The Relationship of Kidney Tubule Biomarkers with Brain Imaging in CKD Patients in SPRINT
Urine biomarker concentrations reflecting kidney tubule injury and dysfunction were not associated with brain MRI measures.Higher eGFR was associated with lower total brain cerebral blood flow.This is the first evaluation of the relationship of kidney tubule biomarkers with brain imaging by MRI in p...
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Veröffentlicht in: | Kidney360 2022-02, Vol.3 (2), p.337-340 |
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description | Urine biomarker concentrations reflecting kidney tubule injury and dysfunction were not associated with brain MRI measures.Higher eGFR was associated with lower total brain cerebral blood flow.This is the first evaluation of the relationship of kidney tubule biomarkers with brain imaging by MRI in patients with CKD. |
doi_str_mv | 10.34067/KID.0007702021 |
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Kurella Tamura, Manjula ; Pajewski, Nicholas M ; Rifkin, Dena ; Weiner, Daniel ; Marquine, Maria ; Shlipak, Michael G ; Ix, Joachim H</creator><creatorcontrib>Miller, Lindsay M ; Kurella Tamura, Manjula ; Pajewski, Nicholas M ; Rifkin, Dena ; Weiner, Daniel ; Marquine, Maria ; Shlipak, Michael G ; Ix, Joachim H</creatorcontrib><description>Urine biomarker concentrations reflecting kidney tubule injury and dysfunction were not associated with brain MRI measures.Higher eGFR was associated with lower total brain cerebral blood flow.This is the first evaluation of the relationship of kidney tubule biomarkers with brain imaging by MRI in patients with CKD.</description><identifier>ISSN: 2641-7650</identifier><identifier>EISSN: 2641-7650</identifier><identifier>DOI: 10.34067/KID.0007702021</identifier><identifier>PMID: 35373134</identifier><language>eng</language><publisher>United States: American Society of Nephrology</publisher><subject>Biomarkers ; Brain - diagnostic imaging ; Brief Communication ; Glomerular Filtration Rate - physiology ; Humans ; Kidney Tubules - injuries ; Neuroimaging ; Renal Insufficiency, Chronic - diagnostic imaging</subject><ispartof>Kidney360, 2022-02, Vol.3 (2), p.337-340</ispartof><rights>Copyright © 2022 by the American Society of Nephrology.</rights><rights>Copyright © 2022 by the American Society of Nephrology 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-728f545126dd17d9e2ceece67aeeb671b744cf5ac4f37146432bb0eebc01b5ec3</citedby><cites>FETCH-LOGICAL-c393t-728f545126dd17d9e2ceece67aeeb671b744cf5ac4f37146432bb0eebc01b5ec3</cites><orcidid>0000-0001-5227-2479 ; 0000-0002-8775-394 ; 0000-0001-7404-4725 ; 0000-0002-4447-6196 ; 0000-0002-8775-394X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967647/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967647/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35373134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller, Lindsay M</creatorcontrib><creatorcontrib>Kurella Tamura, Manjula</creatorcontrib><creatorcontrib>Pajewski, Nicholas M</creatorcontrib><creatorcontrib>Rifkin, Dena</creatorcontrib><creatorcontrib>Weiner, Daniel</creatorcontrib><creatorcontrib>Marquine, Maria</creatorcontrib><creatorcontrib>Shlipak, Michael G</creatorcontrib><creatorcontrib>Ix, Joachim H</creatorcontrib><title>The Relationship of Kidney Tubule Biomarkers with Brain Imaging in CKD Patients in SPRINT</title><title>Kidney360</title><addtitle>Kidney360</addtitle><description>Urine biomarker concentrations reflecting kidney tubule injury and dysfunction were not associated with brain MRI measures.Higher eGFR was associated with lower total brain cerebral blood flow.This is the first evaluation of the relationship of kidney tubule biomarkers with brain imaging by MRI in patients with CKD.</description><subject>Biomarkers</subject><subject>Brain - diagnostic imaging</subject><subject>Brief Communication</subject><subject>Glomerular Filtration Rate - physiology</subject><subject>Humans</subject><subject>Kidney Tubules - injuries</subject><subject>Neuroimaging</subject><subject>Renal Insufficiency, Chronic - diagnostic imaging</subject><issn>2641-7650</issn><issn>2641-7650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUctOwzAQtBAIKuiZG_KRS8Gv2M0FiZZX1AoQlAMny3E2rSFNSpyA-vcYCqWcdlczOzvaQeiQkhMuiFSno-TihBCiFGGE0S3UYVLQnpIR2d7o91DX-5fAYzFjfS530R6PuOKUiw56nswAP0BhGleVfuYWuMrxyGUlLPGkTdsC8MBVc1O_Qu3xh2tmeFAbV-JkbqaunOLQDkcX-D4IQNn4r_nx_iG5nRygndwUHro_dR89XV1Ohje98d11Mjwf9yyPedNTrJ9HIqJMZhlVWQzMAliQygCkUtFUCWHzyFiRc0WFFJylKQmYJTSNwPJ9dLbSXbTpHDIbXNSm0IvaBddLXRmn_yOlm-lp9a77sVRSqCBw_CNQV28t-EbPnbdQFKaEqvU6PFLGgquYB-rpimrryvsa8vUZSvR3Jjpkov8yCRtHm-7W_N8E-CdGK4d5</recordid><startdate>20220224</startdate><enddate>20220224</enddate><creator>Miller, Lindsay M</creator><creator>Kurella Tamura, Manjula</creator><creator>Pajewski, Nicholas M</creator><creator>Rifkin, Dena</creator><creator>Weiner, Daniel</creator><creator>Marquine, Maria</creator><creator>Shlipak, Michael G</creator><creator>Ix, Joachim H</creator><general>American Society of Nephrology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5227-2479</orcidid><orcidid>https://orcid.org/0000-0002-8775-394</orcidid><orcidid>https://orcid.org/0000-0001-7404-4725</orcidid><orcidid>https://orcid.org/0000-0002-4447-6196</orcidid><orcidid>https://orcid.org/0000-0002-8775-394X</orcidid></search><sort><creationdate>20220224</creationdate><title>The Relationship of Kidney Tubule Biomarkers with Brain Imaging in CKD Patients in SPRINT</title><author>Miller, Lindsay M ; 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subjects | Biomarkers Brain - diagnostic imaging Brief Communication Glomerular Filtration Rate - physiology Humans Kidney Tubules - injuries Neuroimaging Renal Insufficiency, Chronic - diagnostic imaging |
title | The Relationship of Kidney Tubule Biomarkers with Brain Imaging in CKD Patients in SPRINT |
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