The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes

Small-molecule discovery typically involves large-scale screening campaigns, spanning multiple compound collections. However, such activities can be cost- or time-prohibitive, especially when using complex assay systems, limiting the number of compounds tested. Further, low hit rates can make the pr...

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Veröffentlicht in:	SLAS discovery 2021-08, Vol.26 (7), p.855-861
Hauptverfasser:	Clemons, Paul A., Bittker, Joshua A., Wagner, Florence F., Hands, Allison, Dančík, Vlado, Schreiber, Stuart L., Choudhary, Amit, Wagner, Bridget K.
Format:	Artikel
Sprache:	eng
Schlagworte:	chemoinformatics compound repositories Drug Discovery - methods Drug Evaluation, Preclinical - methods general pharmaceutical process high-content screening Humans Small Molecule Libraries Structure-Activity Relationship
Online-Zugang:	Volltext
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