Autonomic disorders and myocardial 123I-metaiodobenzylguanidine scintigraphy in Huntington’s disease
Huntington’s disease (HD) patients often present with abnormal modulation of blood pressure and heart rate. We investigated whether cardiac autonomic innervation assessed by 123I-metaiodobenzylguanidine (MIBG) imaging is impaired in HD patients, in comparison with controls (Ctrl). Fifteen patients (...
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| Veröffentlicht in: | Journal of nuclear cardiology 2022-04, Vol.29 (2), p.642-648 |
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| creator | Assante, Roberta Salvatore, Elena Nappi, Carmela Peluso, Silvio De Simini, Giovanni Di Maio, Luigi Palmieri, Gianluigi Rosario Ferrara, Isabella Pia Roca, Alessandro De Michele, Giuseppe Cuocolo, Alberto Pappatà, Sabina De Rosa, Anna |
| description | Huntington’s disease (HD) patients often present with abnormal modulation of blood pressure and heart rate. We investigated whether cardiac autonomic innervation assessed by 123I-metaiodobenzylguanidine (MIBG) imaging is impaired in HD patients, in comparison with controls (Ctrl).
Fifteen patients (6 F and 9 M) were assessed by the motor section of the Unified HD Rating Scale, the Total Function Capacity, and the scale for outcomes in Parkinson’s disease-autonomic (SCOPA-AUT) questionnaire. All patients and 10 Ctrl (5 F and 5 M) underwent 123I-MIBG imaging. From planar images, the early and late heart-to-mediastinum (H/M) ratios and myocardial washout rates (WR) were calculated.
We did not find significant differences in early and late H/M ratios and WR between the two groups. At individual level, three patients showed reduced early and/or late H/M ratios. The most common autonomic complaints were gastrointestinal and genitourinary disorders. SCOPA-AUT questionnaire score results positively correlated with the disease duration and WR.
Our study indicates that myocardial postganglionic sympathetic innervation is essentially preserved or only minimally involved in HD. These findings suggest that the cardiovascular dysfunction might be mainly due to the impairment of brain areas associated with the regulation and modulation of the heart function. |
| doi_str_mv | 10.1007/s12350-020-02299-7 |
| format | Article |
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Fifteen patients (6 F and 9 M) were assessed by the motor section of the Unified HD Rating Scale, the Total Function Capacity, and the scale for outcomes in Parkinson’s disease-autonomic (SCOPA-AUT) questionnaire. All patients and 10 Ctrl (5 F and 5 M) underwent 123I-MIBG imaging. From planar images, the early and late heart-to-mediastinum (H/M) ratios and myocardial washout rates (WR) were calculated.
We did not find significant differences in early and late H/M ratios and WR between the two groups. At individual level, three patients showed reduced early and/or late H/M ratios. The most common autonomic complaints were gastrointestinal and genitourinary disorders. SCOPA-AUT questionnaire score results positively correlated with the disease duration and WR.
Our study indicates that myocardial postganglionic sympathetic innervation is essentially preserved or only minimally involved in HD. These findings suggest that the cardiovascular dysfunction might be mainly due to the impairment of brain areas associated with the regulation and modulation of the heart function.</description><identifier>ISSN: 1071-3581</identifier><identifier>EISSN: 1532-6551</identifier><identifier>DOI: 10.1007/s12350-020-02299-7</identifier><identifier>PMID: 32803674</identifier><language>eng</language><publisher>Cham: Elsevier Inc</publisher><subject>3-Iodobenzylguanidine ; autonomic disorders ; Autonomic Nervous System Diseases - diagnostic imaging ; Cardiology ; Heart - innervation ; Humans ; Huntington Disease - diagnostic imaging ; Huntingtons disease ; Huntington’s disease ; Imaging ; Iodine Radioisotopes ; Medicine ; Medicine & Public Health ; MIBG ; Myocardial Perfusion Imaging ; Nuclear Medicine ; Original ; Original Article ; Questionnaires ; Radiology ; Radiopharmaceuticals ; scintigraphy</subject><ispartof>Journal of nuclear cardiology, 2022-04, Vol.29 (2), p.642-648</ispartof><rights>2022 THE AUTHORS. Published by ELSEVIER INC. on behalf of American Society of Nuclear Cardiology</rights><rights>The Author(s) 2020</rights><rights>2020. The Author(s).</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-c0929229e4a3de961ea099f082d08ebfa6354390456da3d1843fa5e0582e8f0a3</citedby><cites>FETCH-LOGICAL-c527t-c0929229e4a3de961ea099f082d08ebfa6354390456da3d1843fa5e0582e8f0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12350-020-02299-7$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12350-020-02299-7$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32803674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Assante, Roberta</creatorcontrib><creatorcontrib>Salvatore, Elena</creatorcontrib><creatorcontrib>Nappi, Carmela</creatorcontrib><creatorcontrib>Peluso, Silvio</creatorcontrib><creatorcontrib>De Simini, Giovanni</creatorcontrib><creatorcontrib>Di Maio, Luigi</creatorcontrib><creatorcontrib>Palmieri, Gianluigi Rosario</creatorcontrib><creatorcontrib>Ferrara, Isabella Pia</creatorcontrib><creatorcontrib>Roca, Alessandro</creatorcontrib><creatorcontrib>De Michele, Giuseppe</creatorcontrib><creatorcontrib>Cuocolo, Alberto</creatorcontrib><creatorcontrib>Pappatà, Sabina</creatorcontrib><creatorcontrib>De Rosa, Anna</creatorcontrib><title>Autonomic disorders and myocardial 123I-metaiodobenzylguanidine scintigraphy in Huntington’s disease</title><title>Journal of nuclear cardiology</title><addtitle>J. Nucl. Cardiol</addtitle><addtitle>J Nucl Cardiol</addtitle><description>Huntington’s disease (HD) patients often present with abnormal modulation of blood pressure and heart rate. We investigated whether cardiac autonomic innervation assessed by 123I-metaiodobenzylguanidine (MIBG) imaging is impaired in HD patients, in comparison with controls (Ctrl).
Fifteen patients (6 F and 9 M) were assessed by the motor section of the Unified HD Rating Scale, the Total Function Capacity, and the scale for outcomes in Parkinson’s disease-autonomic (SCOPA-AUT) questionnaire. All patients and 10 Ctrl (5 F and 5 M) underwent 123I-MIBG imaging. From planar images, the early and late heart-to-mediastinum (H/M) ratios and myocardial washout rates (WR) were calculated.
We did not find significant differences in early and late H/M ratios and WR between the two groups. At individual level, three patients showed reduced early and/or late H/M ratios. The most common autonomic complaints were gastrointestinal and genitourinary disorders. SCOPA-AUT questionnaire score results positively correlated with the disease duration and WR.
Our study indicates that myocardial postganglionic sympathetic innervation is essentially preserved or only minimally involved in HD. These findings suggest that the cardiovascular dysfunction might be mainly due to the impairment of brain areas associated with the regulation and modulation of the heart function.</description><subject>3-Iodobenzylguanidine</subject><subject>autonomic disorders</subject><subject>Autonomic Nervous System Diseases - diagnostic imaging</subject><subject>Cardiology</subject><subject>Heart - innervation</subject><subject>Humans</subject><subject>Huntington Disease - diagnostic imaging</subject><subject>Huntingtons disease</subject><subject>Huntington’s disease</subject><subject>Imaging</subject><subject>Iodine Radioisotopes</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>MIBG</subject><subject>Myocardial Perfusion Imaging</subject><subject>Nuclear Medicine</subject><subject>Original</subject><subject>Original Article</subject><subject>Questionnaires</subject><subject>Radiology</subject><subject>Radiopharmaceuticals</subject><subject>scintigraphy</subject><issn>1071-3581</issn><issn>1532-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhSMEoqXwAixQJDZsAuO_xJYQUlUVWqkSG1hbvvYkdZXYFzupdLviNXg9nqS-pJSfRReWPZpzznj0VdVLAm8JQPcuE8oENED3hyrVdI-qQyIYbVohyOPyho40TEhyUD3L-QoAFFPqaXXAqATWdvyw6o-XOYY4eVs7n2NymHJtgqunXbQmOW_Guow5byacjY8ubjDc7MZhMcE7H7DO1ofZD8lsL3e1D_XZUsowlNCf33_kfSiajM-rJ70ZM764u4-qrx9Pv5ycNRefP52fHF80VtBubiwoqsoqyA1zqFqCBpTqQVIHEje9aZngTAEXrSsKIjnrjUAQkqLswbCj6sOau102EzqLYU5m1NvkJ5N2Ohqv_-0Ef6mHeK2lUqwjvAS8uQtI8duCedaTzxbH0QSMS9aUM95xySQp0tf_Sa_ikkJZT9OWSyEok6yo6KqyKeacsL__DAG9x6hXjLpg1L8w6q6YXv29xr3lN7ciYKsgl1YYMP2Z_WDs-9WFBcG1L65CD4NF5xPaWbvoH7LfAhZbvoM</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Assante, Roberta</creator><creator>Salvatore, Elena</creator><creator>Nappi, Carmela</creator><creator>Peluso, Silvio</creator><creator>De Simini, Giovanni</creator><creator>Di Maio, Luigi</creator><creator>Palmieri, Gianluigi Rosario</creator><creator>Ferrara, Isabella Pia</creator><creator>Roca, Alessandro</creator><creator>De Michele, Giuseppe</creator><creator>Cuocolo, Alberto</creator><creator>Pappatà, Sabina</creator><creator>De Rosa, Anna</creator><general>Elsevier Inc</general><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220401</creationdate><title>Autonomic disorders and myocardial 123I-metaiodobenzylguanidine scintigraphy in Huntington’s disease</title><author>Assante, Roberta ; 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Nucl. Cardiol</stitle><addtitle>J Nucl Cardiol</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>29</volume><issue>2</issue><spage>642</spage><epage>648</epage><pages>642-648</pages><issn>1071-3581</issn><eissn>1532-6551</eissn><abstract>Huntington’s disease (HD) patients often present with abnormal modulation of blood pressure and heart rate. We investigated whether cardiac autonomic innervation assessed by 123I-metaiodobenzylguanidine (MIBG) imaging is impaired in HD patients, in comparison with controls (Ctrl).
Fifteen patients (6 F and 9 M) were assessed by the motor section of the Unified HD Rating Scale, the Total Function Capacity, and the scale for outcomes in Parkinson’s disease-autonomic (SCOPA-AUT) questionnaire. All patients and 10 Ctrl (5 F and 5 M) underwent 123I-MIBG imaging. From planar images, the early and late heart-to-mediastinum (H/M) ratios and myocardial washout rates (WR) were calculated.
We did not find significant differences in early and late H/M ratios and WR between the two groups. At individual level, three patients showed reduced early and/or late H/M ratios. The most common autonomic complaints were gastrointestinal and genitourinary disorders. SCOPA-AUT questionnaire score results positively correlated with the disease duration and WR.
Our study indicates that myocardial postganglionic sympathetic innervation is essentially preserved or only minimally involved in HD. These findings suggest that the cardiovascular dysfunction might be mainly due to the impairment of brain areas associated with the regulation and modulation of the heart function.</abstract><cop>Cham</cop><pub>Elsevier Inc</pub><pmid>32803674</pmid><doi>10.1007/s12350-020-02299-7</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 3-Iodobenzylguanidine autonomic disorders Autonomic Nervous System Diseases - diagnostic imaging Cardiology Heart - innervation Humans Huntington Disease - diagnostic imaging Huntingtons disease Huntington’s disease Imaging Iodine Radioisotopes Medicine Medicine & Public Health MIBG Myocardial Perfusion Imaging Nuclear Medicine Original Original Article Questionnaires Radiology Radiopharmaceuticals scintigraphy |
| title | Autonomic disorders and myocardial 123I-metaiodobenzylguanidine scintigraphy in Huntington’s disease |
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