Renal Dysfunction is an Independent Risk Factor for Rebleeding After Endoscopic Hemostasis in Patients with Peptic Ulcer Bleeding
Despite the progress in endoscopic hemostasis and pharmacological treatment, the mortality rate of peptic ulcer bleeding remains at 5-10%. Rebleeding after peptic ulcer bleeding is believed to be a risk factor for mortality. This study aimed to evaluate whether renal dysfunction is a predictor of re...
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| Veröffentlicht in: | The Turkish Journal of Gastroenterology 2021-08, Vol.32 (8), p.622-630 |
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| creator | Ogiyama, Hideharu Tsutsui, Shusaku Murayama, Yoko Matsushima, Kensuke Maeda, Shingo Satake, Shin Seto, Kayo Horiki, Masashi Sanomura, Tamana Imanaka, Kazuho Iishi, Hiroyasu |
| description | Despite the progress in endoscopic hemostasis and pharmacological treatment, the mortality rate of peptic ulcer bleeding remains at 5-10%. Rebleeding after peptic ulcer bleeding is believed to be a risk factor for mortality. This study aimed to evaluate whether renal dysfunction is a predictor of rebleeding after endoscopic hemostasis in patients with peptic ulcer bleeding.
In this retrospective study, consecutive patients with peptic ulcer bleeding who underwent endoscopic hemostasis at our Hospital from January 2010 to December 2018 were enrolled. The relationship between rebleeding within 30 days after endoscopic hemostasis and the patients' admission and endoscopic characteristics were analyzed using univariate and multivariate regression models.
Out of 274 patients with peptic ulcer bleeding, 17 (6.2%) patients experienced rebleeding. In the analysis of the patients' admission characteristics, estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2 was an independent risk factor for rebleeding (odds ratio 4.77, 95% confidence interval 1.168-18.211, p = 0.03). Patients with eGFR < 15 mL/min/1.73 m2 with or without hemodialysis had the highest rebleeding rate at 36.8%. With respect to endoscopic characteristics, the rate of rebleeding was associated with combination therapy (p < 0.0001) and active bleeding (p = 0.03).
Renal dysfunction might be an independent risk factor for rebleeding after endoscopic hemostasis in patients with peptic ulcer bleeding. |
| doi_str_mv | 10.5152/tjg.2021.20202 |
| format | Article |
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In this retrospective study, consecutive patients with peptic ulcer bleeding who underwent endoscopic hemostasis at our Hospital from January 2010 to December 2018 were enrolled. The relationship between rebleeding within 30 days after endoscopic hemostasis and the patients' admission and endoscopic characteristics were analyzed using univariate and multivariate regression models.
Out of 274 patients with peptic ulcer bleeding, 17 (6.2%) patients experienced rebleeding. In the analysis of the patients' admission characteristics, estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2 was an independent risk factor for rebleeding (odds ratio 4.77, 95% confidence interval 1.168-18.211, p = 0.03). Patients with eGFR < 15 mL/min/1.73 m2 with or without hemodialysis had the highest rebleeding rate at 36.8%. With respect to endoscopic characteristics, the rate of rebleeding was associated with combination therapy (p < 0.0001) and active bleeding (p = 0.03).
Renal dysfunction might be an independent risk factor for rebleeding after endoscopic hemostasis in patients with peptic ulcer bleeding.</description><identifier>ISSN: 1300-4948</identifier><identifier>EISSN: 2148-5607</identifier><identifier>DOI: 10.5152/tjg.2021.20202</identifier><identifier>PMID: 34528875</identifier><language>eng</language><publisher>Turkey: AVES</publisher><subject>Antiulcer drugs ; Care and treatment ; Causes of ; Complications and side effects ; Diseases ; Endoscopy ; Gastrointestinal bleeding ; GASTROINTESTINAL TRACT ; Health aspects ; Hemostasis ; Hemostasis, Endoscopic ; Humans ; Kidney diseases ; Kidney Diseases - complications ; Medical research ; Medicine, Experimental ; Methods ; Original ; Peptic ulcer ; Peptic Ulcer Hemorrhage - etiology ; Peptic Ulcer Hemorrhage - therapy ; Recurrence ; Relapse ; Retrospective Studies ; Risk Factors</subject><ispartof>The Turkish Journal of Gastroenterology, 2021-08, Vol.32 (8), p.622-630</ispartof><rights>COPYRIGHT 2021 AVES</rights><rights>Copyright 2021 by The Turkish Society of Gastroenterology 2021 Turkish Society of Gastroenterology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975289/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975289/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34528875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogiyama, Hideharu</creatorcontrib><creatorcontrib>Tsutsui, Shusaku</creatorcontrib><creatorcontrib>Murayama, Yoko</creatorcontrib><creatorcontrib>Matsushima, Kensuke</creatorcontrib><creatorcontrib>Maeda, Shingo</creatorcontrib><creatorcontrib>Satake, Shin</creatorcontrib><creatorcontrib>Seto, Kayo</creatorcontrib><creatorcontrib>Horiki, Masashi</creatorcontrib><creatorcontrib>Sanomura, Tamana</creatorcontrib><creatorcontrib>Imanaka, Kazuho</creatorcontrib><creatorcontrib>Iishi, Hiroyasu</creatorcontrib><creatorcontrib>Department of Gastroenterology and Hepatology, Itami City Hospital, Itami, Hyogo, Japan</creatorcontrib><title>Renal Dysfunction is an Independent Risk Factor for Rebleeding After Endoscopic Hemostasis in Patients with Peptic Ulcer Bleeding</title><title>The Turkish Journal of Gastroenterology</title><addtitle>Turk J Gastroenterol</addtitle><description>Despite the progress in endoscopic hemostasis and pharmacological treatment, the mortality rate of peptic ulcer bleeding remains at 5-10%. Rebleeding after peptic ulcer bleeding is believed to be a risk factor for mortality. This study aimed to evaluate whether renal dysfunction is a predictor of rebleeding after endoscopic hemostasis in patients with peptic ulcer bleeding.
In this retrospective study, consecutive patients with peptic ulcer bleeding who underwent endoscopic hemostasis at our Hospital from January 2010 to December 2018 were enrolled. The relationship between rebleeding within 30 days after endoscopic hemostasis and the patients' admission and endoscopic characteristics were analyzed using univariate and multivariate regression models.
Out of 274 patients with peptic ulcer bleeding, 17 (6.2%) patients experienced rebleeding. In the analysis of the patients' admission characteristics, estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2 was an independent risk factor for rebleeding (odds ratio 4.77, 95% confidence interval 1.168-18.211, p = 0.03). Patients with eGFR < 15 mL/min/1.73 m2 with or without hemodialysis had the highest rebleeding rate at 36.8%. With respect to endoscopic characteristics, the rate of rebleeding was associated with combination therapy (p < 0.0001) and active bleeding (p = 0.03).
Renal dysfunction might be an independent risk factor for rebleeding after endoscopic hemostasis in patients with peptic ulcer bleeding.</description><subject>Antiulcer drugs</subject><subject>Care and treatment</subject><subject>Causes of</subject><subject>Complications and side effects</subject><subject>Diseases</subject><subject>Endoscopy</subject><subject>Gastrointestinal bleeding</subject><subject>GASTROINTESTINAL TRACT</subject><subject>Health aspects</subject><subject>Hemostasis</subject><subject>Hemostasis, Endoscopic</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Kidney Diseases - complications</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Methods</subject><subject>Original</subject><subject>Peptic ulcer</subject><subject>Peptic Ulcer Hemorrhage - etiology</subject><subject>Peptic Ulcer Hemorrhage - therapy</subject><subject>Recurrence</subject><subject>Relapse</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><issn>1300-4948</issn><issn>2148-5607</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1vFCEYxidGY7fVq0dD4sXLrMP3zMVkW1vbpInNxp4JMC9b6gyMA6vpsf-5rF0bjR4MARL4PQ_w8lTVK9wsOebkXb7dLElD8G5oyJNqQTBray4a-bRaYNo0NetYe1AdpnTbNLTFgjyvDijjpG0lX1T3awh6QB_uktsGm30MyCekA7oIPUxQhpDR2qcv6EzbHGfkSl-DGQB6HzZo5TLM6DT0Mdk4eYvOYYwp61RcfEBXOvvikNB3n2_QFUy5INeDLZrjvcWL6pnTQ4KX-_mouj47_XxyXl9--nhxsrqsLZNdrp3Emgjg2khsjZU95lrgpne47TEzuGOdFMYaAOo6XdjWtFyAMMwApRLoUfX-wXfamhF6W64160FNsx_1fKei9urPneBv1CZ-U20nS7W6YvB2bzDHr1tIWY0-WRgGHSBukyJcUsaw5KKgbx7QjR5A-eBicbQ7XK2EFIISKkihlv-gSuth9DYGcL6sF0GLy4fx7v8Ff51g55jSDO7xubhRu_yokh-1y4_6mZ8ieP17kR7xX4GhPwCAM8Jw</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Ogiyama, Hideharu</creator><creator>Tsutsui, Shusaku</creator><creator>Murayama, Yoko</creator><creator>Matsushima, Kensuke</creator><creator>Maeda, Shingo</creator><creator>Satake, Shin</creator><creator>Seto, Kayo</creator><creator>Horiki, Masashi</creator><creator>Sanomura, Tamana</creator><creator>Imanaka, Kazuho</creator><creator>Iishi, Hiroyasu</creator><general>AVES</general><general>Turkish Society of Gastroenterology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210801</creationdate><title>Renal Dysfunction is an Independent Risk Factor for Rebleeding After Endoscopic Hemostasis in Patients with Peptic Ulcer Bleeding</title><author>Ogiyama, Hideharu ; Tsutsui, Shusaku ; Murayama, Yoko ; Matsushima, Kensuke ; Maeda, Shingo ; Satake, Shin ; Seto, Kayo ; Horiki, Masashi ; Sanomura, Tamana ; Imanaka, Kazuho ; Iishi, Hiroyasu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-f71a26e5ab71cbc7d15a610df18d14b194976bcbee3f9a1a28b856e6b4be337e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antiulcer drugs</topic><topic>Care and treatment</topic><topic>Causes of</topic><topic>Complications and side effects</topic><topic>Diseases</topic><topic>Endoscopy</topic><topic>Gastrointestinal bleeding</topic><topic>GASTROINTESTINAL TRACT</topic><topic>Health aspects</topic><topic>Hemostasis</topic><topic>Hemostasis, Endoscopic</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>Kidney Diseases - complications</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Methods</topic><topic>Original</topic><topic>Peptic ulcer</topic><topic>Peptic Ulcer Hemorrhage - etiology</topic><topic>Peptic Ulcer Hemorrhage - therapy</topic><topic>Recurrence</topic><topic>Relapse</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogiyama, Hideharu</creatorcontrib><creatorcontrib>Tsutsui, Shusaku</creatorcontrib><creatorcontrib>Murayama, Yoko</creatorcontrib><creatorcontrib>Matsushima, Kensuke</creatorcontrib><creatorcontrib>Maeda, Shingo</creatorcontrib><creatorcontrib>Satake, Shin</creatorcontrib><creatorcontrib>Seto, Kayo</creatorcontrib><creatorcontrib>Horiki, Masashi</creatorcontrib><creatorcontrib>Sanomura, Tamana</creatorcontrib><creatorcontrib>Imanaka, Kazuho</creatorcontrib><creatorcontrib>Iishi, Hiroyasu</creatorcontrib><creatorcontrib>Department of Gastroenterology and Hepatology, Itami City Hospital, Itami, Hyogo, Japan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Turkish Journal of Gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogiyama, Hideharu</au><au>Tsutsui, Shusaku</au><au>Murayama, Yoko</au><au>Matsushima, Kensuke</au><au>Maeda, Shingo</au><au>Satake, Shin</au><au>Seto, Kayo</au><au>Horiki, Masashi</au><au>Sanomura, Tamana</au><au>Imanaka, Kazuho</au><au>Iishi, Hiroyasu</au><aucorp>Department of Gastroenterology and Hepatology, Itami City Hospital, Itami, Hyogo, Japan</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal Dysfunction is an Independent Risk Factor for Rebleeding After Endoscopic Hemostasis in Patients with Peptic Ulcer Bleeding</atitle><jtitle>The Turkish Journal of Gastroenterology</jtitle><addtitle>Turk J Gastroenterol</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>32</volume><issue>8</issue><spage>622</spage><epage>630</epage><pages>622-630</pages><issn>1300-4948</issn><eissn>2148-5607</eissn><abstract>Despite the progress in endoscopic hemostasis and pharmacological treatment, the mortality rate of peptic ulcer bleeding remains at 5-10%. Rebleeding after peptic ulcer bleeding is believed to be a risk factor for mortality. This study aimed to evaluate whether renal dysfunction is a predictor of rebleeding after endoscopic hemostasis in patients with peptic ulcer bleeding.
In this retrospective study, consecutive patients with peptic ulcer bleeding who underwent endoscopic hemostasis at our Hospital from January 2010 to December 2018 were enrolled. The relationship between rebleeding within 30 days after endoscopic hemostasis and the patients' admission and endoscopic characteristics were analyzed using univariate and multivariate regression models.
Out of 274 patients with peptic ulcer bleeding, 17 (6.2%) patients experienced rebleeding. In the analysis of the patients' admission characteristics, estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2 was an independent risk factor for rebleeding (odds ratio 4.77, 95% confidence interval 1.168-18.211, p = 0.03). Patients with eGFR < 15 mL/min/1.73 m2 with or without hemodialysis had the highest rebleeding rate at 36.8%. With respect to endoscopic characteristics, the rate of rebleeding was associated with combination therapy (p < 0.0001) and active bleeding (p = 0.03).
Renal dysfunction might be an independent risk factor for rebleeding after endoscopic hemostasis in patients with peptic ulcer bleeding.</abstract><cop>Turkey</cop><pub>AVES</pub><pmid>34528875</pmid><doi>10.5152/tjg.2021.20202</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Antiulcer drugs Care and treatment Causes of Complications and side effects Diseases Endoscopy Gastrointestinal bleeding GASTROINTESTINAL TRACT Health aspects Hemostasis Hemostasis, Endoscopic Humans Kidney diseases Kidney Diseases - complications Medical research Medicine, Experimental Methods Original Peptic ulcer Peptic Ulcer Hemorrhage - etiology Peptic Ulcer Hemorrhage - therapy Recurrence Relapse Retrospective Studies Risk Factors |
| title | Renal Dysfunction is an Independent Risk Factor for Rebleeding After Endoscopic Hemostasis in Patients with Peptic Ulcer Bleeding |
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