Folic Acid Treatment Directly Influences the Genetic and Epigenetic Regulation along with the Associated Cellular Maintenance Processes of HT-29 and SW480 Colorectal Cancer Cell Lines

Folic acid (FA) is a synthetic form of vitamin B9, generally used as a nutritional supplement and an adjunctive medication in cancer therapy. FA is involved in genetic and epigenetic regulation; therefore, it has a dual modulatory role in established neoplasms. We aimed to investigate the effect of...

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Veröffentlicht in:	Cancers 2022-04, Vol.14 (7), p.1820
Hauptverfasser:	Zsigrai, Sára, Kalmár, Alexandra, Barták, Barbara K, Nagy, Zsófia B, Szigeti, Krisztina A, Valcz, Gábor, Kothalawala, William, Dankó, Titanilla, Sebestyén, Anna, Barna, Gábor, Pipek, Orsolya, Csabai, István, Tulassay, Zsolt, Igaz, Péter, Takács, István, Molnár, Béla
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Bioavailability Cancer Carcinogenesis Cell cycle Cell division Cell growth Cell proliferation Cell viability Chromosomes Colorectal cancer Colorectal carcinoma Comet assay DNA biosynthesis DNA methylation DNA microarrays DNA repair Epigenetics Folic acid Gene expression Monocyte chemoattractant protein 1 Mutation Stat3 protein Tumor cell lines Tumors Vitamin B Vitamin deficiency
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