Association of Smoking With Patient Characteristics and Outcomes in Small Cell Lung Carcinoma, 2011-2018
Small cell lung carcinoma (SCLC) is uncommon in individuals who have never smoked (never-smokers). The related epidemiologic factors and prognosis remain unclear. To assess the epidemiologic factors, clinical characteristics, and outcomes of SCLC in never-smokers. A retrospective cohort study was co...
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| Veröffentlicht in: | JAMA network open 2022-03, Vol.5 (3), p.e224830-e224830 |
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| creator | Tseng, Jeng-Sen Chiang, Chun-Ju Chen, Kun-Chieh Zheng, Zhe-Rong Yang, Tsung-Ying Lee, Wen-Chung Hsu, Kuo-Hsuan Huang, Yen-Hsiang Liu, Tsang-Wu Hsia, Jiun-Yi Chang, Gee-Chen |
| description | Small cell lung carcinoma (SCLC) is uncommon in individuals who have never smoked (never-smokers). The related epidemiologic factors and prognosis remain unclear.
To assess the epidemiologic factors, clinical characteristics, and outcomes of SCLC in never-smokers.
A retrospective cohort study was conducted using data from the national Taiwan Cancer Registry, which was inaugurated in 1979 and maintains standardized records of patients' characteristics and clinical information for all individuals with cancer. Patients with cytologically or pathologically proven lung cancer were included for analysis. The study obtained data on patients from January 1, 1996, to December 31, 2018; data analysis was conducted from January 1, 1996, to December 31, 2019.
Clinical characteristics and outcomes of smokers and never-smokers with SCLC.
Clinical characteristics for comparison included age at diagnosis, sex, performance status, tumor stage, and treatment. The main outcome parameter was overall survival of patients with SCLC from 2011 to 2018.
From 1996 to 2018, a total of 225 788 patients had diagnosed lung cancer; 141 654 patients (62.7%) were men; mean (SD) age was 67.55 (12.58) years. The numbers of both patients with newly diagnosed lung cancer and those with SCLC increased until 2009 by 111.5% for lung cancer and 118.5% for SCLC. Thereafter, lung cancer cases grew in number, but SCLC cases did not; hence, the percentage of patients with SCLC decreased from 9.3% in 2009 to 6.3% in 2018. From 2011 to 2018, the percentage of never-smokers increased significantly among all patients with lung cancers (from 49.9% in 2011 to 60.2% in 2018) and among those with lung adenocarcinomas (from 64.1% in 2011 to 70.9% in 2018) (both P |
| doi_str_mv | 10.1001/jamanetworkopen.2022.4830 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8968543</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2665608623</sourcerecordid><originalsourceid>FETCH-LOGICAL-a470t-dae8e52b05515b159360f8b9bb5029a5bb2526c53713b3fb693836c96ff7f4183</originalsourceid><addsrcrecordid>eNpdUV1rHCEUldLShDR_oVj60ofO1o-5rr4UwtAvWEihLX0UdZ2smx3dqpPSf1-HpCENwlX0nHPv8SD0ipIVJYS-25vJRF9_p3ydjj6uGGFs1UtOnqBTBuu-45LA0wfnE3Reyp4QwgjlSsBzdMKhLSrgFO0uSkkumBpSxGnE36Z0HeIV_hnqDn9t1z5WPOxMNq76HEoNrmATt_hyri5NvuAQG8kcDnjwrWzmRh5MdiGmybzFrSftWpEv0LPRHIo_v9vP0I-PH74Pn7vN5acvw8WmM_2a1G5rvPTALAGgYCkoLsgorbIWCFMGrGXAhAO-ptzy0QrFJRdOiXFcjz2V_Ay9v9U9znbyW9fmz-agjzlMJv_RyQT9_0sMO32VbrRUQkLPm8CbO4Gcfs2-VD2F4pq39utpLpqJHnqhhFp6vX4E3ac5x2avoQQIIgVbBNUtyuVUSvbj_TCU6CVS_ShSvUSql0gb9-VDN_fMfwHyvya7oOM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2665608623</pqid></control><display><type>article</type><title>Association of Smoking With Patient Characteristics and Outcomes in Small Cell Lung Carcinoma, 2011-2018</title><source>Electronic Journals Library</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Alma/SFX Local Collection</source><creator>Tseng, Jeng-Sen ; Chiang, Chun-Ju ; Chen, Kun-Chieh ; Zheng, Zhe-Rong ; Yang, Tsung-Ying ; Lee, Wen-Chung ; Hsu, Kuo-Hsuan ; Huang, Yen-Hsiang ; Liu, Tsang-Wu ; Hsia, Jiun-Yi ; Chang, Gee-Chen</creator><creatorcontrib>Tseng, Jeng-Sen ; Chiang, Chun-Ju ; Chen, Kun-Chieh ; Zheng, Zhe-Rong ; Yang, Tsung-Ying ; Lee, Wen-Chung ; Hsu, Kuo-Hsuan ; Huang, Yen-Hsiang ; Liu, Tsang-Wu ; Hsia, Jiun-Yi ; Chang, Gee-Chen</creatorcontrib><description>Small cell lung carcinoma (SCLC) is uncommon in individuals who have never smoked (never-smokers). The related epidemiologic factors and prognosis remain unclear.
To assess the epidemiologic factors, clinical characteristics, and outcomes of SCLC in never-smokers.
A retrospective cohort study was conducted using data from the national Taiwan Cancer Registry, which was inaugurated in 1979 and maintains standardized records of patients' characteristics and clinical information for all individuals with cancer. Patients with cytologically or pathologically proven lung cancer were included for analysis. The study obtained data on patients from January 1, 1996, to December 31, 2018; data analysis was conducted from January 1, 1996, to December 31, 2019.
Clinical characteristics and outcomes of smokers and never-smokers with SCLC.
Clinical characteristics for comparison included age at diagnosis, sex, performance status, tumor stage, and treatment. The main outcome parameter was overall survival of patients with SCLC from 2011 to 2018.
From 1996 to 2018, a total of 225 788 patients had diagnosed lung cancer; 141 654 patients (62.7%) were men; mean (SD) age was 67.55 (12.58) years. The numbers of both patients with newly diagnosed lung cancer and those with SCLC increased until 2009 by 111.5% for lung cancer and 118.5% for SCLC. Thereafter, lung cancer cases grew in number, but SCLC cases did not; hence, the percentage of patients with SCLC decreased from 9.3% in 2009 to 6.3% in 2018. From 2011 to 2018, the percentage of never-smokers increased significantly among all patients with lung cancers (from 49.9% in 2011 to 60.2% in 2018) and among those with lung adenocarcinomas (from 64.1% in 2011 to 70.9% in 2018) (both P < .001). However, the percentage of never-smokers appeared to vary little in the SCLC population: 15.5% in 2011 and 16.1% in 2018 (P = .28). The median overall survival was significantly longer in patients with adenocarcinoma vs SCLC (adjusted hazard ratio, 0.32; 95% CI, 0.31-0.33; P < .001). Compared with smokers with SCLC, never-smokers with SCLC tended to include more older patients (age ≥70 years: 492 [57.3%] vs 2242 [44.8%]), more women (274 [31.9%] vs 322 [6.4%]), more individuals with a poor performance status (Eastern Cooperative Oncology Group performance status ≥2: 284 [33.1%] vs 1261 [25.2%]) and stage IV cancer (660 [76.9%] vs 3590 [71.8%]), and more patients without treatment (203 [23.7%] vs 626 [12.5%]). Furthermore, never-smokers, particularly men, experienced a shorter survival rate (adjusted hazard ratio, 1.10; 95% CI, 1.00-1.20; P = .04) compared with the other groups.
The findings of this cohort study suggest that the decrease in the percentage of patients with SCLC was associated with increased lung cancers of other histologic types, with no substantial decrease in the number of those with SCLC.</description><identifier>ISSN: 2574-3805</identifier><identifier>EISSN: 2574-3805</identifier><identifier>DOI: 10.1001/jamanetworkopen.2022.4830</identifier><identifier>PMID: 35353165</identifier><language>eng</language><publisher>United States: American Medical Association</publisher><subject>Aged ; Aged, 80 and over ; Cohort Studies ; Female ; Humans ; Lung cancer ; Lung Neoplasms ; Male ; Medical prognosis ; Middle Aged ; Oncology ; Online Only ; Original Investigation ; Retrospective Studies ; Small Cell Lung Carcinoma - drug therapy ; Small Cell Lung Carcinoma - therapy ; Smoking - adverse effects ; Smoking - epidemiology</subject><ispartof>JAMA network open, 2022-03, Vol.5 (3), p.e224830-e224830</ispartof><rights>2022. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright 2022 Tseng JS et al. .</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a470t-dae8e52b05515b159360f8b9bb5029a5bb2526c53713b3fb693836c96ff7f4183</citedby><cites>FETCH-LOGICAL-a470t-dae8e52b05515b159360f8b9bb5029a5bb2526c53713b3fb693836c96ff7f4183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,860,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35353165$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tseng, Jeng-Sen</creatorcontrib><creatorcontrib>Chiang, Chun-Ju</creatorcontrib><creatorcontrib>Chen, Kun-Chieh</creatorcontrib><creatorcontrib>Zheng, Zhe-Rong</creatorcontrib><creatorcontrib>Yang, Tsung-Ying</creatorcontrib><creatorcontrib>Lee, Wen-Chung</creatorcontrib><creatorcontrib>Hsu, Kuo-Hsuan</creatorcontrib><creatorcontrib>Huang, Yen-Hsiang</creatorcontrib><creatorcontrib>Liu, Tsang-Wu</creatorcontrib><creatorcontrib>Hsia, Jiun-Yi</creatorcontrib><creatorcontrib>Chang, Gee-Chen</creatorcontrib><title>Association of Smoking With Patient Characteristics and Outcomes in Small Cell Lung Carcinoma, 2011-2018</title><title>JAMA network open</title><addtitle>JAMA Netw Open</addtitle><description>Small cell lung carcinoma (SCLC) is uncommon in individuals who have never smoked (never-smokers). The related epidemiologic factors and prognosis remain unclear.
To assess the epidemiologic factors, clinical characteristics, and outcomes of SCLC in never-smokers.
A retrospective cohort study was conducted using data from the national Taiwan Cancer Registry, which was inaugurated in 1979 and maintains standardized records of patients' characteristics and clinical information for all individuals with cancer. Patients with cytologically or pathologically proven lung cancer were included for analysis. The study obtained data on patients from January 1, 1996, to December 31, 2018; data analysis was conducted from January 1, 1996, to December 31, 2019.
Clinical characteristics and outcomes of smokers and never-smokers with SCLC.
Clinical characteristics for comparison included age at diagnosis, sex, performance status, tumor stage, and treatment. The main outcome parameter was overall survival of patients with SCLC from 2011 to 2018.
From 1996 to 2018, a total of 225 788 patients had diagnosed lung cancer; 141 654 patients (62.7%) were men; mean (SD) age was 67.55 (12.58) years. The numbers of both patients with newly diagnosed lung cancer and those with SCLC increased until 2009 by 111.5% for lung cancer and 118.5% for SCLC. Thereafter, lung cancer cases grew in number, but SCLC cases did not; hence, the percentage of patients with SCLC decreased from 9.3% in 2009 to 6.3% in 2018. From 2011 to 2018, the percentage of never-smokers increased significantly among all patients with lung cancers (from 49.9% in 2011 to 60.2% in 2018) and among those with lung adenocarcinomas (from 64.1% in 2011 to 70.9% in 2018) (both P < .001). However, the percentage of never-smokers appeared to vary little in the SCLC population: 15.5% in 2011 and 16.1% in 2018 (P = .28). The median overall survival was significantly longer in patients with adenocarcinoma vs SCLC (adjusted hazard ratio, 0.32; 95% CI, 0.31-0.33; P < .001). Compared with smokers with SCLC, never-smokers with SCLC tended to include more older patients (age ≥70 years: 492 [57.3%] vs 2242 [44.8%]), more women (274 [31.9%] vs 322 [6.4%]), more individuals with a poor performance status (Eastern Cooperative Oncology Group performance status ≥2: 284 [33.1%] vs 1261 [25.2%]) and stage IV cancer (660 [76.9%] vs 3590 [71.8%]), and more patients without treatment (203 [23.7%] vs 626 [12.5%]). Furthermore, never-smokers, particularly men, experienced a shorter survival rate (adjusted hazard ratio, 1.10; 95% CI, 1.00-1.20; P = .04) compared with the other groups.
The findings of this cohort study suggest that the decrease in the percentage of patients with SCLC was associated with increased lung cancers of other histologic types, with no substantial decrease in the number of those with SCLC.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>Lung Neoplasms</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Online Only</subject><subject>Original Investigation</subject><subject>Retrospective Studies</subject><subject>Small Cell Lung Carcinoma - drug therapy</subject><subject>Small Cell Lung Carcinoma - therapy</subject><subject>Smoking - adverse effects</subject><subject>Smoking - epidemiology</subject><issn>2574-3805</issn><issn>2574-3805</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdUV1rHCEUldLShDR_oVj60ofO1o-5rr4UwtAvWEihLX0UdZ2smx3dqpPSf1-HpCENwlX0nHPv8SD0ipIVJYS-25vJRF9_p3ydjj6uGGFs1UtOnqBTBuu-45LA0wfnE3Reyp4QwgjlSsBzdMKhLSrgFO0uSkkumBpSxGnE36Z0HeIV_hnqDn9t1z5WPOxMNq76HEoNrmATt_hyri5NvuAQG8kcDnjwrWzmRh5MdiGmybzFrSftWpEv0LPRHIo_v9vP0I-PH74Pn7vN5acvw8WmM_2a1G5rvPTALAGgYCkoLsgorbIWCFMGrGXAhAO-ptzy0QrFJRdOiXFcjz2V_Ay9v9U9znbyW9fmz-agjzlMJv_RyQT9_0sMO32VbrRUQkLPm8CbO4Gcfs2-VD2F4pq39utpLpqJHnqhhFp6vX4E3ac5x2avoQQIIgVbBNUtyuVUSvbj_TCU6CVS_ShSvUSql0gb9-VDN_fMfwHyvya7oOM</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Tseng, Jeng-Sen</creator><creator>Chiang, Chun-Ju</creator><creator>Chen, Kun-Chieh</creator><creator>Zheng, Zhe-Rong</creator><creator>Yang, Tsung-Ying</creator><creator>Lee, Wen-Chung</creator><creator>Hsu, Kuo-Hsuan</creator><creator>Huang, Yen-Hsiang</creator><creator>Liu, Tsang-Wu</creator><creator>Hsia, Jiun-Yi</creator><creator>Chang, Gee-Chen</creator><general>American Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220301</creationdate><title>Association of Smoking With Patient Characteristics and Outcomes in Small Cell Lung Carcinoma, 2011-2018</title><author>Tseng, Jeng-Sen ; Chiang, Chun-Ju ; Chen, Kun-Chieh ; Zheng, Zhe-Rong ; Yang, Tsung-Ying ; Lee, Wen-Chung ; Hsu, Kuo-Hsuan ; Huang, Yen-Hsiang ; Liu, Tsang-Wu ; Hsia, Jiun-Yi ; Chang, Gee-Chen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a470t-dae8e52b05515b159360f8b9bb5029a5bb2526c53713b3fb693836c96ff7f4183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Lung cancer</topic><topic>Lung Neoplasms</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Online Only</topic><topic>Original Investigation</topic><topic>Retrospective Studies</topic><topic>Small Cell Lung Carcinoma - drug therapy</topic><topic>Small Cell Lung Carcinoma - therapy</topic><topic>Smoking - adverse effects</topic><topic>Smoking - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tseng, Jeng-Sen</creatorcontrib><creatorcontrib>Chiang, Chun-Ju</creatorcontrib><creatorcontrib>Chen, Kun-Chieh</creatorcontrib><creatorcontrib>Zheng, Zhe-Rong</creatorcontrib><creatorcontrib>Yang, Tsung-Ying</creatorcontrib><creatorcontrib>Lee, Wen-Chung</creatorcontrib><creatorcontrib>Hsu, Kuo-Hsuan</creatorcontrib><creatorcontrib>Huang, Yen-Hsiang</creatorcontrib><creatorcontrib>Liu, Tsang-Wu</creatorcontrib><creatorcontrib>Hsia, Jiun-Yi</creatorcontrib><creatorcontrib>Chang, Gee-Chen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JAMA network open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tseng, Jeng-Sen</au><au>Chiang, Chun-Ju</au><au>Chen, Kun-Chieh</au><au>Zheng, Zhe-Rong</au><au>Yang, Tsung-Ying</au><au>Lee, Wen-Chung</au><au>Hsu, Kuo-Hsuan</au><au>Huang, Yen-Hsiang</au><au>Liu, Tsang-Wu</au><au>Hsia, Jiun-Yi</au><au>Chang, Gee-Chen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Smoking With Patient Characteristics and Outcomes in Small Cell Lung Carcinoma, 2011-2018</atitle><jtitle>JAMA network open</jtitle><addtitle>JAMA Netw Open</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>5</volume><issue>3</issue><spage>e224830</spage><epage>e224830</epage><pages>e224830-e224830</pages><issn>2574-3805</issn><eissn>2574-3805</eissn><abstract>Small cell lung carcinoma (SCLC) is uncommon in individuals who have never smoked (never-smokers). The related epidemiologic factors and prognosis remain unclear.
To assess the epidemiologic factors, clinical characteristics, and outcomes of SCLC in never-smokers.
A retrospective cohort study was conducted using data from the national Taiwan Cancer Registry, which was inaugurated in 1979 and maintains standardized records of patients' characteristics and clinical information for all individuals with cancer. Patients with cytologically or pathologically proven lung cancer were included for analysis. The study obtained data on patients from January 1, 1996, to December 31, 2018; data analysis was conducted from January 1, 1996, to December 31, 2019.
Clinical characteristics and outcomes of smokers and never-smokers with SCLC.
Clinical characteristics for comparison included age at diagnosis, sex, performance status, tumor stage, and treatment. The main outcome parameter was overall survival of patients with SCLC from 2011 to 2018.
From 1996 to 2018, a total of 225 788 patients had diagnosed lung cancer; 141 654 patients (62.7%) were men; mean (SD) age was 67.55 (12.58) years. The numbers of both patients with newly diagnosed lung cancer and those with SCLC increased until 2009 by 111.5% for lung cancer and 118.5% for SCLC. Thereafter, lung cancer cases grew in number, but SCLC cases did not; hence, the percentage of patients with SCLC decreased from 9.3% in 2009 to 6.3% in 2018. From 2011 to 2018, the percentage of never-smokers increased significantly among all patients with lung cancers (from 49.9% in 2011 to 60.2% in 2018) and among those with lung adenocarcinomas (from 64.1% in 2011 to 70.9% in 2018) (both P < .001). However, the percentage of never-smokers appeared to vary little in the SCLC population: 15.5% in 2011 and 16.1% in 2018 (P = .28). The median overall survival was significantly longer in patients with adenocarcinoma vs SCLC (adjusted hazard ratio, 0.32; 95% CI, 0.31-0.33; P < .001). Compared with smokers with SCLC, never-smokers with SCLC tended to include more older patients (age ≥70 years: 492 [57.3%] vs 2242 [44.8%]), more women (274 [31.9%] vs 322 [6.4%]), more individuals with a poor performance status (Eastern Cooperative Oncology Group performance status ≥2: 284 [33.1%] vs 1261 [25.2%]) and stage IV cancer (660 [76.9%] vs 3590 [71.8%]), and more patients without treatment (203 [23.7%] vs 626 [12.5%]). Furthermore, never-smokers, particularly men, experienced a shorter survival rate (adjusted hazard ratio, 1.10; 95% CI, 1.00-1.20; P = .04) compared with the other groups.
The findings of this cohort study suggest that the decrease in the percentage of patients with SCLC was associated with increased lung cancers of other histologic types, with no substantial decrease in the number of those with SCLC.</abstract><cop>United States</cop><pub>American Medical Association</pub><pmid>35353165</pmid><doi>10.1001/jamanetworkopen.2022.4830</doi><oa>free_for_read</oa></addata></record> |
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| source | Electronic Journals Library; MEDLINE; DOAJ Directory of Open Access Journals; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Cohort Studies Female Humans Lung cancer Lung Neoplasms Male Medical prognosis Middle Aged Oncology Online Only Original Investigation Retrospective Studies Small Cell Lung Carcinoma - drug therapy Small Cell Lung Carcinoma - therapy Smoking - adverse effects Smoking - epidemiology |
| title | Association of Smoking With Patient Characteristics and Outcomes in Small Cell Lung Carcinoma, 2011-2018 |
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