Effectiveness of preoperative bath using chloroxylenol antiseptic soap on the incidence of post emergency cesarean section surgical site infection at Mbarara Regional Referral hospital, Uganda: a randomized controlled trial
Surgical Site Infections (SSIs) constitute 15%-45% of hospital acquired infections in sub-Saharan Africa. Cesarean section (CS) increases the risk of developing sepsis by 5-20 times and is highest when the operation is emergency. Therefore, the purpose of this study was to measure the effect of chlo...
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| Veröffentlicht in: | The Pan African medical journal 2022, Vol.41, p.92-92 |
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| creator | Lukabwe, Henry Kajabwangu, Rodgers Mugisha, Dale Mayengo, Horace Munyanderu, Baraka Baluku, Asanairi Manyang, Anthony Lapat, Jolly Joe Banya, Francis Kayondo, Musa Mayanja, Ronald Muhumuza, Joy Bajunirwe, Francis Ngonzi, Joseph |
| description | Surgical Site Infections (SSIs) constitute 15%-45% of hospital acquired infections in sub-Saharan Africa. Cesarean section (CS) increases the risk of developing sepsis by 5-20 times and is highest when the operation is emergency. Therefore, the purpose of this study was to measure the effect of chloroxylenol in reducing the incidence of post cesarean SSIs at Mbarara Regional Referral Hospital (MRRH).
a randomized controlled trial was conducted at MRRH maternity ward and mothers were randomized into either control or intervention arms. The intervention was a complete body bath with chloroxylenol antiseptic soap before the operation, while the control arm participants received a standard ward pre-operative preparation procedures. All participants were followed up for 30 days and assessed using an SSI screening tool.
ninety-six women were randomized, and 48 were assigned to each arm. The overall incidence of SSI was 30.21%. The incidence of SSI was significantly lower in the intervention compared to the control arm (6.25% in the intervention arm versus 54.17% in the control arm) (p-value |
| doi_str_mv | 10.11604/pamj.2022.41.92.23687 |
| format | Article |
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a randomized controlled trial was conducted at MRRH maternity ward and mothers were randomized into either control or intervention arms. The intervention was a complete body bath with chloroxylenol antiseptic soap before the operation, while the control arm participants received a standard ward pre-operative preparation procedures. All participants were followed up for 30 days and assessed using an SSI screening tool.
ninety-six women were randomized, and 48 were assigned to each arm. The overall incidence of SSI was 30.21%. The incidence of SSI was significantly lower in the intervention compared to the control arm (6.25% in the intervention arm versus 54.17% in the control arm) (p-value <0.001). Chloroxylenol bath was protective of SSI with a 90% risk reduction for SSI (95% confidence interval of 67%-97%).
a preoperative bath with chloroxylenol for pregnant mothers is associated with a significantly lower risk of post cesarean section surgical site infections. Health facilities with a high burden of post SSI should consider adding this simple and effective intervention to the existing infection prevention measures. Clinical Trials.gov registration (NCT03544710).</description><identifier>ISSN: 1937-8688</identifier><identifier>EISSN: 1937-8688</identifier><identifier>DOI: 10.11604/pamj.2022.41.92.23687</identifier><identifier>PMID: 35465375</identifier><language>eng</language><publisher>Uganda: The African Field Epidemiology Network</publisher><subject>Anti-Infective Agents, Local ; Cesarean Section ; Female ; Hospitals ; Humans ; Incidence ; Pregnancy ; Referral and Consultation ; Soaps ; Surgical Wound Infection - drug therapy ; Surgical Wound Infection - epidemiology ; Surgical Wound Infection - prevention & control ; Uganda ; Xylenes</subject><ispartof>The Pan African medical journal, 2022, Vol.41, p.92-92</ispartof><rights>Copyright: Henry Lukabwe et al.</rights><rights>Henry Lukabwe et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994462/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994462/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4014,27914,27915,27916,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35465375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lukabwe, Henry</creatorcontrib><creatorcontrib>Kajabwangu, Rodgers</creatorcontrib><creatorcontrib>Mugisha, Dale</creatorcontrib><creatorcontrib>Mayengo, Horace</creatorcontrib><creatorcontrib>Munyanderu, Baraka</creatorcontrib><creatorcontrib>Baluku, Asanairi</creatorcontrib><creatorcontrib>Manyang, Anthony</creatorcontrib><creatorcontrib>Lapat, Jolly Joe</creatorcontrib><creatorcontrib>Banya, Francis</creatorcontrib><creatorcontrib>Kayondo, Musa</creatorcontrib><creatorcontrib>Mayanja, Ronald</creatorcontrib><creatorcontrib>Muhumuza, Joy</creatorcontrib><creatorcontrib>Bajunirwe, Francis</creatorcontrib><creatorcontrib>Ngonzi, Joseph</creatorcontrib><title>Effectiveness of preoperative bath using chloroxylenol antiseptic soap on the incidence of post emergency cesarean section surgical site infection at Mbarara Regional Referral hospital, Uganda: a randomized controlled trial</title><title>The Pan African medical journal</title><addtitle>Pan Afr Med J</addtitle><description>Surgical Site Infections (SSIs) constitute 15%-45% of hospital acquired infections in sub-Saharan Africa. Cesarean section (CS) increases the risk of developing sepsis by 5-20 times and is highest when the operation is emergency. Therefore, the purpose of this study was to measure the effect of chloroxylenol in reducing the incidence of post cesarean SSIs at Mbarara Regional Referral Hospital (MRRH).
a randomized controlled trial was conducted at MRRH maternity ward and mothers were randomized into either control or intervention arms. The intervention was a complete body bath with chloroxylenol antiseptic soap before the operation, while the control arm participants received a standard ward pre-operative preparation procedures. All participants were followed up for 30 days and assessed using an SSI screening tool.
ninety-six women were randomized, and 48 were assigned to each arm. The overall incidence of SSI was 30.21%. The incidence of SSI was significantly lower in the intervention compared to the control arm (6.25% in the intervention arm versus 54.17% in the control arm) (p-value <0.001). Chloroxylenol bath was protective of SSI with a 90% risk reduction for SSI (95% confidence interval of 67%-97%).
a preoperative bath with chloroxylenol for pregnant mothers is associated with a significantly lower risk of post cesarean section surgical site infections. Health facilities with a high burden of post SSI should consider adding this simple and effective intervention to the existing infection prevention measures. Clinical Trials.gov registration (NCT03544710).</description><subject>Anti-Infective Agents, Local</subject><subject>Cesarean Section</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Incidence</subject><subject>Pregnancy</subject><subject>Referral and Consultation</subject><subject>Soaps</subject><subject>Surgical Wound Infection - drug therapy</subject><subject>Surgical Wound Infection - epidemiology</subject><subject>Surgical Wound Infection - prevention & control</subject><subject>Uganda</subject><subject>Xylenes</subject><issn>1937-8688</issn><issn>1937-8688</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUt1qFDEYHUSxtfoKJZdeuGv-Z-KFIKX-QEUo9jpkMt_MpmSSMcmWri_rq5jdrqUSSA4n55zvuzhNc07wmhCJ-fvFzLdriildc7JWdE2Z7NpnzSlRrF11suueP8EnzaucbzGWsmP4ZXPCBJeCteK0-XM5jmCLu4MAOaM4oiVBXCCZPYd6UzZom12YkN34mOL9zkOIHplQXIalOItyNAuKAZUNIBesGyBYOCTFXBDMkKbK7JCFbBKYgPJ-YDXkbZqcNR5lV_bW8cibgr73JtWDrmGqTJVcwwgpVbCJeXHF-HfoZjJhMB-QQamCOLvfMCAbQ0nR-wpLcsa_bl6Mxmd4c3zPmpvPlz8vvq6ufnz5dvHpamWpImVFeiwYt6RedOzJQCWjrVBWiE4wZbAwuONWMc7H3owWKtm3uOc9V3LohWRnzceH3GXbzzBYqGsYr5fkZpN2Ohqn__8JbqOneKc7pTiXtAa8PQak-GsLuejZZQvemwBxmzWVQhDcKoarVD5IbYo5JxgfxxCsD-3Q-3bofTs0J1pRfWhHNZ4_XfLR9q8O7C__pb72</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Lukabwe, Henry</creator><creator>Kajabwangu, Rodgers</creator><creator>Mugisha, Dale</creator><creator>Mayengo, Horace</creator><creator>Munyanderu, Baraka</creator><creator>Baluku, Asanairi</creator><creator>Manyang, Anthony</creator><creator>Lapat, Jolly Joe</creator><creator>Banya, Francis</creator><creator>Kayondo, Musa</creator><creator>Mayanja, Ronald</creator><creator>Muhumuza, Joy</creator><creator>Bajunirwe, Francis</creator><creator>Ngonzi, Joseph</creator><general>The African Field Epidemiology Network</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2022</creationdate><title>Effectiveness of preoperative bath using chloroxylenol antiseptic soap on the incidence of post emergency cesarean section surgical site infection at Mbarara Regional Referral hospital, Uganda: a randomized controlled trial</title><author>Lukabwe, Henry ; Kajabwangu, Rodgers ; Mugisha, Dale ; Mayengo, Horace ; Munyanderu, Baraka ; Baluku, Asanairi ; Manyang, Anthony ; Lapat, Jolly Joe ; Banya, Francis ; Kayondo, Musa ; Mayanja, Ronald ; Muhumuza, Joy ; Bajunirwe, Francis ; Ngonzi, Joseph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c291t-1b0534c15342fb1d2632759c558539a05a084c9344fbafce539b70b4b496db563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anti-Infective Agents, Local</topic><topic>Cesarean Section</topic><topic>Female</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Incidence</topic><topic>Pregnancy</topic><topic>Referral and Consultation</topic><topic>Soaps</topic><topic>Surgical Wound Infection - drug therapy</topic><topic>Surgical Wound Infection - epidemiology</topic><topic>Surgical Wound Infection - prevention & control</topic><topic>Uganda</topic><topic>Xylenes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lukabwe, Henry</creatorcontrib><creatorcontrib>Kajabwangu, Rodgers</creatorcontrib><creatorcontrib>Mugisha, Dale</creatorcontrib><creatorcontrib>Mayengo, Horace</creatorcontrib><creatorcontrib>Munyanderu, Baraka</creatorcontrib><creatorcontrib>Baluku, Asanairi</creatorcontrib><creatorcontrib>Manyang, Anthony</creatorcontrib><creatorcontrib>Lapat, Jolly Joe</creatorcontrib><creatorcontrib>Banya, Francis</creatorcontrib><creatorcontrib>Kayondo, Musa</creatorcontrib><creatorcontrib>Mayanja, Ronald</creatorcontrib><creatorcontrib>Muhumuza, Joy</creatorcontrib><creatorcontrib>Bajunirwe, Francis</creatorcontrib><creatorcontrib>Ngonzi, Joseph</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Pan African medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lukabwe, Henry</au><au>Kajabwangu, Rodgers</au><au>Mugisha, Dale</au><au>Mayengo, Horace</au><au>Munyanderu, Baraka</au><au>Baluku, Asanairi</au><au>Manyang, Anthony</au><au>Lapat, Jolly Joe</au><au>Banya, Francis</au><au>Kayondo, Musa</au><au>Mayanja, Ronald</au><au>Muhumuza, Joy</au><au>Bajunirwe, Francis</au><au>Ngonzi, Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of preoperative bath using chloroxylenol antiseptic soap on the incidence of post emergency cesarean section surgical site infection at Mbarara Regional Referral hospital, Uganda: a randomized controlled trial</atitle><jtitle>The Pan African medical journal</jtitle><addtitle>Pan Afr Med J</addtitle><date>2022</date><risdate>2022</risdate><volume>41</volume><spage>92</spage><epage>92</epage><pages>92-92</pages><issn>1937-8688</issn><eissn>1937-8688</eissn><abstract>Surgical Site Infections (SSIs) constitute 15%-45% of hospital acquired infections in sub-Saharan Africa. Cesarean section (CS) increases the risk of developing sepsis by 5-20 times and is highest when the operation is emergency. Therefore, the purpose of this study was to measure the effect of chloroxylenol in reducing the incidence of post cesarean SSIs at Mbarara Regional Referral Hospital (MRRH).
a randomized controlled trial was conducted at MRRH maternity ward and mothers were randomized into either control or intervention arms. The intervention was a complete body bath with chloroxylenol antiseptic soap before the operation, while the control arm participants received a standard ward pre-operative preparation procedures. All participants were followed up for 30 days and assessed using an SSI screening tool.
ninety-six women were randomized, and 48 were assigned to each arm. The overall incidence of SSI was 30.21%. The incidence of SSI was significantly lower in the intervention compared to the control arm (6.25% in the intervention arm versus 54.17% in the control arm) (p-value <0.001). Chloroxylenol bath was protective of SSI with a 90% risk reduction for SSI (95% confidence interval of 67%-97%).
a preoperative bath with chloroxylenol for pregnant mothers is associated with a significantly lower risk of post cesarean section surgical site infections. Health facilities with a high burden of post SSI should consider adding this simple and effective intervention to the existing infection prevention measures. Clinical Trials.gov registration (NCT03544710).</abstract><cop>Uganda</cop><pub>The African Field Epidemiology Network</pub><pmid>35465375</pmid><doi>10.11604/pamj.2022.41.92.23687</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1937-8688 |
| ispartof | The Pan African medical journal, 2022, Vol.41, p.92-92 |
| issn | 1937-8688 1937-8688 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; African Journals Online (Open Access); PubMed Central |
| subjects | Anti-Infective Agents, Local Cesarean Section Female Hospitals Humans Incidence Pregnancy Referral and Consultation Soaps Surgical Wound Infection - drug therapy Surgical Wound Infection - epidemiology Surgical Wound Infection - prevention & control Uganda Xylenes |
| title | Effectiveness of preoperative bath using chloroxylenol antiseptic soap on the incidence of post emergency cesarean section surgical site infection at Mbarara Regional Referral hospital, Uganda: a randomized controlled trial |
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