The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling

The volume-regulated anion channel (VRAC) is formed by LRRC8 proteins and is responsible for the regulatory volume decrease (RVD) after hypotonic cell swelling. Besides chloride, VRAC transports other molecules, for example, immunomodulatory cyclic dinucleotides (CDNs) including 2′3′cGAMP. Here, we...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature immunology 2022-02, Vol.23 (2), p.287-302
Hauptverfasser:	Concepcion, Axel R., Wagner, Larry E., Zhu, Jingjie, Tao, Anthony Y., Yang, Jun, Khodadadi-Jamayran, Alireza, Wang, Yin-Hu, Liu, Menghan, Rose, Rebecca E., Jones, Drew R., Coetzee, William A., Yule, David I., Feske, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554 631/250/516 Adaptive immunity Animals Anions - metabolism Biomedical and Life Sciences Biomedicine Calcium - metabolism Calcium influx Cell cycle Cell proliferation Cell size Cell survival Clonal deletion Cytokines Dinucleoside Phosphates - metabolism Experimental allergic encephalomyelitis Female Immunology Immunomodulation Infectious Diseases Influenza A Ion Channels - metabolism Kinases Lymphocytes Lymphocytes T Membrane Proteins - metabolism Mice Mice, Inbred C57BL Nucleotides, Cyclic - metabolism p53 Protein Phenotypes Signal transduction Signal Transduction - physiology T-Lymphocytes - metabolism Tumor Suppressor Protein p53 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!