Nitrogen dioxide component of air pollution increases pulmonary congestion assessed by lung ultrasound in patients with chronic coronary syndromes
Pulmonary congestion is an intermediate biomarker and long-term predictor of acute decompensated heart failure. To evaluate the effects of air pollution on pulmonary congestion assessed by lung ultrasound. In a single-center, prospective, observational study design, we enrolled 1292 consecutive pati...
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| Veröffentlicht in: | Environmental science and pollution research international 2022-04, Vol.29 (18), p.26960-26968 |
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| creator | Ciampi, Quirino Russo, Antonello D’Alise, Caterina Ballirano, Anna Villari, Bruno Mangia, Cristina Picano, Eugenio |
| description | Pulmonary congestion is an intermediate biomarker and long-term predictor of acute decompensated heart failure.
To evaluate the effects of air pollution on pulmonary congestion assessed by lung ultrasound.
In a single-center, prospective, observational study design, we enrolled 1292 consecutive patients with chronic coronary syndromes referred for clinically indicated ABCDE-SE, with dipyridamole (
n
= 1207), dobutamine (
n
= 84), or treadmill exercise (
n
= 1). Pulmonary congestion was evaluated with lung ultrasound and a 4-site simplified scan. Same day values of 4 pollutants were obtained on the morning of testing (average of 6 h) from publicly available data sets of the regional authority of environmental protection. Assessment of air pollution included fine ( |
| doi_str_mv | 10.1007/s11356-021-17941-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8989823</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2661000123</sourcerecordid><originalsourceid>FETCH-LOGICAL-c507t-314c25367cb5095bed266311ca0b342aa3e674afe761a17078567f2d40e0c2583</originalsourceid><addsrcrecordid>eNqNUk1v1TAQtBCIPgp_gAOyxIVL6Dp27OSChCq-pKpc4Gw5jvOeq8QOdlJ4f6O_uPua0lIOCFmyDzsznt0dQl4yeMsA1ElmjFeygJIVTDUC70dkwyQThRJN85hsoBGiYFyII_Is5wuAEppSPSVHXNR1rXi1IVfnfk5x6wLtfPzlO0dtHKcYXJhp7KnxiU5xGJbZx0B9sMmZ7DKdlmGMwaQ9wsPW5ZuyyVjKrqPtng5L2NJlmJPJcQkdUulkZo-ymf70847aXYrBW-SnVSjvQ5fi6PJz8qQ3Q3Yvbt9j8v3jh2-nn4uzr5--nL4_K2wFai44E7asuFS2raCpWteVUnLGrIGWi9IY7qQSpndKMsMUqLqSqi87AQ6QWPNj8m7VnZZ2dJ1Fb8kMekp-RD86Gq8fVoLf6W281HWDp-Qo8OZWIMUfCw5Bjz5bNwwmuLhkjX5wT8D-Cwo19gLNAfr6L-hFXFLASSBKqKYCJg_myxVlU8w5uf7ONwN9SIde06ExHfomHZoh6dWfHd9RfscBAXwFZCzhXtP93_-QvQa6zMk_</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2647950168</pqid></control><display><type>article</type><title>Nitrogen dioxide component of air pollution increases pulmonary congestion assessed by lung ultrasound in patients with chronic coronary syndromes</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Ciampi, Quirino ; Russo, Antonello ; D’Alise, Caterina ; Ballirano, Anna ; Villari, Bruno ; Mangia, Cristina ; Picano, Eugenio</creator><creatorcontrib>Ciampi, Quirino ; Russo, Antonello ; D’Alise, Caterina ; Ballirano, Anna ; Villari, Bruno ; Mangia, Cristina ; Picano, Eugenio ; Stress Echo 2030 study group of the Italian Society of Echocardiography, Cardiovascular Imaging ; the Stress Echo 2030 study group of the Italian Society of Echocardiography, Cardiovascular Imaging</creatorcontrib><description>Pulmonary congestion is an intermediate biomarker and long-term predictor of acute decompensated heart failure.
To evaluate the effects of air pollution on pulmonary congestion assessed by lung ultrasound.
In a single-center, prospective, observational study design, we enrolled 1292 consecutive patients with chronic coronary syndromes referred for clinically indicated ABCDE-SE, with dipyridamole (
n
= 1207), dobutamine (
n
= 84), or treadmill exercise (
n
= 1). Pulmonary congestion was evaluated with lung ultrasound and a 4-site simplified scan. Same day values of 4 pollutants were obtained on the morning of testing (average of 6 h) from publicly available data sets of the regional authority of environmental protection. Assessment of air pollution included fine (< 2.5 µm diameter) and coarse (< 10 µm) particulate matter (PM), ozone and nitrogen dioxide (NO
2
).
NO
2
concentration was weakly correlated with rest (
r
= .089;
p
= 0.001) and peak stress B-lines (
r
= .099;
p
< 0.001). A multivariable logistic regression analysis, NO
2
values above the median (23.1 µg/m
3
) independently predicted stress B-lines with odds ratio = 1.480 (95% CI 1.118–1.958) together with age, hypertension, diabetes, and reduced (< 50%) ejection fraction. PM
2.5
values were higher in 249 patients with compared to those without B-lines (median and IQR, 22.0 [9.1–23.5] vs 17.6 [8.6–22.2] µg/m
3
,
p
< 0.001). No other pollutant correlated with other (A-C-D-E) SE steps.
Higher concentration of NO
2
is associated with more pulmonary congestion mirrored by B-lines at lung ultrasound. Local inflammation mediated by NO
2
well within legally allowed limits may increase the permeability of the alveolar-capillary barrier and therefore pulmonary congestion in susceptible subjects.
ClinicalTrials.gov Identifier: NCT030.49995.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-021-17941-1</identifier><identifier>PMID: 34888735</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Air Pollutants - analysis ; Air pollution ; Air Pollution - analysis ; Air pollution effects ; Alveoli ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Biomarkers ; Congestion ; Congestive heart failure ; diabetes ; Diabetes mellitus ; Dipyridamole ; Disorders ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Exposure - analysis ; Environmental Health ; Environmental protection ; Environmental science ; Evaluation ; exercise ; heart ; Humans ; Hypertension ; Lung - chemistry ; Lungs ; Median (statistics) ; Membrane permeability ; Nitrogen dioxide ; Nitrogen Dioxide - analysis ; Observational studies ; odds ratio ; ozone ; Particulate emissions ; Particulate matter ; Particulate Matter - analysis ; particulates ; Pollutants ; Prospective Studies ; Regression analysis ; Research Article ; Syndrome ; Treadmills ; Ultrasonic imaging ; ultrasonics ; Ultrasound ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2022-04, Vol.29 (18), p.26960-26968</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-314c25367cb5095bed266311ca0b342aa3e674afe761a17078567f2d40e0c2583</citedby><cites>FETCH-LOGICAL-c507t-314c25367cb5095bed266311ca0b342aa3e674afe761a17078567f2d40e0c2583</cites><orcidid>0000-0002-6375-6361</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-021-17941-1$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-021-17941-1$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34888735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ciampi, Quirino</creatorcontrib><creatorcontrib>Russo, Antonello</creatorcontrib><creatorcontrib>D’Alise, Caterina</creatorcontrib><creatorcontrib>Ballirano, Anna</creatorcontrib><creatorcontrib>Villari, Bruno</creatorcontrib><creatorcontrib>Mangia, Cristina</creatorcontrib><creatorcontrib>Picano, Eugenio</creatorcontrib><creatorcontrib>Stress Echo 2030 study group of the Italian Society of Echocardiography, Cardiovascular Imaging</creatorcontrib><creatorcontrib>the Stress Echo 2030 study group of the Italian Society of Echocardiography, Cardiovascular Imaging</creatorcontrib><title>Nitrogen dioxide component of air pollution increases pulmonary congestion assessed by lung ultrasound in patients with chronic coronary syndromes</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Pulmonary congestion is an intermediate biomarker and long-term predictor of acute decompensated heart failure.
To evaluate the effects of air pollution on pulmonary congestion assessed by lung ultrasound.
In a single-center, prospective, observational study design, we enrolled 1292 consecutive patients with chronic coronary syndromes referred for clinically indicated ABCDE-SE, with dipyridamole (
n
= 1207), dobutamine (
n
= 84), or treadmill exercise (
n
= 1). Pulmonary congestion was evaluated with lung ultrasound and a 4-site simplified scan. Same day values of 4 pollutants were obtained on the morning of testing (average of 6 h) from publicly available data sets of the regional authority of environmental protection. Assessment of air pollution included fine (< 2.5 µm diameter) and coarse (< 10 µm) particulate matter (PM), ozone and nitrogen dioxide (NO
2
).
NO
2
concentration was weakly correlated with rest (
r
= .089;
p
= 0.001) and peak stress B-lines (
r
= .099;
p
< 0.001). A multivariable logistic regression analysis, NO
2
values above the median (23.1 µg/m
3
) independently predicted stress B-lines with odds ratio = 1.480 (95% CI 1.118–1.958) together with age, hypertension, diabetes, and reduced (< 50%) ejection fraction. PM
2.5
values were higher in 249 patients with compared to those without B-lines (median and IQR, 22.0 [9.1–23.5] vs 17.6 [8.6–22.2] µg/m
3
,
p
< 0.001). No other pollutant correlated with other (A-C-D-E) SE steps.
Higher concentration of NO
2
is associated with more pulmonary congestion mirrored by B-lines at lung ultrasound. Local inflammation mediated by NO
2
well within legally allowed limits may increase the permeability of the alveolar-capillary barrier and therefore pulmonary congestion in susceptible subjects.
ClinicalTrials.gov Identifier: NCT030.49995.</description><subject>Air Pollutants - analysis</subject><subject>Air pollution</subject><subject>Air Pollution - analysis</subject><subject>Air pollution effects</subject><subject>Alveoli</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Biomarkers</subject><subject>Congestion</subject><subject>Congestive heart failure</subject><subject>diabetes</subject><subject>Diabetes mellitus</subject><subject>Dipyridamole</subject><subject>Disorders</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Exposure - analysis</subject><subject>Environmental Health</subject><subject>Environmental protection</subject><subject>Environmental science</subject><subject>Evaluation</subject><subject>exercise</subject><subject>heart</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Lung - chemistry</subject><subject>Lungs</subject><subject>Median (statistics)</subject><subject>Membrane permeability</subject><subject>Nitrogen dioxide</subject><subject>Nitrogen Dioxide - analysis</subject><subject>Observational studies</subject><subject>odds ratio</subject><subject>ozone</subject><subject>Particulate emissions</subject><subject>Particulate matter</subject><subject>Particulate Matter - analysis</subject><subject>particulates</subject><subject>Pollutants</subject><subject>Prospective Studies</subject><subject>Regression analysis</subject><subject>Research Article</subject><subject>Syndrome</subject><subject>Treadmills</subject><subject>Ultrasonic imaging</subject><subject>ultrasonics</subject><subject>Ultrasound</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNUk1v1TAQtBCIPgp_gAOyxIVL6Dp27OSChCq-pKpc4Gw5jvOeq8QOdlJ4f6O_uPua0lIOCFmyDzsznt0dQl4yeMsA1ElmjFeygJIVTDUC70dkwyQThRJN85hsoBGiYFyII_Is5wuAEppSPSVHXNR1rXi1IVfnfk5x6wLtfPzlO0dtHKcYXJhp7KnxiU5xGJbZx0B9sMmZ7DKdlmGMwaQ9wsPW5ZuyyVjKrqPtng5L2NJlmJPJcQkdUulkZo-ymf70847aXYrBW-SnVSjvQ5fi6PJz8qQ3Q3Yvbt9j8v3jh2-nn4uzr5--nL4_K2wFai44E7asuFS2raCpWteVUnLGrIGWi9IY7qQSpndKMsMUqLqSqi87AQ6QWPNj8m7VnZZ2dJ1Fb8kMekp-RD86Gq8fVoLf6W281HWDp-Qo8OZWIMUfCw5Bjz5bNwwmuLhkjX5wT8D-Cwo19gLNAfr6L-hFXFLASSBKqKYCJg_myxVlU8w5uf7ONwN9SIde06ExHfomHZoh6dWfHd9RfscBAXwFZCzhXtP93_-QvQa6zMk_</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Ciampi, Quirino</creator><creator>Russo, Antonello</creator><creator>D’Alise, Caterina</creator><creator>Ballirano, Anna</creator><creator>Villari, Bruno</creator><creator>Mangia, Cristina</creator><creator>Picano, Eugenio</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6375-6361</orcidid></search><sort><creationdate>20220401</creationdate><title>Nitrogen dioxide component of air pollution increases pulmonary congestion assessed by lung ultrasound in patients with chronic coronary syndromes</title><author>Ciampi, Quirino ; Russo, Antonello ; D’Alise, Caterina ; Ballirano, Anna ; Villari, Bruno ; Mangia, Cristina ; Picano, Eugenio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-314c25367cb5095bed266311ca0b342aa3e674afe761a17078567f2d40e0c2583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Air Pollutants - analysis</topic><topic>Air pollution</topic><topic>Air Pollution - analysis</topic><topic>Air pollution effects</topic><topic>Alveoli</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Biomarkers</topic><topic>Congestion</topic><topic>Congestive heart failure</topic><topic>diabetes</topic><topic>Diabetes mellitus</topic><topic>Dipyridamole</topic><topic>Disorders</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Exposure - analysis</topic><topic>Environmental Health</topic><topic>Environmental protection</topic><topic>Environmental science</topic><topic>Evaluation</topic><topic>exercise</topic><topic>heart</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Lung - chemistry</topic><topic>Lungs</topic><topic>Median (statistics)</topic><topic>Membrane permeability</topic><topic>Nitrogen dioxide</topic><topic>Nitrogen Dioxide - analysis</topic><topic>Observational studies</topic><topic>odds ratio</topic><topic>ozone</topic><topic>Particulate emissions</topic><topic>Particulate matter</topic><topic>Particulate Matter - analysis</topic><topic>particulates</topic><topic>Pollutants</topic><topic>Prospective Studies</topic><topic>Regression analysis</topic><topic>Research Article</topic><topic>Syndrome</topic><topic>Treadmills</topic><topic>Ultrasonic imaging</topic><topic>ultrasonics</topic><topic>Ultrasound</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollution Control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ciampi, Quirino</creatorcontrib><creatorcontrib>Russo, Antonello</creatorcontrib><creatorcontrib>D’Alise, Caterina</creatorcontrib><creatorcontrib>Ballirano, Anna</creatorcontrib><creatorcontrib>Villari, Bruno</creatorcontrib><creatorcontrib>Mangia, Cristina</creatorcontrib><creatorcontrib>Picano, Eugenio</creatorcontrib><creatorcontrib>Stress Echo 2030 study group of the Italian Society of Echocardiography, Cardiovascular Imaging</creatorcontrib><creatorcontrib>the Stress Echo 2030 study group of the Italian Society of Echocardiography, Cardiovascular Imaging</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ecology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ciampi, Quirino</au><au>Russo, Antonello</au><au>D’Alise, Caterina</au><au>Ballirano, Anna</au><au>Villari, Bruno</au><au>Mangia, Cristina</au><au>Picano, Eugenio</au><aucorp>Stress Echo 2030 study group of the Italian Society of Echocardiography, Cardiovascular Imaging</aucorp><aucorp>the Stress Echo 2030 study group of the Italian Society of Echocardiography, Cardiovascular Imaging</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nitrogen dioxide component of air pollution increases pulmonary congestion assessed by lung ultrasound in patients with chronic coronary syndromes</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>29</volume><issue>18</issue><spage>26960</spage><epage>26968</epage><pages>26960-26968</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Pulmonary congestion is an intermediate biomarker and long-term predictor of acute decompensated heart failure.
To evaluate the effects of air pollution on pulmonary congestion assessed by lung ultrasound.
In a single-center, prospective, observational study design, we enrolled 1292 consecutive patients with chronic coronary syndromes referred for clinically indicated ABCDE-SE, with dipyridamole (
n
= 1207), dobutamine (
n
= 84), or treadmill exercise (
n
= 1). Pulmonary congestion was evaluated with lung ultrasound and a 4-site simplified scan. Same day values of 4 pollutants were obtained on the morning of testing (average of 6 h) from publicly available data sets of the regional authority of environmental protection. Assessment of air pollution included fine (< 2.5 µm diameter) and coarse (< 10 µm) particulate matter (PM), ozone and nitrogen dioxide (NO
2
).
NO
2
concentration was weakly correlated with rest (
r
= .089;
p
= 0.001) and peak stress B-lines (
r
= .099;
p
< 0.001). A multivariable logistic regression analysis, NO
2
values above the median (23.1 µg/m
3
) independently predicted stress B-lines with odds ratio = 1.480 (95% CI 1.118–1.958) together with age, hypertension, diabetes, and reduced (< 50%) ejection fraction. PM
2.5
values were higher in 249 patients with compared to those without B-lines (median and IQR, 22.0 [9.1–23.5] vs 17.6 [8.6–22.2] µg/m
3
,
p
< 0.001). No other pollutant correlated with other (A-C-D-E) SE steps.
Higher concentration of NO
2
is associated with more pulmonary congestion mirrored by B-lines at lung ultrasound. Local inflammation mediated by NO
2
well within legally allowed limits may increase the permeability of the alveolar-capillary barrier and therefore pulmonary congestion in susceptible subjects.
ClinicalTrials.gov Identifier: NCT030.49995.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34888735</pmid><doi>10.1007/s11356-021-17941-1</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6375-6361</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1344 |
| ispartof | Environmental science and pollution research international, 2022-04, Vol.29 (18), p.26960-26968 |
| issn | 0944-1344 1614-7499 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8989823 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Air Pollutants - analysis Air pollution Air Pollution - analysis Air pollution effects Alveoli Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Biomarkers Congestion Congestive heart failure diabetes Diabetes mellitus Dipyridamole Disorders Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Exposure - analysis Environmental Health Environmental protection Environmental science Evaluation exercise heart Humans Hypertension Lung - chemistry Lungs Median (statistics) Membrane permeability Nitrogen dioxide Nitrogen Dioxide - analysis Observational studies odds ratio ozone Particulate emissions Particulate matter Particulate Matter - analysis particulates Pollutants Prospective Studies Regression analysis Research Article Syndrome Treadmills Ultrasonic imaging ultrasonics Ultrasound Waste Water Technology Water Management Water Pollution Control |
| title | Nitrogen dioxide component of air pollution increases pulmonary congestion assessed by lung ultrasound in patients with chronic coronary syndromes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T10%3A43%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nitrogen%20dioxide%20component%20of%20air%20pollution%20increases%20pulmonary%20congestion%20assessed%20by%20lung%20ultrasound%20in%20patients%20with%20chronic%20coronary%20syndromes&rft.jtitle=Environmental%20science%20and%20pollution%20research%20international&rft.au=Ciampi,%20Quirino&rft.aucorp=Stress%20Echo%202030%20study%20group%20of%20the%20Italian%20Society%20of%20Echocardiography,%20Cardiovascular%20Imaging&rft.date=2022-04-01&rft.volume=29&rft.issue=18&rft.spage=26960&rft.epage=26968&rft.pages=26960-26968&rft.issn=0944-1344&rft.eissn=1614-7499&rft_id=info:doi/10.1007/s11356-021-17941-1&rft_dat=%3Cproquest_pubme%3E2661000123%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2647950168&rft_id=info:pmid/34888735&rfr_iscdi=true |