Metabolomics Deciphering the Potential Biomarkers of Hengqing I Prescription against Vascular Dementia
With the aging of population, vascular dementia (VaD) seriously threatens people’s health and quality of life. It is of great significance to explore biomarkers of VaD from the perspective of metabolomics and traditional Chinese medicine (TCM). Therefore, VaD was divided into kidney deficiency and b...
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| description | With the aging of population, vascular dementia (VaD) seriously threatens people’s health and quality of life. It is of great significance to explore biomarkers of VaD from the perspective of metabolomics and traditional Chinese medicine (TCM). Therefore, VaD was divided into kidney deficiency and blood stasis syndrome (KDBS) and non-KDBS according to TCM. Then, some patients received the treatment of Hengqing I (HQI) prescription. The urine of six groups (VaD group, normal group, KDBS group, non-KDBS group, HQI group, and control group) was detected on LC-MS/MS. Multivariate statistical analysis showed that the metabolic profiles of the three comparisons were significantly different. The top analysis-ready molecules of downregulated histamine and upregulated biotin, methionine, pantothenic acid, SAH, histidine, and kaempferol may be the most related metabolites. These putative biomarkers play an important role in the regulation of key metabolic processes linked to VaD. Additionally, pathway analysis showed aminoacyl-tRNA biosynthesis, and amino acids metabolic pathways were highly correlated with the occurrence of VaD. In this present paper, vitamins, amino acids, and their derivatives were selected as the basis for VaD diagnosis and treatment monitoring, and the significance of TCM classification and Hengqing I prescription in the treatment of VaD was discussed. |
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It is of great significance to explore biomarkers of VaD from the perspective of metabolomics and traditional Chinese medicine (TCM). Therefore, VaD was divided into kidney deficiency and blood stasis syndrome (KDBS) and non-KDBS according to TCM. Then, some patients received the treatment of Hengqing I (HQI) prescription. The urine of six groups (VaD group, normal group, KDBS group, non-KDBS group, HQI group, and control group) was detected on LC-MS/MS. Multivariate statistical analysis showed that the metabolic profiles of the three comparisons were significantly different. The top analysis-ready molecules of downregulated histamine and upregulated biotin, methionine, pantothenic acid, SAH, histidine, and kaempferol may be the most related metabolites. These putative biomarkers play an important role in the regulation of key metabolic processes linked to VaD. Additionally, pathway analysis showed aminoacyl-tRNA biosynthesis, and amino acids metabolic pathways were highly correlated with the occurrence of VaD. In this present paper, vitamins, amino acids, and their derivatives were selected as the basis for VaD diagnosis and treatment monitoring, and the significance of TCM classification and Hengqing I prescription in the treatment of VaD was discussed.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2022/1636145</identifier><identifier>PMID: 35399642</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Aging ; Biomarkers ; Biotin ; Chinese medicine ; Cholesterol ; Cognitive ability ; Data analysis ; Dementia ; Dementia disorders ; Histamine ; Histidine ; Kaempferol ; Metabolic pathways ; Metabolites ; Metabolomics ; Methionine ; Normal distribution ; Pantothenic acid ; Quality of life ; Statistical analysis ; Traditional Chinese medicine ; tRNA ; Urine ; Vascular dementia ; Vitamins</subject><ispartof>Evidence-based complementary and alternative medicine, 2022-03, Vol.2022, p.1636145-10</ispartof><rights>Copyright © 2022 Shengxi Meng et al.</rights><rights>Copyright © 2022 Shengxi Meng et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Shengxi Meng et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-1b6fbd0b5e0bf4b93028a1c418bc09cf81b43ba7cf30d04e1434465502e4f9313</citedby><cites>FETCH-LOGICAL-c378t-1b6fbd0b5e0bf4b93028a1c418bc09cf81b43ba7cf30d04e1434465502e4f9313</cites><orcidid>0000-0002-9922-0446 ; 0000-0002-4385-3543 ; 0000-0001-6521-8375 ; 0000-0003-0986-0966 ; 0000-0003-4422-552X ; 0000-0003-4895-8720</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986386/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986386/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35399642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Pan, Weidong</contributor><contributor>Weidong Pan</contributor><creatorcontrib>Meng, Shengxi</creatorcontrib><creatorcontrib>Li, Shaopeng</creatorcontrib><creatorcontrib>Chen, Huize</creatorcontrib><creatorcontrib>Deng, Chujun</creatorcontrib><creatorcontrib>Meng, Zeyu</creatorcontrib><creatorcontrib>Wang, Yimo</creatorcontrib><title>Metabolomics Deciphering the Potential Biomarkers of Hengqing I Prescription against Vascular Dementia</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>With the aging of population, vascular dementia (VaD) seriously threatens people’s health and quality of life. It is of great significance to explore biomarkers of VaD from the perspective of metabolomics and traditional Chinese medicine (TCM). Therefore, VaD was divided into kidney deficiency and blood stasis syndrome (KDBS) and non-KDBS according to TCM. Then, some patients received the treatment of Hengqing I (HQI) prescription. The urine of six groups (VaD group, normal group, KDBS group, non-KDBS group, HQI group, and control group) was detected on LC-MS/MS. Multivariate statistical analysis showed that the metabolic profiles of the three comparisons were significantly different. The top analysis-ready molecules of downregulated histamine and upregulated biotin, methionine, pantothenic acid, SAH, histidine, and kaempferol may be the most related metabolites. These putative biomarkers play an important role in the regulation of key metabolic processes linked to VaD. Additionally, pathway analysis showed aminoacyl-tRNA biosynthesis, and amino acids metabolic pathways were highly correlated with the occurrence of VaD. 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| subjects | Aging Biomarkers Biotin Chinese medicine Cholesterol Cognitive ability Data analysis Dementia Dementia disorders Histamine Histidine Kaempferol Metabolic pathways Metabolites Metabolomics Methionine Normal distribution Pantothenic acid Quality of life Statistical analysis Traditional Chinese medicine tRNA Urine Vascular dementia Vitamins |
| title | Metabolomics Deciphering the Potential Biomarkers of Hengqing I Prescription against Vascular Dementia |
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