Massive Polycystic Liver with a Poor Performance Status Successfully Treated by ABO-incompatible Adult Living-donor Liver Transplantation While Overcoming Complications
We encountered a 47-year-old woman with polycystic liver disease (PLD) and severe malnutrition successfully treated by living-donor liver transplantation (LDLT). Her PLD became symptomatic with abdominal distension and appetite loss. Transcatheter arterial embolization and percutaneous cyst drainage...
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| Veröffentlicht in: | Internal Medicine 2022/03/15, Vol.61(6), pp.841-849 |
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| container_title | Internal Medicine |
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| creator | Takakusagi, Satoshi Masuda, Yuichi Takagi, Hitoshi Yokoyama, Yozo Kizawa, Kazuko Marubashi, Kyoko Kosone, Takashi Soejima, Yuji |
| description | We encountered a 47-year-old woman with polycystic liver disease (PLD) and severe malnutrition successfully treated by living-donor liver transplantation (LDLT). Her PLD became symptomatic with abdominal distension and appetite loss. Transcatheter arterial embolization and percutaneous cyst drainage failed to improve her symptoms. ABO-incompatible LDLT from her husband was performed after rituximab administration and mycophenolate mofetil introduction. Although she showed severe postoperative complications, she ultimately regained the ability to walk and was discharged. Because advanced PLD cases are difficult to treat conservatively or with surgery, like fenestration and hepatectomy, liver transplantation should be considered before it becomes too late. |
| doi_str_mv | 10.2169/internalmedicine.8290-21 |
| format | Article |
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Her PLD became symptomatic with abdominal distension and appetite loss. Transcatheter arterial embolization and percutaneous cyst drainage failed to improve her symptoms. ABO-incompatible LDLT from her husband was performed after rituximab administration and mycophenolate mofetil introduction. Although she showed severe postoperative complications, she ultimately regained the ability to walk and was discharged. Because advanced PLD cases are difficult to treat conservatively or with surgery, like fenestration and hepatectomy, liver transplantation should be considered before it becomes too late.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.8290-21</identifier><identifier>PMID: 34483217</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>ABO Blood-Group System ; ABO system ; ABO-incompatible ; Adult ; Appetite loss ; Blood Group Incompatibility - complications ; Blood groups ; Case Report ; Complications ; Distension ; Embolization ; Female ; Hepatectomy ; hepatomegaly ; Humans ; Internal medicine ; Liver ; Liver diseases ; Liver Transplantation ; Living Donors ; living-donor liver transplantation ; Malnutrition ; Middle Aged ; Mycophenolate mofetil ; Mycophenolic acid ; polycystic liver disease ; Postoperative ; Rituximab</subject><ispartof>Internal Medicine, 2022/03/15, Vol.61(6), pp.841-849</ispartof><rights>2022 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2022</rights><rights>Copyright © 2022 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c609t-2d1612aaf86982e415976b831b01dd7f261bd5856be5b2802e22d99dcc938aa13</citedby><cites>FETCH-LOGICAL-c609t-2d1612aaf86982e415976b831b01dd7f261bd5856be5b2802e22d99dcc938aa13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987261/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987261/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34483217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takakusagi, Satoshi</creatorcontrib><creatorcontrib>Masuda, Yuichi</creatorcontrib><creatorcontrib>Takagi, Hitoshi</creatorcontrib><creatorcontrib>Yokoyama, Yozo</creatorcontrib><creatorcontrib>Kizawa, Kazuko</creatorcontrib><creatorcontrib>Marubashi, Kyoko</creatorcontrib><creatorcontrib>Kosone, Takashi</creatorcontrib><creatorcontrib>Soejima, Yuji</creatorcontrib><title>Massive Polycystic Liver with a Poor Performance Status Successfully Treated by ABO-incompatible Adult Living-donor Liver Transplantation While Overcoming Complications</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>We encountered a 47-year-old woman with polycystic liver disease (PLD) and severe malnutrition successfully treated by living-donor liver transplantation (LDLT). Her PLD became symptomatic with abdominal distension and appetite loss. Transcatheter arterial embolization and percutaneous cyst drainage failed to improve her symptoms. ABO-incompatible LDLT from her husband was performed after rituximab administration and mycophenolate mofetil introduction. Although she showed severe postoperative complications, she ultimately regained the ability to walk and was discharged. Because advanced PLD cases are difficult to treat conservatively or with surgery, like fenestration and hepatectomy, liver transplantation should be considered before it becomes too late.</description><subject>ABO Blood-Group System</subject><subject>ABO system</subject><subject>ABO-incompatible</subject><subject>Adult</subject><subject>Appetite loss</subject><subject>Blood Group Incompatibility - complications</subject><subject>Blood groups</subject><subject>Case Report</subject><subject>Complications</subject><subject>Distension</subject><subject>Embolization</subject><subject>Female</subject><subject>Hepatectomy</subject><subject>hepatomegaly</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Liver Transplantation</subject><subject>Living Donors</subject><subject>living-donor liver transplantation</subject><subject>Malnutrition</subject><subject>Middle Aged</subject><subject>Mycophenolate mofetil</subject><subject>Mycophenolic acid</subject><subject>polycystic liver disease</subject><subject>Postoperative</subject><subject>Rituximab</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkt2OEyEUgCdG49bVVzAk3ngzKzAzDNyY1GZdTardZGu8JAxzpqWhUIFZ0zfax5Ta2uh6A4Hzne_wc4oCEXxFCRPvjEsQnLJb6I02Dq44Fbik5EkxIVUtypZWzdNiggXhJc3DRfEixg3GFW8FfV5cVHXNK0raSfHwRcVo7gHdervX-5iMRvO8DuinSWuk8r4P6BbC4MNWOQ3oLqk0RnQ3ag0xDqO1e7QMoBL0qNuj6YdFaZz2251KprOApv1o08Fp3Krsvcu6Y4FlUC7urHJZaLxD39cm44scytkZRrMssUb_jsaXxbNB2QivTvNl8e3j9XL2qZwvbj7PpvNSMyxSSXvCCFVq4ExwCjVpRMs6XpEOk75vB8pI1ze8YR00HeWYAqW9EL3WouJKkeqyeH_07sYuP68Gl4KychfMVoW99MrIfyPOrOXK30sueJvtWfD2JAj-xwgxya2JGmy-KPgxStowwUiLmzajbx6hGz8e_jVTrGakqWuCM8WPlA4-xgDD-TAEy0M7yMftIA_tkEM59fXflzkn_vn_DHw9ApuY1ArOgAq5ESz8b2ZEssNwqnAG9VoFCa76Be9Q2Ck</recordid><startdate>20220315</startdate><enddate>20220315</enddate><creator>Takakusagi, Satoshi</creator><creator>Masuda, Yuichi</creator><creator>Takagi, Hitoshi</creator><creator>Yokoyama, Yozo</creator><creator>Kizawa, Kazuko</creator><creator>Marubashi, Kyoko</creator><creator>Kosone, Takashi</creator><creator>Soejima, Yuji</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220315</creationdate><title>Massive Polycystic Liver with a Poor Performance Status Successfully Treated by ABO-incompatible Adult Living-donor Liver Transplantation While Overcoming Complications</title><author>Takakusagi, Satoshi ; Masuda, Yuichi ; Takagi, Hitoshi ; Yokoyama, Yozo ; Kizawa, Kazuko ; Marubashi, Kyoko ; Kosone, Takashi ; Soejima, Yuji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c609t-2d1612aaf86982e415976b831b01dd7f261bd5856be5b2802e22d99dcc938aa13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>ABO Blood-Group System</topic><topic>ABO system</topic><topic>ABO-incompatible</topic><topic>Adult</topic><topic>Appetite loss</topic><topic>Blood Group Incompatibility - complications</topic><topic>Blood groups</topic><topic>Case Report</topic><topic>Complications</topic><topic>Distension</topic><topic>Embolization</topic><topic>Female</topic><topic>Hepatectomy</topic><topic>hepatomegaly</topic><topic>Humans</topic><topic>Internal medicine</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>Liver Transplantation</topic><topic>Living Donors</topic><topic>living-donor liver transplantation</topic><topic>Malnutrition</topic><topic>Middle Aged</topic><topic>Mycophenolate mofetil</topic><topic>Mycophenolic acid</topic><topic>polycystic liver disease</topic><topic>Postoperative</topic><topic>Rituximab</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takakusagi, Satoshi</creatorcontrib><creatorcontrib>Masuda, Yuichi</creatorcontrib><creatorcontrib>Takagi, Hitoshi</creatorcontrib><creatorcontrib>Yokoyama, Yozo</creatorcontrib><creatorcontrib>Kizawa, Kazuko</creatorcontrib><creatorcontrib>Marubashi, Kyoko</creatorcontrib><creatorcontrib>Kosone, Takashi</creatorcontrib><creatorcontrib>Soejima, Yuji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takakusagi, Satoshi</au><au>Masuda, Yuichi</au><au>Takagi, Hitoshi</au><au>Yokoyama, Yozo</au><au>Kizawa, Kazuko</au><au>Marubashi, Kyoko</au><au>Kosone, Takashi</au><au>Soejima, Yuji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Massive Polycystic Liver with a Poor Performance Status Successfully Treated by ABO-incompatible Adult Living-donor Liver Transplantation While Overcoming Complications</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2022-03-15</date><risdate>2022</risdate><volume>61</volume><issue>6</issue><spage>841</spage><epage>849</epage><pages>841-849</pages><artnum>8290-21</artnum><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>We encountered a 47-year-old woman with polycystic liver disease (PLD) and severe malnutrition successfully treated by living-donor liver transplantation (LDLT). Her PLD became symptomatic with abdominal distension and appetite loss. Transcatheter arterial embolization and percutaneous cyst drainage failed to improve her symptoms. ABO-incompatible LDLT from her husband was performed after rituximab administration and mycophenolate mofetil introduction. Although she showed severe postoperative complications, she ultimately regained the ability to walk and was discharged. 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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; PubMed Central; PubMed Central Open Access |
| subjects | ABO Blood-Group System ABO system ABO-incompatible Adult Appetite loss Blood Group Incompatibility - complications Blood groups Case Report Complications Distension Embolization Female Hepatectomy hepatomegaly Humans Internal medicine Liver Liver diseases Liver Transplantation Living Donors living-donor liver transplantation Malnutrition Middle Aged Mycophenolate mofetil Mycophenolic acid polycystic liver disease Postoperative Rituximab |
| title | Massive Polycystic Liver with a Poor Performance Status Successfully Treated by ABO-incompatible Adult Living-donor Liver Transplantation While Overcoming Complications |
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