Ricolinostat enhances adavosertib‑induced mitotic catastrophe in TP53‑mutated head and neck squamous cell carcinoma cells

mutation is one of the most frequent gene mutations in head and neck squamous cell carcinoma (HNSCC) and could be a potential therapeutic target. Recently, the WEE1 G2 checkpoint kinase (WEE1) inhibitor adavosertib (Adv) has attracted attention because of its selective cytotoxicity against ‑mutated...

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Veröffentlicht in:	International journal of oncology 2022-05, Vol.60 (5), p.1, Article 54
Hauptverfasser:	Miyake, Keitaro, Takano, Naoharu, Kazama, Hiromi, Kikuchi, Hiroyuki, Hiramoto, Masaki, Tsukahara, Kiyoaki, Miyazawa, Keisuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cancer therapies Catastrophes Cell cycle Cell death Cell Line, Tumor Cyclin-dependent kinases Cytotoxicity DNA damage Gene mutations Genetic aspects Head & neck cancer Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - genetics Health aspects Human papillomavirus Humans Hydroxamic Acids Kinases Lung cancer Medical research Medicine, Experimental Mutation Papillomavirus infections Plasmids Pyrazoles Pyrimidines Pyrimidinones Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - drug therapy Squamous Cell Carcinoma of Head and Neck - genetics Tumor proteins Tumor Suppressor Protein p53 - genetics
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