Otic Organoids Containing Spiral Ganglion Neuron-like Cells Derived from Human-induced Pluripotent Stem Cells as a Model of Drug-induced Neuropathy

Abstract The spiral ganglion of the cochlea is essential for hearing and contains primary bipolar neurons that relay action potentials generated by mechanosensory hair cells. Injury to spiral ganglion neurons (SGNs) causes permanent hearing loss because these cells have limited regenerative capacity...

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Veröffentlicht in:	Stem cells translational medicine 2022-03, Vol.11 (3), p.282-296
Hauptverfasser:	Kurihara, Sho, Fujioka, Masato, Hirabayashi, Motoki, Yoshida, Tomohiko, Hosoya, Makoto, Nagase, Masashi, Kato, Fusao, Ogawa, Kaoru, Okano, Hideyuki, Kojima, Hiromi, Okano, Hirotaka James
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell-Based Drug Development, Screening, and Toxicology Ear, Inner - metabolism Humans Induced Pluripotent Stem Cells Neurons - metabolism Organoids Spiral Ganglion
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