Amlodipine-Induced Subacute Cutaneous Lupus Erythematosus Localized to Non-Sun-Exposed Areas
The cutaneous manifestations of subacute cutaneous lupus erythematosus (SCLE), a subset of cutaneous lupus erythematosus, arise most often in sun-exposed areas. We report a case of SCLE with atypical distribution, following treatment with amlodipine. This highlighted a possible clue that can be used...
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| Veröffentlicht in: | Case Reports in Dermatology 2022-03, Vol.14 (1), p.71-76 |
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| creator | Mizuta, Takahiro Kato, Miyuki |
| description | The cutaneous manifestations of subacute cutaneous lupus erythematosus (SCLE), a subset of cutaneous lupus erythematosus, arise most often in sun-exposed areas. We report a case of SCLE with atypical distribution, following treatment with amlodipine. This highlighted a possible clue that can be used to clinically distinguish a drug-induced case from an idiopathic disorder. A 92-year-old Japanese woman presented with a 2-month history of progressive erythematous, papulosquamous rash, and annular plaques in non-sun-exposed sites with no systemic symptoms. Irbesartan/amlodipine besilate combination tablets were prescribed 8 months earlier for hypertension. The appearance of the skin eruptions, results of immunopathological findings, and temporal relationship between the rash and drugs were suggestive of a diagnosis of drug-induced SCLE, which was confirmed by the spontaneous resolution of these cutaneous eruptions within 4 weeks after cessation of amlodipine treatment. The evaluation of possible associations with medications should be performed in patients presenting with clinical features characterizing SCLE in atypical sites (non-sun-exposed areas). |
| doi_str_mv | 10.1159/000524001 |
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We report a case of SCLE with atypical distribution, following treatment with amlodipine. This highlighted a possible clue that can be used to clinically distinguish a drug-induced case from an idiopathic disorder. A 92-year-old Japanese woman presented with a 2-month history of progressive erythematous, papulosquamous rash, and annular plaques in non-sun-exposed sites with no systemic symptoms. Irbesartan/amlodipine besilate combination tablets were prescribed 8 months earlier for hypertension. The appearance of the skin eruptions, results of immunopathological findings, and temporal relationship between the rash and drugs were suggestive of a diagnosis of drug-induced SCLE, which was confirmed by the spontaneous resolution of these cutaneous eruptions within 4 weeks after cessation of amlodipine treatment. The evaluation of possible associations with medications should be performed in patients presenting with clinical features characterizing SCLE in atypical sites (non-sun-exposed areas).</description><identifier>ISSN: 1662-6567</identifier><identifier>EISSN: 1662-6567</identifier><identifier>DOI: 10.1159/000524001</identifier><identifier>PMID: 35496508</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>adverse drug reaction ; Amlodipine ; Antibodies ; Antigens ; Antihypertensives ; Antilipemic agents ; Biopsy ; calcium channel blocker ; Calcium channels ; case report ; Case reports ; Drug withdrawal ; Drugs ; Hypertension ; Lupus ; Lupus erythematosus ; Patients ; Serology ; Single Case ; Skin ; subacute cutaneous lupus erythematosus</subject><ispartof>Case Reports in Dermatology, 2022-03, Vol.14 (1), p.71-76</ispartof><rights>2022 The Author(s). Published by S. Karger AG, Basel</rights><rights>Copyright © 2022 by S. 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Karger AG, Basel 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4671-208b3e9313bb475f18af7af9d8ad985e84a203f1c6808a7842172fc34e512ea63</citedby><orcidid>0000-0003-4868-968X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995664/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995664/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,27635,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35496508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mizuta, Takahiro</creatorcontrib><creatorcontrib>Kato, Miyuki</creatorcontrib><title>Amlodipine-Induced Subacute Cutaneous Lupus Erythematosus Localized to Non-Sun-Exposed Areas</title><title>Case Reports in Dermatology</title><addtitle>Case Rep Dermatol</addtitle><description>The cutaneous manifestations of subacute cutaneous lupus erythematosus (SCLE), a subset of cutaneous lupus erythematosus, arise most often in sun-exposed areas. We report a case of SCLE with atypical distribution, following treatment with amlodipine. This highlighted a possible clue that can be used to clinically distinguish a drug-induced case from an idiopathic disorder. A 92-year-old Japanese woman presented with a 2-month history of progressive erythematous, papulosquamous rash, and annular plaques in non-sun-exposed sites with no systemic symptoms. Irbesartan/amlodipine besilate combination tablets were prescribed 8 months earlier for hypertension. The appearance of the skin eruptions, results of immunopathological findings, and temporal relationship between the rash and drugs were suggestive of a diagnosis of drug-induced SCLE, which was confirmed by the spontaneous resolution of these cutaneous eruptions within 4 weeks after cessation of amlodipine treatment. The evaluation of possible associations with medications should be performed in patients presenting with clinical features characterizing SCLE in atypical sites (non-sun-exposed areas).</description><subject>adverse drug reaction</subject><subject>Amlodipine</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Antihypertensives</subject><subject>Antilipemic agents</subject><subject>Biopsy</subject><subject>calcium channel blocker</subject><subject>Calcium channels</subject><subject>case report</subject><subject>Case reports</subject><subject>Drug withdrawal</subject><subject>Drugs</subject><subject>Hypertension</subject><subject>Lupus</subject><subject>Lupus erythematosus</subject><subject>Patients</subject><subject>Serology</subject><subject>Single Case</subject><subject>Skin</subject><subject>subacute cutaneous lupus erythematosus</subject><issn>1662-6567</issn><issn>1662-6567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DOA</sourceid><recordid>eNptks-L1DAUx4so7rp68C4y4MlD1_xuehGGcdSBQQ-rNyG85sdsx7bpJo24_vVm7DjuggSS8PJ9n3xf8oriOUaXGPP6DUKIE4YQflCcYyFIKbioHt7ZnxVPYtwjJGou6OPijHJWC47kefFt2XfetGM72HIzmKStWVylBnSa7GKVJhisT3GxTWOe1-F2urY9TD4eYl5D1_7KCZNffPJDeZWGcv1z9DGHlsFCfFo8ctBF--y4XhRf36-_rD6W288fNqvlttRMVLgkSDbU1hTTpmEVd1iCq8DVRoKpJbeSAUHUYS0kklBJRnBFnKbMckwsCHpRbGau8bBXY2h7CLfKQ6v-BHzYKQhTqzurDHBHScMNqjCTFZUgM6jRpsHcGAKZ9XZmjanprdF2mAJ096D3T4b2Wu38DyXr_LiCZcCrIyD4m2TjpPY-hSHXr4jgtZASo4Ply1m1g-yqHZzPMJ2HsX2r_WBdm-PLChHOGa1oTng9J-jgYwzWnSxhpA5doE5dkLUv79ZwUv799n8ev0PY2XASrN6tZ4QajcuqF_9VHW_5DUmNwVU</recordid><startdate>20220329</startdate><enddate>20220329</enddate><creator>Mizuta, Takahiro</creator><creator>Kato, Miyuki</creator><general>S. Karger AG</general><general>Karger Publishers</general><scope>M--</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4868-968X</orcidid></search><sort><creationdate>20220329</creationdate><title>Amlodipine-Induced Subacute Cutaneous Lupus Erythematosus Localized to Non-Sun-Exposed Areas</title><author>Mizuta, Takahiro ; Kato, Miyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4671-208b3e9313bb475f18af7af9d8ad985e84a203f1c6808a7842172fc34e512ea63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>adverse drug reaction</topic><topic>Amlodipine</topic><topic>Antibodies</topic><topic>Antigens</topic><topic>Antihypertensives</topic><topic>Antilipemic agents</topic><topic>Biopsy</topic><topic>calcium channel blocker</topic><topic>Calcium channels</topic><topic>case report</topic><topic>Case reports</topic><topic>Drug withdrawal</topic><topic>Drugs</topic><topic>Hypertension</topic><topic>Lupus</topic><topic>Lupus erythematosus</topic><topic>Patients</topic><topic>Serology</topic><topic>Single Case</topic><topic>Skin</topic><topic>subacute cutaneous lupus erythematosus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mizuta, Takahiro</creatorcontrib><creatorcontrib>Kato, Miyuki</creatorcontrib><collection>Karger Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Case Reports in Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mizuta, Takahiro</au><au>Kato, Miyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amlodipine-Induced Subacute Cutaneous Lupus Erythematosus Localized to Non-Sun-Exposed Areas</atitle><jtitle>Case Reports in Dermatology</jtitle><addtitle>Case Rep Dermatol</addtitle><date>2022-03-29</date><risdate>2022</risdate><volume>14</volume><issue>1</issue><spage>71</spage><epage>76</epage><pages>71-76</pages><issn>1662-6567</issn><eissn>1662-6567</eissn><abstract>The cutaneous manifestations of subacute cutaneous lupus erythematosus (SCLE), a subset of cutaneous lupus erythematosus, arise most often in sun-exposed areas. 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| subjects | adverse drug reaction Amlodipine Antibodies Antigens Antihypertensives Antilipemic agents Biopsy calcium channel blocker Calcium channels case report Case reports Drug withdrawal Drugs Hypertension Lupus Lupus erythematosus Patients Serology Single Case Skin subacute cutaneous lupus erythematosus |
| title | Amlodipine-Induced Subacute Cutaneous Lupus Erythematosus Localized to Non-Sun-Exposed Areas |
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