Protein kinase Cα activation switches YAP1 from TEAD‐mediated signaling to p73‐mediated signaling

Yes‐associated protein 1 (YAP1) interacts with TEAD transcription factor in the nucleus and upregulates TEAD‐target genes. YAP1 is phosphorylated by large tumor suppressor (LATS) kinases, the core kinases of the Hippo pathway, at 5 serine residues and is sequestered and degraded in the cytoplasm. In...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer science 2022-04, Vol.113 (4), p.1305-1320
Hauptverfasser:	Sinclear, Caleb Kwame, Maruyama, Junichi, Nagashima, Shunta, Arimoto‐Matsuzaki, Kyoko, Kuleape, Joshua Agbemefa, Iwasa, Hiroaki, Nishina, Hiroshi, Hata, Yutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis Bryostatins Cancer Cold Cold shock proteins Cooperativity Cytoplasm Fractionation Hippo pathway Humans Kinases Original ORIGINAL ARTICLES Phosphoproteins - metabolism Phosphorylation Promyelocytic leukemia protein Promyeloid leukemia Protein kinase C Protein Kinase C - metabolism Proteins Serine Signal transduction Signal Transduction - genetics SUMO protein SUMOylation TEAD TP73 Tumor suppressor genes Tumors YAP-Signaling Proteins YAP1 Yes-associated protein
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!