Protective Effects of a synthetic glycosaminoglycan mimetic (OTR4132) in a rat immunotoxic lesion model of septohippocampal cholinergic degeneration

Using a partial hippocampal cholinergic denervation model, we assessed the effects of the RGTA ® named OTR4132, a synthetic heparan-mimetic biopolymer with neuroprotective/neurotrophic properties. Long-Evans male rats were injected with the cholinergic immunotoxin 192 IgG-saporin into the medial sep...

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Veröffentlicht in:	Glycoconjugate journal 2022-02, Vol.39 (1), p.107-130
Hauptverfasser:	Pereira, Patricia Marques, Papy-Garcia, Dulce, Barritault, Denis, Chiappini, Franck, Jackisch, Rolf, Schimchowitsch, Sarah, Cassel, Jean-Christophe
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (muscarinic) Acetylcholinesterase Acetyltransferase Animals Biochemistry Biomedical and Life Sciences Biopolymers Blood-brain barrier Choline O-acetyltransferase Cholinergic Agents - pharmacology Denervation Diagonal band of Broca Fluorescein Glycosaminoglycans Glycosaminoglycans - pharmacology Heparin Hippocampus Immunoglobulin G Internalization Lesions Life Sciences Male Neurodegeneration Neurons Neuroprotection Original Original Article Pathology Rats Rats, Long-Evans Ribosome Inactivating Proteins, Type 1 Rodents Saporin Septum Structure-function relationships Ventricle (lateral)
Online-Zugang:	Volltext
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