Combination of Two Synchrotron Radiation-Based Techniques and Chemometrics to Study an Enhanced Natural Remineralization of Enamel
The limitations to assess dental enamel remineralization have been overcome by a methodology resulting from the appropriate combination of synchrotron radiation-based techniques on both, infrared microspectroscopy and micro X-ray diffraction, with the help of specific data mining. Since amelogenin p...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2022-04, Vol.94 (13), p.5359-5366 |
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| creator | Diez-García, Sandra Sánchez-Martín, María-Jesús Amigo, José Manuel Valiente, Manuel |
| description | The limitations to assess dental enamel remineralization have been overcome by a methodology resulting from the appropriate combination of synchrotron radiation-based techniques on both, infrared microspectroscopy and micro X-ray diffraction, with the help of specific data mining. Since amelogenin plays a key role in modulating the mineralization of tooth enamel, we propose a controlled ion release for fluorapatite structural ions (Ca2+, PO4 3–, and F–, also including Zn2+) by using weak acid and weak base ion-exchange resins in the presence of amelogenin to remineralize the surface of etched teeth. This combination provides the necessary ions for enamel remineralization and a guide for crystal growth due to the protein. Remineralized tooth samples were analyzed by applying the indicated methodology. The synchrotron data were treated using principal component analysis and multivariate curve resolution to analyze the mineral layer formed in the presence and absence of amelogenin. The remineralizing treatment created a fluorapatite layer free of carbonate impurities and with a similar orientation to that of the natural enamel thanks to amelogenin contribution. |
| doi_str_mv | 10.1021/acs.analchem.1c05498 |
| format | Article |
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Since amelogenin plays a key role in modulating the mineralization of tooth enamel, we propose a controlled ion release for fluorapatite structural ions (Ca2+, PO4 3–, and F–, also including Zn2+) by using weak acid and weak base ion-exchange resins in the presence of amelogenin to remineralize the surface of etched teeth. This combination provides the necessary ions for enamel remineralization and a guide for crystal growth due to the protein. Remineralized tooth samples were analyzed by applying the indicated methodology. The synchrotron data were treated using principal component analysis and multivariate curve resolution to analyze the mineral layer formed in the presence and absence of amelogenin. The remineralizing treatment created a fluorapatite layer free of carbonate impurities and with a similar orientation to that of the natural enamel thanks to amelogenin contribution.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/acs.analchem.1c05498</identifier><identifier>PMID: 35319204</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Amelogenin ; Analytical chemistry ; Calcium ions ; Chemistry ; Chemometrics ; Crystal growth ; Data mining ; Dental Enamel ; Dental restorative materials ; Enamel ; Fluorapatite ; Impurities ; Ion exchange ; Ion exchange resins ; Ions ; Mineralization ; Principal components analysis ; Radiation ; Remineralization ; Resins ; Synchrotron radiation ; Synchrotrons ; Teeth ; Tooth Remineralization ; X-Ray Diffraction ; Zinc</subject><ispartof>Analytical chemistry (Washington), 2022-04, Vol.94 (13), p.5359-5366</ispartof><rights>2022 The Authors. Published by American Chemical Society</rights><rights>Copyright American Chemical Society Apr 5, 2022</rights><rights>2022 The Authors. Published by American Chemical Society 2022 The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a3928-3ab222919e9e5b840c40335cc6bb430f847b038063be2402dc7527b7a07632e83</citedby><cites>FETCH-LOGICAL-a3928-3ab222919e9e5b840c40335cc6bb430f847b038063be2402dc7527b7a07632e83</cites><orcidid>0000-0003-1678-6055</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.analchem.1c05498$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.analchem.1c05498$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,314,776,780,881,2751,27055,27903,27904,56717,56767</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35319204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diez-García, Sandra</creatorcontrib><creatorcontrib>Sánchez-Martín, María-Jesús</creatorcontrib><creatorcontrib>Amigo, José Manuel</creatorcontrib><creatorcontrib>Valiente, Manuel</creatorcontrib><title>Combination of Two Synchrotron Radiation-Based Techniques and Chemometrics to Study an Enhanced Natural Remineralization of Enamel</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>The limitations to assess dental enamel remineralization have been overcome by a methodology resulting from the appropriate combination of synchrotron radiation-based techniques on both, infrared microspectroscopy and micro X-ray diffraction, with the help of specific data mining. Since amelogenin plays a key role in modulating the mineralization of tooth enamel, we propose a controlled ion release for fluorapatite structural ions (Ca2+, PO4 3–, and F–, also including Zn2+) by using weak acid and weak base ion-exchange resins in the presence of amelogenin to remineralize the surface of etched teeth. This combination provides the necessary ions for enamel remineralization and a guide for crystal growth due to the protein. Remineralized tooth samples were analyzed by applying the indicated methodology. The synchrotron data were treated using principal component analysis and multivariate curve resolution to analyze the mineral layer formed in the presence and absence of amelogenin. The remineralizing treatment created a fluorapatite layer free of carbonate impurities and with a similar orientation to that of the natural enamel thanks to amelogenin contribution.</description><subject>Amelogenin</subject><subject>Analytical chemistry</subject><subject>Calcium ions</subject><subject>Chemistry</subject><subject>Chemometrics</subject><subject>Crystal growth</subject><subject>Data mining</subject><subject>Dental Enamel</subject><subject>Dental restorative materials</subject><subject>Enamel</subject><subject>Fluorapatite</subject><subject>Impurities</subject><subject>Ion exchange</subject><subject>Ion exchange resins</subject><subject>Ions</subject><subject>Mineralization</subject><subject>Principal components analysis</subject><subject>Radiation</subject><subject>Remineralization</subject><subject>Resins</subject><subject>Synchrotron radiation</subject><subject>Synchrotrons</subject><subject>Teeth</subject><subject>Tooth Remineralization</subject><subject>X-Ray Diffraction</subject><subject>Zinc</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcuO0zAUtRCI6Qz8AUKW2LBJuX4kcTZIUHUAaQTSUNbWjeMSjxJ7sBNQWfLluNNOBSxY2fJ53etDyDMGSwacvUKTluhxML0dl8xAKRv1gCxYyaGolOIPyQIARMFrgDNyntINAGPAqsfkTJSCNRzkgvxahbF1HicXPA1buvkR6OedN30MU8xP19i5O7B4i8l2dGNN79232SaKvqOrHB5GO0VnEp2ydJq7XUbo2vfoTRZ8xGmOONBrOzpv8839PIWtPY52eEIebXFI9unxvCBfLteb1fvi6tO7D6s3VwWKhqtCYMs5b1hjG1u2SoKRIERpTNW2UsBWyboFoaASreUSeGfqktdtjVBXglslLsjrg-_t3I62M9ZPeRx9G92IcacDOv034l2vv4bvWjVKMc6zwcujQQz7H5j06JKxw4DehjlpXkkueE4TmfriH-pNmGNu647V1BUItjeUB5aJIaVot6dhGOh9yTqXrO9L1seSs-z5n4ucRPetZgIcCHv5Kfi_nr8BPGq35w</recordid><startdate>20220405</startdate><enddate>20220405</enddate><creator>Diez-García, Sandra</creator><creator>Sánchez-Martín, María-Jesús</creator><creator>Amigo, José Manuel</creator><creator>Valiente, Manuel</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1678-6055</orcidid></search><sort><creationdate>20220405</creationdate><title>Combination of Two Synchrotron Radiation-Based Techniques and Chemometrics to Study an Enhanced Natural Remineralization of Enamel</title><author>Diez-García, Sandra ; Sánchez-Martín, María-Jesús ; Amigo, José Manuel ; Valiente, Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a3928-3ab222919e9e5b840c40335cc6bb430f847b038063be2402dc7527b7a07632e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Amelogenin</topic><topic>Analytical chemistry</topic><topic>Calcium ions</topic><topic>Chemistry</topic><topic>Chemometrics</topic><topic>Crystal growth</topic><topic>Data mining</topic><topic>Dental Enamel</topic><topic>Dental restorative materials</topic><topic>Enamel</topic><topic>Fluorapatite</topic><topic>Impurities</topic><topic>Ion exchange</topic><topic>Ion exchange resins</topic><topic>Ions</topic><topic>Mineralization</topic><topic>Principal components analysis</topic><topic>Radiation</topic><topic>Remineralization</topic><topic>Resins</topic><topic>Synchrotron radiation</topic><topic>Synchrotrons</topic><topic>Teeth</topic><topic>Tooth Remineralization</topic><topic>X-Ray Diffraction</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diez-García, Sandra</creatorcontrib><creatorcontrib>Sánchez-Martín, María-Jesús</creatorcontrib><creatorcontrib>Amigo, José Manuel</creatorcontrib><creatorcontrib>Valiente, Manuel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diez-García, Sandra</au><au>Sánchez-Martín, María-Jesús</au><au>Amigo, José Manuel</au><au>Valiente, Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combination of Two Synchrotron Radiation-Based Techniques and Chemometrics to Study an Enhanced Natural Remineralization of Enamel</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2022-04-05</date><risdate>2022</risdate><volume>94</volume><issue>13</issue><spage>5359</spage><epage>5366</epage><pages>5359-5366</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><abstract>The limitations to assess dental enamel remineralization have been overcome by a methodology resulting from the appropriate combination of synchrotron radiation-based techniques on both, infrared microspectroscopy and micro X-ray diffraction, with the help of specific data mining. Since amelogenin plays a key role in modulating the mineralization of tooth enamel, we propose a controlled ion release for fluorapatite structural ions (Ca2+, PO4 3–, and F–, also including Zn2+) by using weak acid and weak base ion-exchange resins in the presence of amelogenin to remineralize the surface of etched teeth. This combination provides the necessary ions for enamel remineralization and a guide for crystal growth due to the protein. Remineralized tooth samples were analyzed by applying the indicated methodology. The synchrotron data were treated using principal component analysis and multivariate curve resolution to analyze the mineral layer formed in the presence and absence of amelogenin. The remineralizing treatment created a fluorapatite layer free of carbonate impurities and with a similar orientation to that of the natural enamel thanks to amelogenin contribution.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>35319204</pmid><doi>10.1021/acs.analchem.1c05498</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1678-6055</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Amelogenin Analytical chemistry Calcium ions Chemistry Chemometrics Crystal growth Data mining Dental Enamel Dental restorative materials Enamel Fluorapatite Impurities Ion exchange Ion exchange resins Ions Mineralization Principal components analysis Radiation Remineralization Resins Synchrotron radiation Synchrotrons Teeth Tooth Remineralization X-Ray Diffraction Zinc |
| title | Combination of Two Synchrotron Radiation-Based Techniques and Chemometrics to Study an Enhanced Natural Remineralization of Enamel |
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