subject>Coronary vessels</subject><subject>Embryonic Stem Cells</subject><subject>Embryos</subject><subject>Fibroblasts</subject><subject>Heart</subject><subject>Neural Crest</subject><subject>Neural stem cells</subject><subject>Pericardium</subject><subject>Progenitor cells</subject><subject>Smooth muscle</subject><subject>Vertebrates</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkc1LAzEQxYMotlZvniXgxYPVbJLdbC6C1KqFgh5U8BTSbFJTdpOa7Bb637v9sFRhYIaZH495PADOE3RDCEe3dlZFTBAjWUIPQDehGPcRytjh3twBJzHOEMIEp_wYdEhKUc4Z7YLPkYMfduGhdAVcz3XwcCBDbUs51fDBGqODdrWVtfUOmuArOKwmYemdVXA4t0qGwsoSvgY_1c7WPsCBLst4Co6MLKM-2_YeeH8cvg2e--OXp9HgftxXNMF1X2ljUE4VkUxnGWJUU5WnhqZUsUIWMtGJQaZd4yLjWmOWYckkJ4YylJMUkx642-jOm0mlC9X-GmQp5sFWMiyFl1b8vTj7JaZ-IXLOeYJJK3C1FQj-u9GxFpWNqrUgnfZNFDijPM1z0lYPXP5DZ74JrrW3plDKKFlR1xtKBR9j0Gb3TILEKjOxn1mLX-wb2MG_IZEf46yTPQ</recordid><startdate>20220325</startdate><enddate>20220325</enddate><creator>Palmquist-Gomes, Paul</creator><creator>Marín-Sedeño, Ernesto</creator><creator>Ruiz-Villalba, Adrián</creator><creator>Rico-Llanos, Gustavo Adolfo</creator><creator>Pérez-Pomares, José María</creator><creator>Guadix, Juan Antonio</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4291-6645</orcidid><orcidid>https://orcid.org/0000-0001-7819-6507</orcidid></search><sort><creationdate>20220325</creationdate><title>In Vivo and In Vitro Cartilage Differentiation from Embryonic Epicardial Progenitor Cells</title><author>Palmquist-Gomes, Paul ; 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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Cartilage Cell differentiation Cell Differentiation - physiology Chondrocytes Connective tissue Coronary vessels Embryonic Stem Cells Embryos Fibroblasts Heart Neural Crest Neural stem cells Pericardium Progenitor cells Smooth muscle Vertebrates |
| title | In Vivo and In Vitro Cartilage Differentiation from Embryonic Epicardial Progenitor Cells |
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