Modeling clonal hematopoiesis in umbilical cord blood cells by CRISPR/Cas9

To investigate clonal hematopoiesis associated gene mutations in vitro and to unravel the direct impact on the human stem and progenitor cell (HSPC) compartment, we targeted healthy, young hematopoietic progenitor cells, derived from umbilical cord blood samples, with CRISPR/Cas9 technology. Site-sp...

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Veröffentlicht in:	Leukemia 2022-04, Vol.36 (4), p.1102-1110
Hauptverfasser:	Christen, Friederike, Hablesreiter, Raphael, Hoyer, Kaja, Hennch, Cornelius, Maluck-Böttcher, Antje, Segler, Angela, Madadi, Annett, Frick, Mareike, Bullinger, Lars, Briest, Franziska, Damm, Frederik
Format:	Artikel
Sprache:	eng
Schlagworte:	42/41 45/23 631/208/68 631/67/1990/1673 692/308/575 692/420/755 Blood cells Cancer Research CD34 antigen Cell culture Cell self-renewal Clonal Hematopoiesis Colonies Composition Cord blood CRISPR CRISPR-Cas Systems Critical Care Medicine Culture Epigenetics Fetal Blood Hematology Hematopoiesis Hematopoiesis - genetics Hematopoietic Stem Cells Humans Intensive Internal Medicine Medicine Medicine & Public Health Mutants Mutation Oncology Progenitor cells Umbilical cord
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