Multivitamin Supplementation Is Associated with Greater Adequacy of Gestational Weight Gain among Pregnant Women in Tanzania
Gestational weight gain (GWG) is a modifiable risk factor associated with adverse birth outcomes. Studies have shown that the provision of multiple micronutrient supplements to pregnant women reduces the risk of low birth weight. However, the effect of multiple micronutrient supplements on GWG has b...
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| Veröffentlicht in: | The Journal of nutrition 2022-04, Vol.152 (4), p.1091-1098 |
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| creator | Liu, Enju Wang, Dongqing Darling, Anne Marie Perumal, Nandita Wang, Molin Urassa, Willy Pembe, Andrea Fawzi, Wafaie W |
| description | Gestational weight gain (GWG) is a modifiable risk factor associated with adverse birth outcomes. Studies have shown that the provision of multiple micronutrient supplements to pregnant women reduces the risk of low birth weight. However, the effect of multiple micronutrient supplements on GWG has been understudied.
We examined the effect of daily supplementation of pregnant women with multivitamins on GWG in relation to the GWG recommendation by the Institute of Medicine (IOM).
Pregnant women with gestational age between 12 and 27 wk were randomly assigned to receive daily multivitamins or placebo until delivery. Weight was measured at enrollment and every follow-up visit. Percentage adequacy of GWG was calculated as actual GWG divided by the recommended GWG according to the IOM recommendation. Binary outcomes included severely inadequate ( |
| doi_str_mv | 10.1093/jn/nxab448 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8970983</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/jn/nxab448</oup_id><els_id>S0022316622006034</els_id><sourcerecordid>2615300025</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-bdd369d823cebeb1321a788830c3a3cc5cbcba5001d69d803fb07c3f383b6e8c3</originalsourceid><addsrcrecordid>eNp9kVGL1DAUhYMo7rj64g-QgAgi1E2atpO-CMOi48KKgiv7GG7T25kMbdJN0tEVf7wZOi4q4lNI8t3DPecQ8pSz15zV4mxnz-w3aIpC3iMLXhY8qzhj98mCsTzPBK-qE_IohB1jjBe1fEhORFFXhazZgvz4MPXR7E2EwVj6eRrHHge0EaJxll4EugrBaQMRW_rVxC1de0wXT1ct3kygb6nr6BrDPAA9vUaz2Ua6hiQHg7Mb-snjxoKN9NolZZrer8B-B2vgMXnQQR_wyfE8JV_evb06f59dflxfnK8uM11IHrOmbUVVtzIXGhtsuMg5LKWUgmkBQutSN7qBMrlrDxgTXcOWWnRCiqZCqcUpeTPrjlMzYKuTPw-9Gr0ZwN8qB0b9-WPNVm3cXsl6yWopksDLo4B3N1NyqwYTNPY9WHRTUHnFS5HizcuEPv8L3bnJp2QOVMllUclllahXM6W9C8Fjd7cMZ-pQqtpZdSw1wc9-X_8O_dViAl7MgJvG_wsVM4cp7L1Br4I2aDW2xqOOqnXmX2M_AcXEwFE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2651846876</pqid></control><display><type>article</type><title>Multivitamin Supplementation Is Associated with Greater Adequacy of Gestational Weight Gain among Pregnant Women in Tanzania</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Liu, Enju ; Wang, Dongqing ; Darling, Anne Marie ; Perumal, Nandita ; Wang, Molin ; Urassa, Willy ; Pembe, Andrea ; Fawzi, Wafaie W</creator><creatorcontrib>Liu, Enju ; Wang, Dongqing ; Darling, Anne Marie ; Perumal, Nandita ; Wang, Molin ; Urassa, Willy ; Pembe, Andrea ; Fawzi, Wafaie W</creatorcontrib><description>Gestational weight gain (GWG) is a modifiable risk factor associated with adverse birth outcomes. Studies have shown that the provision of multiple micronutrient supplements to pregnant women reduces the risk of low birth weight. However, the effect of multiple micronutrient supplements on GWG has been understudied.
We examined the effect of daily supplementation of pregnant women with multivitamins on GWG in relation to the GWG recommendation by the Institute of Medicine (IOM).
Pregnant women with gestational age between 12 and 27 wk were randomly assigned to receive daily multivitamins or placebo until delivery. Weight was measured at enrollment and every follow-up visit. Percentage adequacy of GWG was calculated as actual GWG divided by the recommended GWG according to the IOM recommendation. Binary outcomes included severely inadequate (<70%), inadequate (<90%), and excessive GWG (≥125%). The analysis included 7573 women with singleton pregnancies. Multiple linear regression models were used to examine the association between multivitamin supplementation and percentage adequacy of GWG, and log-binomial models were used for binary outcomes.
The mean percentage adequacy of GWG was 96.7% in the multivitamin arm and 94.4% in the placebo arm, with a mean difference of 2.3% (95% CI: 0.3%, 4.2%; P = 0.022). Compared with women in the placebo arm, those who received multivitamins had a lower risk of severely inadequate GWG (RR: 0.90; 95% CI: 0.83, 0.97; P = 0.008) and inadequate GWG (RR: 0.95; 95% CI: 0.91, 0.99; P = 0.018). No significant difference was found in excessive GWG.
Multivitamin supplementation increased GWG and reduced the risk of severely inadequate and inadequate GWG among pregnant women in Tanzania. Together with previously reported beneficial effects of the supplements on birth outcomes in low- and middle-income countries, our findings support scaling up the use of prenatal supplements that include multivitamins in addition to iron and folic acid. This trial was registered at clinicaltrials.gov as NCT00197548.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/nxab448</identifier><identifier>PMID: 34964890</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adequacy ; Adolescent ; Adult ; Birth weight ; Body Mass Index ; Child ; Dietary Supplements ; Female ; Folic acid ; Gestational age ; Gestational Weight Gain ; Humans ; Institute of Medicine ; Low birth weight ; Nutrition ; Nutritional Epidemiology ; Placebos ; Pregnancy ; Pregnancy Outcome ; Pregnant Women ; Prenatal experience ; prenatal multivitamin supplementation ; Regression analysis ; Regression models ; Risk analysis ; Risk factors ; Supplements ; Tanzania ; Vitamins ; Vitamins - therapeutic use ; Womens health ; Young Adult</subject><ispartof>The Journal of nutrition, 2022-04, Vol.152 (4), p.1091-1098</ispartof><rights>2022 American Society for Nutrition.</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition. 2022</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.</rights><rights>Copyright American Institute of Nutrition Apr 2022</rights><rights>Published by Oxford University Press on behalf of the American Society for Nutrition. All rights reserved. 2022 American Society for Nutrition.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-bdd369d823cebeb1321a788830c3a3cc5cbcba5001d69d803fb07c3f383b6e8c3</citedby><cites>FETCH-LOGICAL-c481t-bdd369d823cebeb1321a788830c3a3cc5cbcba5001d69d803fb07c3f383b6e8c3</cites><orcidid>0000-0003-3624-4405</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,782,786,887,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34964890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Enju</creatorcontrib><creatorcontrib>Wang, Dongqing</creatorcontrib><creatorcontrib>Darling, Anne Marie</creatorcontrib><creatorcontrib>Perumal, Nandita</creatorcontrib><creatorcontrib>Wang, Molin</creatorcontrib><creatorcontrib>Urassa, Willy</creatorcontrib><creatorcontrib>Pembe, Andrea</creatorcontrib><creatorcontrib>Fawzi, Wafaie W</creatorcontrib><title>Multivitamin Supplementation Is Associated with Greater Adequacy of Gestational Weight Gain among Pregnant Women in Tanzania</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Gestational weight gain (GWG) is a modifiable risk factor associated with adverse birth outcomes. Studies have shown that the provision of multiple micronutrient supplements to pregnant women reduces the risk of low birth weight. However, the effect of multiple micronutrient supplements on GWG has been understudied.
We examined the effect of daily supplementation of pregnant women with multivitamins on GWG in relation to the GWG recommendation by the Institute of Medicine (IOM).
Pregnant women with gestational age between 12 and 27 wk were randomly assigned to receive daily multivitamins or placebo until delivery. Weight was measured at enrollment and every follow-up visit. Percentage adequacy of GWG was calculated as actual GWG divided by the recommended GWG according to the IOM recommendation. Binary outcomes included severely inadequate (<70%), inadequate (<90%), and excessive GWG (≥125%). The analysis included 7573 women with singleton pregnancies. Multiple linear regression models were used to examine the association between multivitamin supplementation and percentage adequacy of GWG, and log-binomial models were used for binary outcomes.
The mean percentage adequacy of GWG was 96.7% in the multivitamin arm and 94.4% in the placebo arm, with a mean difference of 2.3% (95% CI: 0.3%, 4.2%; P = 0.022). Compared with women in the placebo arm, those who received multivitamins had a lower risk of severely inadequate GWG (RR: 0.90; 95% CI: 0.83, 0.97; P = 0.008) and inadequate GWG (RR: 0.95; 95% CI: 0.91, 0.99; P = 0.018). No significant difference was found in excessive GWG.
Multivitamin supplementation increased GWG and reduced the risk of severely inadequate and inadequate GWG among pregnant women in Tanzania. Together with previously reported beneficial effects of the supplements on birth outcomes in low- and middle-income countries, our findings support scaling up the use of prenatal supplements that include multivitamins in addition to iron and folic acid. This trial was registered at clinicaltrials.gov as NCT00197548.</description><subject>Adequacy</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Birth weight</subject><subject>Body Mass Index</subject><subject>Child</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>Folic acid</subject><subject>Gestational age</subject><subject>Gestational Weight Gain</subject><subject>Humans</subject><subject>Institute of Medicine</subject><subject>Low birth weight</subject><subject>Nutrition</subject><subject>Nutritional Epidemiology</subject><subject>Placebos</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnant Women</subject><subject>Prenatal experience</subject><subject>prenatal multivitamin supplementation</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Supplements</subject><subject>Tanzania</subject><subject>Vitamins</subject><subject>Vitamins - therapeutic use</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVGL1DAUhYMo7rj64g-QgAgi1E2atpO-CMOi48KKgiv7GG7T25kMbdJN0tEVf7wZOi4q4lNI8t3DPecQ8pSz15zV4mxnz-w3aIpC3iMLXhY8qzhj98mCsTzPBK-qE_IohB1jjBe1fEhORFFXhazZgvz4MPXR7E2EwVj6eRrHHge0EaJxll4EugrBaQMRW_rVxC1de0wXT1ct3kygb6nr6BrDPAA9vUaz2Ua6hiQHg7Mb-snjxoKN9NolZZrer8B-B2vgMXnQQR_wyfE8JV_evb06f59dflxfnK8uM11IHrOmbUVVtzIXGhtsuMg5LKWUgmkBQutSN7qBMrlrDxgTXcOWWnRCiqZCqcUpeTPrjlMzYKuTPw-9Gr0ZwN8qB0b9-WPNVm3cXsl6yWopksDLo4B3N1NyqwYTNPY9WHRTUHnFS5HizcuEPv8L3bnJp2QOVMllUclllahXM6W9C8Fjd7cMZ-pQqtpZdSw1wc9-X_8O_dViAl7MgJvG_wsVM4cp7L1Br4I2aDW2xqOOqnXmX2M_AcXEwFE</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Liu, Enju</creator><creator>Wang, Dongqing</creator><creator>Darling, Anne Marie</creator><creator>Perumal, Nandita</creator><creator>Wang, Molin</creator><creator>Urassa, Willy</creator><creator>Pembe, Andrea</creator><creator>Fawzi, Wafaie W</creator><general>Elsevier Inc</general><general>Oxford University Press</general><general>American Institute of Nutrition</general><general>American Society for Nutrition</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3624-4405</orcidid></search><sort><creationdate>202204</creationdate><title>Multivitamin Supplementation Is Associated with Greater Adequacy of Gestational Weight Gain among Pregnant Women in Tanzania</title><author>Liu, Enju ; Wang, Dongqing ; Darling, Anne Marie ; Perumal, Nandita ; Wang, Molin ; Urassa, Willy ; Pembe, Andrea ; Fawzi, Wafaie W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-bdd369d823cebeb1321a788830c3a3cc5cbcba5001d69d803fb07c3f383b6e8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adequacy</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Birth weight</topic><topic>Body Mass Index</topic><topic>Child</topic><topic>Dietary Supplements</topic><topic>Female</topic><topic>Folic acid</topic><topic>Gestational age</topic><topic>Gestational Weight Gain</topic><topic>Humans</topic><topic>Institute of Medicine</topic><topic>Low birth weight</topic><topic>Nutrition</topic><topic>Nutritional Epidemiology</topic><topic>Placebos</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Pregnant Women</topic><topic>Prenatal experience</topic><topic>prenatal multivitamin supplementation</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Supplements</topic><topic>Tanzania</topic><topic>Vitamins</topic><topic>Vitamins - therapeutic use</topic><topic>Womens health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Enju</creatorcontrib><creatorcontrib>Wang, Dongqing</creatorcontrib><creatorcontrib>Darling, Anne Marie</creatorcontrib><creatorcontrib>Perumal, Nandita</creatorcontrib><creatorcontrib>Wang, Molin</creatorcontrib><creatorcontrib>Urassa, Willy</creatorcontrib><creatorcontrib>Pembe, Andrea</creatorcontrib><creatorcontrib>Fawzi, Wafaie W</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Enju</au><au>Wang, Dongqing</au><au>Darling, Anne Marie</au><au>Perumal, Nandita</au><au>Wang, Molin</au><au>Urassa, Willy</au><au>Pembe, Andrea</au><au>Fawzi, Wafaie W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multivitamin Supplementation Is Associated with Greater Adequacy of Gestational Weight Gain among Pregnant Women in Tanzania</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>2022-04</date><risdate>2022</risdate><volume>152</volume><issue>4</issue><spage>1091</spage><epage>1098</epage><pages>1091-1098</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><abstract>Gestational weight gain (GWG) is a modifiable risk factor associated with adverse birth outcomes. Studies have shown that the provision of multiple micronutrient supplements to pregnant women reduces the risk of low birth weight. However, the effect of multiple micronutrient supplements on GWG has been understudied.
We examined the effect of daily supplementation of pregnant women with multivitamins on GWG in relation to the GWG recommendation by the Institute of Medicine (IOM).
Pregnant women with gestational age between 12 and 27 wk were randomly assigned to receive daily multivitamins or placebo until delivery. Weight was measured at enrollment and every follow-up visit. Percentage adequacy of GWG was calculated as actual GWG divided by the recommended GWG according to the IOM recommendation. Binary outcomes included severely inadequate (<70%), inadequate (<90%), and excessive GWG (≥125%). The analysis included 7573 women with singleton pregnancies. Multiple linear regression models were used to examine the association between multivitamin supplementation and percentage adequacy of GWG, and log-binomial models were used for binary outcomes.
The mean percentage adequacy of GWG was 96.7% in the multivitamin arm and 94.4% in the placebo arm, with a mean difference of 2.3% (95% CI: 0.3%, 4.2%; P = 0.022). Compared with women in the placebo arm, those who received multivitamins had a lower risk of severely inadequate GWG (RR: 0.90; 95% CI: 0.83, 0.97; P = 0.008) and inadequate GWG (RR: 0.95; 95% CI: 0.91, 0.99; P = 0.018). No significant difference was found in excessive GWG.
Multivitamin supplementation increased GWG and reduced the risk of severely inadequate and inadequate GWG among pregnant women in Tanzania. Together with previously reported beneficial effects of the supplements on birth outcomes in low- and middle-income countries, our findings support scaling up the use of prenatal supplements that include multivitamins in addition to iron and folic acid. This trial was registered at clinicaltrials.gov as NCT00197548.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34964890</pmid><doi>10.1093/jn/nxab448</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3624-4405</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adequacy Adolescent Adult Birth weight Body Mass Index Child Dietary Supplements Female Folic acid Gestational age Gestational Weight Gain Humans Institute of Medicine Low birth weight Nutrition Nutritional Epidemiology Placebos Pregnancy Pregnancy Outcome Pregnant Women Prenatal experience prenatal multivitamin supplementation Regression analysis Regression models Risk analysis Risk factors Supplements Tanzania Vitamins Vitamins - therapeutic use Womens health Young Adult |
| title | Multivitamin Supplementation Is Associated with Greater Adequacy of Gestational Weight Gain among Pregnant Women in Tanzania |
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