Expression of CD47 and SIRPα Macrophage Immune-Checkpoint Pathway in Non-Small-Cell Lung Cancer

Cancer cells escape macrophage phagocytosis by expressing the CD47 integrin-associated protein that binds to the SIRPα ligand (signal regulatory protein alpha) expressed by macrophages. Immunotherapy targeting this pathway is under clinical development. We investigated the expression of CD47/SIRPα m...

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Veröffentlicht in:	Cancers 2022-04, Vol.14 (7), p.1801
Hauptverfasser:	Giatromanolaki, Alexandra, Mitrakas, Achilleas, Anestopoulos, Ioannis, Kontosis, Andreas, Koukourakis, Ioannis M, Pappa, Aglaia, Panayiotidis, Mihalis I, Koukourakis, Michael I
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Esophagus Foxp3 protein Histology Immune checkpoint Immunotherapy Investigations Ligands Lung cancer Lymphocytes Macrophages Medical prognosis Metastases Non-small cell lung carcinoma PD-1 protein PD-L1 protein Phagocytosis Prognosis Regression analysis Signal regulatory protein-α Small cell lung carcinoma Stroma Survival analysis Tumor-infiltrating lymphocytes Tumors
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