Dimethyl sulfoxide stimulates the AhR-Jdp2 axis to control ROS accumulation in mouse embryonic fibroblasts

The aryl hydrocarbon receptor (AhR) is a ligand-binding protein that responds to environmental aromatic hydrocarbons and stimulates the transcription of downstream phase I enzyme–related genes by binding the cis element of dioxin-responsive elements (DREs)/xenobiotic-responsive elements. Dimethyl su...

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Veröffentlicht in:	Cell biology and toxicology 2022-04, Vol.38 (2), p.203-222
Hauptverfasser:	Wuputra, Kenly, Tsai, Ming-Ho, Kato, Kohsuke, Yang, Ya-han, Pan, Jia-Bin, Ku, Chia-Chen, Noguchi, Michiya, Kishikawa, Shotaro, Nakade, Koji, Chen, Hua-Ling, Liu, Chung-Jung, Nakamura, Yukio, Kuo, Kung-Kai, Lin, Ying-Chu, Chan, Te-Fu, Wu, Deng-Chyang, Hou, Ming-Feng, Huang, Shau-Ku, Lin, Chang-Shen, Yokoyama, Kazunari K.
Format:	Artikel
Sprache:	eng
Schlagworte:	AhR gene Animals Apoptosis Aromatic hydrocarbons Biochemistry Biomedical and Life Sciences Cell Biology Cell spreading Chromatin Dimerization Dimethyl sulfoxide Dimethyl Sulfoxide - pharmacology Dioxins Embryo fibroblasts Fibroblasts Fibroblasts - metabolism Hydrocarbons Immunoprecipitation Life Sciences Ligands Mice NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism NRF2 protein Original Original Article Oxidative stress Pharmacology/Toxicology Polychlorinated Dibenzodioxins - pharmacology Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Reagents Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism Sulfoxides Toxicology Transcription factors
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