A single-cell atlas of the normal and malformed human brain vasculature

Cerebrovascular diseases are a leading cause of death and neurologic disability. Further understanding of disease mechanisms and therapeutic strategies requires a deeper knowledge of cerebrovascular cells in humans. We profiled transcriptomes of 181,388 cells to define a cell atlas of the adult huma...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2022-03, Vol.375 (6584), p.eabi7377-eabi7377
Hauptverfasser:	Winkler, Ethan A, Kim, Chang N, Ross, Jayden M, Garcia, Joseph H, Gil, Eugene, Oh, Irene, Chen, Lindsay Q, Wu, David, Catapano, Joshua S, Raygor, Kunal, Narsinh, Kazim, Kim, Helen, Weinsheimer, Shantel, Cooke, Daniel L, Walcott, Brian P, Lawton, Michael T, Gupta, Nalin, Zlokovic, Berislav V, Chang, Edward F, Abla, Adib A, Lim, Daniel A, Nowakowski, Tomasz J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Angiogenesis Arteries Biomarkers Blood vessels Blood Vessels - cytology Blood Vessels - pathology Blood Vessels - physiology Blood Vessels - physiopathology Brain Brain - blood supply Brain mapping Capillaries Cell culture Cell interactions Cells, Cultured Cerebral Cortex - blood supply Cerebral Hemorrhage - pathology Cerebral Hemorrhage - physiopathology Cerebrovascular Circulation Cerebrovascular diseases Comparative analysis Crosstalk Death Depletion Drug development Endothelial cells Endothelial Cells - cytology Endothelial Cells - pathology Endothelial Cells - physiology Endothelium Fibroblasts Fibroblasts - cytology Fibroblasts - physiology Fluorescence Fluorescence in situ hybridization Gene expression Gene sequencing Heterogeneity Humans Immune system Inflammation Intracranial Arteriovenous Malformations - metabolism Intracranial Arteriovenous Malformations - pathology Monocytes Monocytes - cytology Monocytes - physiology Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - pathology Muscle, Smooth, Vascular - physiology Muscles Neuronal-glial interactions Pericytes Pericytes - cytology Pericytes - physiology Perturbation RNA-Seq Single-Cell Analysis Smooth muscle Spatial distribution Specialization Stroke Therapeutic targets Transcription Transcriptome Vascular diseases Young adults Zonation
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