Bergenin, a PPARγ agonist, inhibits Th17 differentiation and subsequent neutrophilic asthma by preventing GLS1-dependent glutaminolysis

Bergenin is a natural PPARγ agonist that can prevent neutrophil aggregation, and often be used in clinics for treating respiratory diseases. Recent data show that Th17 cells are important for neutrophil aggregation and asthma through secreting IL-17A. In this study, we investigated the effects of be...

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Veröffentlicht in:	Acta pharmacologica Sinica 2022-04, Vol.43 (4), p.963-976
Hauptverfasser:	Yang, Ling, Zheng, Yun, Miao, Yu-meng, Yan, Wen-xin, Geng, Yan-zhi, Dai, Yue, Wei, Zhi-feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animals Antigen-presenting cells Apoptosis Asthma Asthma - drug therapy Asthma - pathology Benzopyrans - pharmacology Benzopyrans - therapeutic use Biomedical and Life Sciences Biomedicine CD4 antigen Cell Differentiation E-cadherin Gene expression Glutaminase Glutamine Helper cells Immunology Interleukin 21 Interleukin 22 Interleukin 23 Interleukin 6 Internal Medicine Ketoglutaric acid Leukocytes (neutrophilic) Lymph nodes Lymphocytes Lymphocytes T Medical Microbiology Mice Neutrophils Peroxisome proliferator-activated receptors Pharmacology/Toxicology Phosphorylation PPAR gamma - metabolism Proteasomes Respiratory diseases Th17 Cells Ubiquitin Vaccine
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