Role of B Cells in Responses to Checkpoint Blockade Immunotherapy and Overall Survival of Cancer Patients

The role of B cells in the tumor microenvironment and B-cell-mediated antitumor immune responses remains relatively understudied. Recent seminal studies have discovered that B cells and associated tertiary lymphoid structures correlate with responses to checkpoint blockade immunotherapy and are prog...

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Veröffentlicht in:	Clinical cancer research 2021-11, Vol.27 (22), p.6075-6082
Hauptverfasser:	Kim, Sangwoo S, Sumner, Whitney A, Miyauchi, Sayuri, Cohen, Ezra E W, Califano, Joseph A, Sharabi, Andrew B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation - genetics Antibody Formation - immunology Antigen-Presenting Cells - immunology Antigen-Presenting Cells - metabolism B-Lymphocytes - drug effects B-Lymphocytes - immunology B-Lymphocytes - metabolism Biomarkers Disease Management Humans Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use Immunomodulation Lymphopoiesis Molecular Targeted Therapy - adverse effects Molecular Targeted Therapy - methods Neoplasms - diagnosis Neoplasms - etiology Neoplasms - mortality Neoplasms - therapy Prognosis Treatment Outcome Tumor Microenvironment - genetics Tumor Microenvironment - immunology
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