Wt1 transcription factor impairs cardiomyocyte specification and drives a phenotypic switch from myocardium to epicardium

During development, the heart grows by addition of progenitor cells to the poles of the primordial heart tube. In the zebrafish, Wilms tumor 1 transcription factor a (wt1a) and b (wt1b) genes are expressed in the pericardium, at the venous pole of the heart. From this pericardial layer, the proepica...

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Veröffentlicht in:	Development (Cambridge) 2022-03, Vol.149 (6)
Hauptverfasser:	Marques, Ines J, Ernst, Alexander, Arora, Prateek, Vianin, Andrej, Hetke, Tanja, Sanz-Morejón, Andrés, Naumann, Uta, Odriozola, Adolfo, Langa, Xavier, Andrés-Delgado, Laura, Zuber, Benoît, Torroja, Carlos, Osterwalder, Marco, Simões, Filipa C, Englert, Christoph, Mercader, Nadia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiovascular Development and Regeneration Gene Expression Regulation, Developmental Myocardium - metabolism Myocytes, Cardiac - metabolism Pericardium - metabolism Transcription Factors - genetics Transcription Factors - metabolism WT1 Proteins - genetics WT1 Proteins - metabolism Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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