Lower polyunsaturated fatty acid levels and FADS2 expression in adult compared to neonatal keratinocytes are associated with FADS2 promotor hypermethylation

Keratinocytes produce lipids that are critical for the skin barrier, however, little is known about the impact of age on fatty acid (FA) biosynthesis in these cells. We have examined the relationship between keratinocyte FA composition, lipid biosynthetic gene expression, gene promoter methylation a...

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Veröffentlicht in:	Biochemical and biophysical research communications 2022-04, Vol.601, p.9-15
Hauptverfasser:	Pararasa, C., Messenger, D.J., Barrett, K.E., Hyliands, D., Talbot, D., Fowler, M.I., Kawatra, T., Gunn, D.A., Lim, F.L., Wainwright, L.J., Jenkins, G., Griffiths, H.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult adults biosynthesis Delta-5 Fatty Acid Desaturase DNA Helicases - metabolism DNA Methylation Epigenetic Fatty acid Fatty Acid Desaturases - genetics Fatty Acid Desaturases - metabolism Fatty Acids, Unsaturated - metabolism GC-MS gene expression genes genomics Humans Infant, Newborn Keratinocytes Keratinocytes - metabolism loci methylation mRNA Nuclear Proteins - metabolism polyunsaturated fatty acids Promoter Regions, Genetic SMARCA4 Transcription Factors - metabolism
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