Decorin Protects Retinal Pigment Epithelium Cells from Oxidative Stress and Apoptosis via AMPK-mTOR-Regulated Autophagy

Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss among the elderly worldwide with unidentified pathogenesis and limited therapeutic options. Oxidative stress-induced damage to the retinal pigment epithelium (RPE) is central in the development and progression of...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2022, Vol.2022, p.3955748-17
Hauptverfasser:	Xie, Xinyi, Li, Duo, Cui, Yuqing, Xie, Tianhua, Cai, Jiping, Yao, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aging AMP-Activated Protein Kinases - metabolism Apoptosis Autophagy Decorin - metabolism Decorin - pharmacology Flow cytometry Growth factors Humans Hydrogen Peroxide - metabolism Hydrogen Peroxide - toxicity Macular degeneration Macular Degeneration - pathology Membranes Older people Oxidative Stress Pathogenesis Reactive oxygen species Reactive Oxygen Species - metabolism Reagents Retinal Pigment Epithelium - metabolism TOR Serine-Threonine Kinases - metabolism Variance analysis
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