Too Good to Be True? Evaluation of Colonoscopy Sensitivity Assumptions Used in Policy Models

Too Good to Be True? Evaluation of Colonoscopy Sensitivity Assumptions Used in Policy Models

Models can help guide colorectal cancer screening policy. Although models are carefully calibrated and validated, there is less scrutiny of assumptions about test performance. We examined the validity of the CRC-SPIN model and colonoscopy sensitivity assumptions. Standard sensitivity assumptions, co...

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Veröffentlicht in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2022-04, Vol.31 (4), p.775-782
Hauptverfasser: Rutter, Carolyn M, Nascimento de Lima, Pedro, Lee, Jeffrey K, Ozik, Jonathan
Format: Artikel
Sprache:eng
Schlagworte:
Adenoma - diagnosis
Adenoma - epidemiology
Colonoscopy - methods
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - prevention & control
Early Detection of Cancer - methods
Humans
Policy
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Zusammenfassung:Models can help guide colorectal cancer screening policy. Although models are carefully calibrated and validated, there is less scrutiny of assumptions about test performance. We examined the validity of the CRC-SPIN model and colonoscopy sensitivity assumptions. Standard sensitivity assumptions, consistent with published decision analyses, assume sensitivity equal to 0.75 for diminutive adenomas (
ISSN:1055-9965
1538-7755
DOI:10.1158/1055-9965.EPI-21-1001