p21 produces a bioactive secretome that places stressed cells under immunosurveillance

Immune cells identify and destroy damaged cells to prevent them from causing cancer or other pathologies by mechanisms that remain poorly understood. Here, we report that the cell-cycle inhibitor p21 places cells under immunosurveillance to establish a biological timer mechanism that controls cell f...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2021-10, Vol.374 (6567), p.eabb3420-eabb3420
Hauptverfasser:	Sturmlechner, Ines, Zhang, Cheng, Sine, Chance C, van Deursen, Erik-Jan, Jeganathan, Karthik B, Hamada, Naomi, Grasic, Jan, Friedman, David, Stutchman, Jeremy T, Can, Ismail, Hamada, Masakazu, Lim, Do Young, Lee, Jeong-Heon, Ordog, Tamas, Laberge, Remi-Martin, Shapiro, Virginia, Baker, Darren J, Li, Hu, van Deursen, Jan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Age related diseases Aging Animals Biological activity Cancer Cell cycle Cell Cycle Checkpoints Cell death Cell fate Cell Line Cell surface Cellular Senescence Chemokines Chemokines, CXC - metabolism Cyclin-dependent kinase Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cyclin-dependent kinase inhibitor p27 Cyclin-dependent kinases Cytokines Cytotoxicity Damage detection Damage prevention DNA damage Enhancers Enzyme inhibitors Genes Genes, ras Genetic screening Genotype & phenotype GTP-binding protein Hepatocytes - immunology Hepatocytes - metabolism Humans Immune clearance Immune response Immune system Immunologic Surveillance Immunosurveillance Impact damage Kinases Liver Logical Thinking Lymphocytes Lymphocytes T Macrophages Macrophages - immunology Macrophages - metabolism Mice Mice, Transgenic Normalizing Phenotypes Proteins Proto-Oncogene Proteins p21(ras) - metabolism Recognition Repair Retina Retinoblastoma Retinoblastoma Protein - metabolism Senescence Stress, Physiological Stresses T-Lymphocytes, Cytotoxic - immunology Transcription factors Transcription, Genetic Tumor suppression Tumors
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