Heterofunctional carbosilane polyphenolic dendrons: new antioxidants platforms
Reactive oxygen species (ROS) play a critical role in different human pathophysiological processes. ROS, together with nitrogen reactive species, generated as by-products of cellular metabolism or external factors, affects intracellular redox homeostasis. Redox-active groups found in proteins and ot...
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| Veröffentlicht in: | RSC advances 2022-03, Vol.12 (17), p.10280-10288 |
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| creator | Sanz Del Olmo, Natalia García, Juan Carlos Gómez, Rafael de la Mata, F Javier Ortega, Paula |
| description | Reactive oxygen species (ROS) play a critical role in different human pathophysiological processes. ROS, together with nitrogen reactive species, generated as by-products of cellular metabolism or external factors, affects intracellular redox homeostasis. Redox-active groups found in proteins and other compounds such as polyphenols are involved in maintaining intracellular redox homeostasis. In this work, a new family of heterofunctional first-generation carbosilane dendrons functionalised with different polyphenols at the focal point and dimethylammonium groups at the periphery has been obtained through two synthetic strategies: reductive amination and straightforward amidation reaction. Their antioxidant activity has been evaluated through two spectrophotometric methods: ferric reducing antioxidant power (FRAP) assay and 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay to establish a correlation between the number of hydroxyl groups and the antioxidant activity. |
| doi_str_mv | 10.1039/d1ra08224h |
| format | Article |
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| ispartof | RSC advances, 2022-03, Vol.12 (17), p.10280-10288 |
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| language | eng |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Antioxidants Chemistry Homeostasis Hydroxyl groups Polyphenols Scavenging Spectrophotometry |
| title | Heterofunctional carbosilane polyphenolic dendrons: new antioxidants platforms |
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