The Role of Single Nucleotide Polymorphisms of Monoamine Oxidase B, Dopamine D2 Receptor, and DOPA Decarboxylase Receptors Among Patients Treated for Parkinson’s Disease
This study aimed to investigate the association between selected variants of genes related to dopamine metabolism pathways and the risk of and progression of Parkinson’s disease (PD). This prospective cohort study was conducted in one academic teaching hospital. The study was conducted on 126 patien...
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| Veröffentlicht in: | Journal of molecular neuroscience 2022-04, Vol.72 (4), p.812-819 |
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| container_title | Journal of molecular neuroscience |
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| creator | Zapała, Barbara Stefura, Tomasz Piwowar, Monika Czekalska, Sylwia Zawada, Magdalena Hadasik, Maria Solnica, Bogdan Rudzińska-Bar, Monika |
| description | This study aimed to investigate the association between selected variants of genes related to dopamine metabolism pathways and the risk of and progression of Parkinson’s disease (PD). This prospective cohort study was conducted in one academic teaching hospital. The study was conducted on 126 patients diagnosed with idiopathic Parkinson’s disease. Blood samples were collected to conduct a genotyping of MAOB, DRD1, DRD2, and DDC genes. Genotype and allele frequencies of MAOB (rs1799836) variants were not associated with the course of PD. Genotype and allele frequencies of DRD2 (rs2283265) variants were associated with risk of dementia (
p
= 0.001) and resulted in parts II and III of the UPDRS scale (
p
= 0.001). Genotype and allele frequencies of DRD2 (rs1076560) variants were associated with risk of dementia (
p
= 0.001) and resulted in parts II and III of the UPDRS scale (
p
= 0.001). Genotype and allele frequencies of DDC (rs921451) variants were not associated with the course of PD. |
| doi_str_mv | 10.1007/s12031-022-01966-3 |
| format | Article |
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p
= 0.001) and resulted in parts II and III of the UPDRS scale (
p
= 0.001). Genotype and allele frequencies of DRD2 (rs1076560) variants were associated with risk of dementia (
p
= 0.001) and resulted in parts II and III of the UPDRS scale (
p
= 0.001). Genotype and allele frequencies of DDC (rs921451) variants were not associated with the course of PD.</description><identifier>ISSN: 0895-8696</identifier><identifier>EISSN: 1559-1166</identifier><identifier>DOI: 10.1007/s12031-022-01966-3</identifier><identifier>PMID: 35044623</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alleles ; Amine oxidase (flavin-containing) ; Aromatic-L-amino-acid decarboxylase ; Biomedical and Life Sciences ; Biomedicine ; Carrier Proteins - genetics ; Cell Biology ; Dementia ; Dementia disorders ; Dihydroxyphenylalanine ; Dopa Decarboxylase - genetics ; Dopamine ; Dopamine D1 receptors ; Dopamine D2 receptors ; Gene frequency ; Genes ; Genotype ; Genotype & phenotype ; Genotyping ; Humans ; Metabolism ; Monoamine Oxidase - genetics ; Movement disorders ; Neurochemistry ; Neurodegenerative diseases ; Neurology ; Neurosciences ; Nucleotides ; Parkinson Disease - genetics ; Parkinson's disease ; Patients ; Polymorphism, Single Nucleotide ; Prospective Studies ; Proteomics ; Receptors ; Receptors, Dopamine D2 - genetics ; Risk ; Single-nucleotide polymorphism</subject><ispartof>Journal of molecular neuroscience, 2022-04, Vol.72 (4), p.812-819</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-9e7afd156f5ba7862a6cfc05a843ae5078128547870ea0e776799e359b1a2cfa3</citedby><cites>FETCH-LOGICAL-c540t-9e7afd156f5ba7862a6cfc05a843ae5078128547870ea0e776799e359b1a2cfa3</cites><orcidid>0000-0002-2553-272X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12031-022-01966-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12031-022-01966-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35044623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zapała, Barbara</creatorcontrib><creatorcontrib>Stefura, Tomasz</creatorcontrib><creatorcontrib>Piwowar, Monika</creatorcontrib><creatorcontrib>Czekalska, Sylwia</creatorcontrib><creatorcontrib>Zawada, Magdalena</creatorcontrib><creatorcontrib>Hadasik, Maria</creatorcontrib><creatorcontrib>Solnica, Bogdan</creatorcontrib><creatorcontrib>Rudzińska-Bar, Monika</creatorcontrib><title>The Role of Single Nucleotide Polymorphisms of Monoamine Oxidase B, Dopamine D2 Receptor, and DOPA Decarboxylase Receptors Among Patients Treated for Parkinson’s Disease</title><title>Journal of molecular neuroscience</title><addtitle>J Mol Neurosci</addtitle><addtitle>J Mol Neurosci</addtitle><description>This study aimed to investigate the association between selected variants of genes related to dopamine metabolism pathways and the risk of and progression of Parkinson’s disease (PD). This prospective cohort study was conducted in one academic teaching hospital. The study was conducted on 126 patients diagnosed with idiopathic Parkinson’s disease. Blood samples were collected to conduct a genotyping of MAOB, DRD1, DRD2, and DDC genes. Genotype and allele frequencies of MAOB (rs1799836) variants were not associated with the course of PD. Genotype and allele frequencies of DRD2 (rs2283265) variants were associated with risk of dementia (
p
= 0.001) and resulted in parts II and III of the UPDRS scale (
p
= 0.001). Genotype and allele frequencies of DRD2 (rs1076560) variants were associated with risk of dementia (
p
= 0.001) and resulted in parts II and III of the UPDRS scale (
p
= 0.001). Genotype and allele frequencies of DDC (rs921451) variants were not associated with the course of PD.</description><subject>Alleles</subject><subject>Amine oxidase (flavin-containing)</subject><subject>Aromatic-L-amino-acid decarboxylase</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Carrier Proteins - genetics</subject><subject>Cell Biology</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Dihydroxyphenylalanine</subject><subject>Dopa Decarboxylase - genetics</subject><subject>Dopamine</subject><subject>Dopamine D1 receptors</subject><subject>Dopamine D2 receptors</subject><subject>Gene frequency</subject><subject>Genes</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Genotyping</subject><subject>Humans</subject><subject>Metabolism</subject><subject>Monoamine Oxidase - genetics</subject><subject>Movement disorders</subject><subject>Neurochemistry</subject><subject>Neurodegenerative diseases</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Nucleotides</subject><subject>Parkinson Disease - 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genetics</topic><topic>Cell Biology</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Dihydroxyphenylalanine</topic><topic>Dopa Decarboxylase - genetics</topic><topic>Dopamine</topic><topic>Dopamine D1 receptors</topic><topic>Dopamine D2 receptors</topic><topic>Gene frequency</topic><topic>Genes</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Genotyping</topic><topic>Humans</topic><topic>Metabolism</topic><topic>Monoamine Oxidase - genetics</topic><topic>Movement disorders</topic><topic>Neurochemistry</topic><topic>Neurodegenerative diseases</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Nucleotides</topic><topic>Parkinson Disease - genetics</topic><topic>Parkinson's disease</topic><topic>Patients</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prospective Studies</topic><topic>Proteomics</topic><topic>Receptors</topic><topic>Receptors, Dopamine D2 - genetics</topic><topic>Risk</topic><topic>Single-nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zapała, Barbara</creatorcontrib><creatorcontrib>Stefura, Tomasz</creatorcontrib><creatorcontrib>Piwowar, Monika</creatorcontrib><creatorcontrib>Czekalska, Sylwia</creatorcontrib><creatorcontrib>Zawada, Magdalena</creatorcontrib><creatorcontrib>Hadasik, Maria</creatorcontrib><creatorcontrib>Solnica, Bogdan</creatorcontrib><creatorcontrib>Rudzińska-Bar, Monika</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of molecular neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zapała, Barbara</au><au>Stefura, Tomasz</au><au>Piwowar, Monika</au><au>Czekalska, Sylwia</au><au>Zawada, Magdalena</au><au>Hadasik, Maria</au><au>Solnica, Bogdan</au><au>Rudzińska-Bar, Monika</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Single Nucleotide Polymorphisms of Monoamine Oxidase B, Dopamine D2 Receptor, and DOPA Decarboxylase Receptors Among Patients Treated for Parkinson’s Disease</atitle><jtitle>Journal of molecular neuroscience</jtitle><stitle>J Mol Neurosci</stitle><addtitle>J Mol Neurosci</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>72</volume><issue>4</issue><spage>812</spage><epage>819</epage><pages>812-819</pages><issn>0895-8696</issn><eissn>1559-1166</eissn><abstract>This study aimed to investigate the association between selected variants of genes related to dopamine metabolism pathways and the risk of and progression of Parkinson’s disease (PD). This prospective cohort study was conducted in one academic teaching hospital. The study was conducted on 126 patients diagnosed with idiopathic Parkinson’s disease. Blood samples were collected to conduct a genotyping of MAOB, DRD1, DRD2, and DDC genes. Genotype and allele frequencies of MAOB (rs1799836) variants were not associated with the course of PD. Genotype and allele frequencies of DRD2 (rs2283265) variants were associated with risk of dementia (
p
= 0.001) and resulted in parts II and III of the UPDRS scale (
p
= 0.001). Genotype and allele frequencies of DRD2 (rs1076560) variants were associated with risk of dementia (
p
= 0.001) and resulted in parts II and III of the UPDRS scale (
p
= 0.001). Genotype and allele frequencies of DDC (rs921451) variants were not associated with the course of PD.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35044623</pmid><doi>10.1007/s12031-022-01966-3</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2553-272X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of molecular neuroscience, 2022-04, Vol.72 (4), p.812-819 |
| issn | 0895-8696 1559-1166 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8986734 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Alleles Amine oxidase (flavin-containing) Aromatic-L-amino-acid decarboxylase Biomedical and Life Sciences Biomedicine Carrier Proteins - genetics Cell Biology Dementia Dementia disorders Dihydroxyphenylalanine Dopa Decarboxylase - genetics Dopamine Dopamine D1 receptors Dopamine D2 receptors Gene frequency Genes Genotype Genotype & phenotype Genotyping Humans Metabolism Monoamine Oxidase - genetics Movement disorders Neurochemistry Neurodegenerative diseases Neurology Neurosciences Nucleotides Parkinson Disease - genetics Parkinson's disease Patients Polymorphism, Single Nucleotide Prospective Studies Proteomics Receptors Receptors, Dopamine D2 - genetics Risk Single-nucleotide polymorphism |
| title | The Role of Single Nucleotide Polymorphisms of Monoamine Oxidase B, Dopamine D2 Receptor, and DOPA Decarboxylase Receptors Among Patients Treated for Parkinson’s Disease |
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