Albuminuria within the Normal Range Can Predict All-Cause Mortality and Cardiovascular Mortality

Despite interest in low-grade albuminuria and poor clinical outcomes, evidence from a large-scale population is lacking. Therefore, we identified the association of low-grade albuminuria within the normal range with all-cause and cardiovascular (CV) mortality. After excluding individuals with urine...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Kidney360 2022-01, Vol.3 (1), p.74-82
Hauptverfasser:	Kang, Minjung, Kwon, Soie, Lee, Jeonghwan, Shin, Jung-Im, Kim, Yong Chul, Park, Jae Yoon, Bae, Eunjin, Kim, Eun Young, Kim, Dong Ki, Lim, Chun Soo, Lee, Jung Pyo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Albuminuria - etiology Cardiovascular Diseases - epidemiology Cohort Studies Creatinine - urine Humans Nutrition Surveys Original Investigation Reference Values
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	82
container_issue	1
container_start_page	74
container_title	Kidney360
container_volume	3
creator	Kang, Minjung Kwon, Soie Lee, Jeonghwan Shin, Jung-Im Kim, Yong Chul Park, Jae Yoon Bae, Eunjin Kim, Eun Young Kim, Dong Ki Lim, Chun Soo Lee, Jung Pyo
description	Despite interest in low-grade albuminuria and poor clinical outcomes, evidence from a large-scale population is lacking. Therefore, we identified the association of low-grade albuminuria within the normal range with all-cause and cardiovascular (CV) mortality. After excluding individuals with urine albumin-creatinine ratio (ACR) ≥30 mg/g ( =6094), this cohort study analyzed 43,396 adults who participated in the National Health and Nutrition Examination Survey (1999-2016). Participants were divided into four quartiles of ACR. The primary outcome was all-cause mortality, and the secondary outcome was CV mortality. Multivariable Cox proportional hazards models were used. During a median 7.9 years of follow-up, 3516 (9%) participants died. Compared with the reference group (Q1, ACR
doi_str_mv	10.34067/KID.0003912021
format	Article
fullrecord	<record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8967601</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2646946452</sourcerecordid><originalsourceid>FETCH-LOGICAL-c459t-c5d21ca5babc75d96dbfc02c2f5c14f9e792559c6dfe8c21d061825ea4725b473</originalsourceid><addsrcrecordid>eNpVkctLxDAQxoMoKurZm-TopWuSNklzEZb1iU9Ez3GapG4kbTVplf3vLT7X0wx8v_lmmA-hXUomeUGEPLg4P5oQQnJFGWF0BW0yUdBMCk5Wl_oNtJPS88gxxViZi3W0kfNclFzKTfQ4DdXQ-HaIHvC77-e-xf3c4esuNhDwHbRPDs-gxbfRWW96PA0hm8GQHL7qYg_B9wsMrR2ZaH33BskMAeKfuI3WagjJ7XzXLfRwcnw_O8sub07PZ9PLzBRc9ZnhllEDvILKSG6VsFVtCDOs5oYWtXJSMc6VEbZ2pWHUEkFLxh0UkvGqkPkWOvzyfRmqxlnj2j5C0C_RNxAXugOv_yutn-un7k2XSkhB6Giw_20Qu9fBpV43PhkXArSuG5Ie_ylUIQrORvTgCzWxSym6-ncNJfozGj1Go_-iGSf2lq_75X-CyD8AR26LSA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2646946452</pqid></control><display><type>article</type><title>Albuminuria within the Normal Range Can Predict All-Cause Mortality and Cardiovascular Mortality</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central</source><creator>Kang, Minjung ; Kwon, Soie ; Lee, Jeonghwan ; Shin, Jung-Im ; Kim, Yong Chul ; Park, Jae Yoon ; Bae, Eunjin ; Kim, Eun Young ; Kim, Dong Ki ; Lim, Chun Soo ; Lee, Jung Pyo</creator><creatorcontrib>Kang, Minjung ; Kwon, Soie ; Lee, Jeonghwan ; Shin, Jung-Im ; Kim, Yong Chul ; Park, Jae Yoon ; Bae, Eunjin ; Kim, Eun Young ; Kim, Dong Ki ; Lim, Chun Soo ; Lee, Jung Pyo</creatorcontrib><description>Despite interest in low-grade albuminuria and poor clinical outcomes, evidence from a large-scale population is lacking. Therefore, we identified the association of low-grade albuminuria within the normal range with all-cause and cardiovascular (CV) mortality. After excluding individuals with urine albumin-creatinine ratio (ACR) ≥30 mg/g ( =6094), this cohort study analyzed 43,396 adults who participated in the National Health and Nutrition Examination Survey (1999-2016). Participants were divided into four quartiles of ACR. The primary outcome was all-cause mortality, and the secondary outcome was CV mortality. Multivariable Cox proportional hazards models were used. During a median 7.9 years of follow-up, 3516 (9%) participants died. Compared with the reference group (Q1, ACR <4.171 mg/g), low-grade albuminuria groups were associated with all-cause mortality (Q3, ACR ≥6.211 to <10.010 mg/g, hazard ratio [HR], 1.25 [95% CI, 1.11 to 1.41]; Q4, ACR ≥10.010 mg/g, HR, 1.57 [95% CI, 1.41 to 1.76]) in a multivariable hazards model. A similar pattern was also seen in the association of low-grade albuminuria with CV mortality. Subgroup analyses showed that low-grade albuminuria was also associated with all-cause mortality in the nondiabetic group, nonhypertensive group, and non-CKD group (eGFR ≥60 ml/min per 1.73 m ). Our findings suggest that low-grade albuminuria is associated with all-cause and CV mortality. Low-grade albuminuria should be monitored, even for patients with low CV risk.</description><identifier>ISSN: 2641-7650</identifier><identifier>EISSN: 2641-7650</identifier><identifier>DOI: 10.34067/KID.0003912021</identifier><identifier>PMID: 35368577</identifier><language>eng</language><publisher>United States: American Society of Nephrology</publisher><subject>Adult ; Albuminuria - etiology ; Cardiovascular Diseases - epidemiology ; Cohort Studies ; Creatinine - urine ; Humans ; Nutrition Surveys ; Original Investigation ; Reference Values</subject><ispartof>Kidney360, 2022-01, Vol.3 (1), p.74-82</ispartof><rights>Copyright © 2022 by the American Society of Nephrology.</rights><rights>Copyright © 2022 by the American Society of Nephrology 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-c5d21ca5babc75d96dbfc02c2f5c14f9e792559c6dfe8c21d061825ea4725b473</citedby><cites>FETCH-LOGICAL-c459t-c5d21ca5babc75d96dbfc02c2f5c14f9e792559c6dfe8c21d061825ea4725b473</cites><orcidid>0000-0003-3960-7005 ; 0000-0003-3215-8681 ; 0000-0002-5195-7852 ; 0000-0002-2788-6839 ; 0000-0002-4714-1260 ; 0000-0002-0878-5469 ; 0000-0003-3199-635 ; 0000-0003-3199-635X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967601/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967601/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35368577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Minjung</creatorcontrib><creatorcontrib>Kwon, Soie</creatorcontrib><creatorcontrib>Lee, Jeonghwan</creatorcontrib><creatorcontrib>Shin, Jung-Im</creatorcontrib><creatorcontrib>Kim, Yong Chul</creatorcontrib><creatorcontrib>Park, Jae Yoon</creatorcontrib><creatorcontrib>Bae, Eunjin</creatorcontrib><creatorcontrib>Kim, Eun Young</creatorcontrib><creatorcontrib>Kim, Dong Ki</creatorcontrib><creatorcontrib>Lim, Chun Soo</creatorcontrib><creatorcontrib>Lee, Jung Pyo</creatorcontrib><title>Albuminuria within the Normal Range Can Predict All-Cause Mortality and Cardiovascular Mortality</title><title>Kidney360</title><addtitle>Kidney360</addtitle><description>Despite interest in low-grade albuminuria and poor clinical outcomes, evidence from a large-scale population is lacking. Therefore, we identified the association of low-grade albuminuria within the normal range with all-cause and cardiovascular (CV) mortality. After excluding individuals with urine albumin-creatinine ratio (ACR) ≥30 mg/g ( =6094), this cohort study analyzed 43,396 adults who participated in the National Health and Nutrition Examination Survey (1999-2016). Participants were divided into four quartiles of ACR. The primary outcome was all-cause mortality, and the secondary outcome was CV mortality. Multivariable Cox proportional hazards models were used. During a median 7.9 years of follow-up, 3516 (9%) participants died. Compared with the reference group (Q1, ACR <4.171 mg/g), low-grade albuminuria groups were associated with all-cause mortality (Q3, ACR ≥6.211 to <10.010 mg/g, hazard ratio [HR], 1.25 [95% CI, 1.11 to 1.41]; Q4, ACR ≥10.010 mg/g, HR, 1.57 [95% CI, 1.41 to 1.76]) in a multivariable hazards model. A similar pattern was also seen in the association of low-grade albuminuria with CV mortality. Subgroup analyses showed that low-grade albuminuria was also associated with all-cause mortality in the nondiabetic group, nonhypertensive group, and non-CKD group (eGFR ≥60 ml/min per 1.73 m ). Our findings suggest that low-grade albuminuria is associated with all-cause and CV mortality. Low-grade albuminuria should be monitored, even for patients with low CV risk.</description><subject>Adult</subject><subject>Albuminuria - etiology</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cohort Studies</subject><subject>Creatinine - urine</subject><subject>Humans</subject><subject>Nutrition Surveys</subject><subject>Original Investigation</subject><subject>Reference Values</subject><issn>2641-7650</issn><issn>2641-7650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkctLxDAQxoMoKurZm-TopWuSNklzEZb1iU9Ez3GapG4kbTVplf3vLT7X0wx8v_lmmA-hXUomeUGEPLg4P5oQQnJFGWF0BW0yUdBMCk5Wl_oNtJPS88gxxViZi3W0kfNclFzKTfQ4DdXQ-HaIHvC77-e-xf3c4esuNhDwHbRPDs-gxbfRWW96PA0hm8GQHL7qYg_B9wsMrR2ZaH33BskMAeKfuI3WagjJ7XzXLfRwcnw_O8sub07PZ9PLzBRc9ZnhllEDvILKSG6VsFVtCDOs5oYWtXJSMc6VEbZ2pWHUEkFLxh0UkvGqkPkWOvzyfRmqxlnj2j5C0C_RNxAXugOv_yutn-un7k2XSkhB6Giw_20Qu9fBpV43PhkXArSuG5Ie_ylUIQrORvTgCzWxSym6-ncNJfozGj1Go_-iGSf2lq_75X-CyD8AR26LSA</recordid><startdate>20220127</startdate><enddate>20220127</enddate><creator>Kang, Minjung</creator><creator>Kwon, Soie</creator><creator>Lee, Jeonghwan</creator><creator>Shin, Jung-Im</creator><creator>Kim, Yong Chul</creator><creator>Park, Jae Yoon</creator><creator>Bae, Eunjin</creator><creator>Kim, Eun Young</creator><creator>Kim, Dong Ki</creator><creator>Lim, Chun Soo</creator><creator>Lee, Jung Pyo</creator><general>American Society of Nephrology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3960-7005</orcidid><orcidid>https://orcid.org/0000-0003-3215-8681</orcidid><orcidid>https://orcid.org/0000-0002-5195-7852</orcidid><orcidid>https://orcid.org/0000-0002-2788-6839</orcidid><orcidid>https://orcid.org/0000-0002-4714-1260</orcidid><orcidid>https://orcid.org/0000-0002-0878-5469</orcidid><orcidid>https://orcid.org/0000-0003-3199-635</orcidid><orcidid>https://orcid.org/0000-0003-3199-635X</orcidid></search><sort><creationdate>20220127</creationdate><title>Albuminuria within the Normal Range Can Predict All-Cause Mortality and Cardiovascular Mortality</title><author>Kang, Minjung ; Kwon, Soie ; Lee, Jeonghwan ; Shin, Jung-Im ; Kim, Yong Chul ; Park, Jae Yoon ; Bae, Eunjin ; Kim, Eun Young ; Kim, Dong Ki ; Lim, Chun Soo ; Lee, Jung Pyo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-c5d21ca5babc75d96dbfc02c2f5c14f9e792559c6dfe8c21d061825ea4725b473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Albuminuria - etiology</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cohort Studies</topic><topic>Creatinine - urine</topic><topic>Humans</topic><topic>Nutrition Surveys</topic><topic>Original Investigation</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Minjung</creatorcontrib><creatorcontrib>Kwon, Soie</creatorcontrib><creatorcontrib>Lee, Jeonghwan</creatorcontrib><creatorcontrib>Shin, Jung-Im</creatorcontrib><creatorcontrib>Kim, Yong Chul</creatorcontrib><creatorcontrib>Park, Jae Yoon</creatorcontrib><creatorcontrib>Bae, Eunjin</creatorcontrib><creatorcontrib>Kim, Eun Young</creatorcontrib><creatorcontrib>Kim, Dong Ki</creatorcontrib><creatorcontrib>Lim, Chun Soo</creatorcontrib><creatorcontrib>Lee, Jung Pyo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Kidney360</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Minjung</au><au>Kwon, Soie</au><au>Lee, Jeonghwan</au><au>Shin, Jung-Im</au><au>Kim, Yong Chul</au><au>Park, Jae Yoon</au><au>Bae, Eunjin</au><au>Kim, Eun Young</au><au>Kim, Dong Ki</au><au>Lim, Chun Soo</au><au>Lee, Jung Pyo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Albuminuria within the Normal Range Can Predict All-Cause Mortality and Cardiovascular Mortality</atitle><jtitle>Kidney360</jtitle><addtitle>Kidney360</addtitle><date>2022-01-27</date><risdate>2022</risdate><volume>3</volume><issue>1</issue><spage>74</spage><epage>82</epage><pages>74-82</pages><issn>2641-7650</issn><eissn>2641-7650</eissn><abstract>Despite interest in low-grade albuminuria and poor clinical outcomes, evidence from a large-scale population is lacking. Therefore, we identified the association of low-grade albuminuria within the normal range with all-cause and cardiovascular (CV) mortality. After excluding individuals with urine albumin-creatinine ratio (ACR) ≥30 mg/g ( =6094), this cohort study analyzed 43,396 adults who participated in the National Health and Nutrition Examination Survey (1999-2016). Participants were divided into four quartiles of ACR. The primary outcome was all-cause mortality, and the secondary outcome was CV mortality. Multivariable Cox proportional hazards models were used. During a median 7.9 years of follow-up, 3516 (9%) participants died. Compared with the reference group (Q1, ACR <4.171 mg/g), low-grade albuminuria groups were associated with all-cause mortality (Q3, ACR ≥6.211 to <10.010 mg/g, hazard ratio [HR], 1.25 [95% CI, 1.11 to 1.41]; Q4, ACR ≥10.010 mg/g, HR, 1.57 [95% CI, 1.41 to 1.76]) in a multivariable hazards model. A similar pattern was also seen in the association of low-grade albuminuria with CV mortality. Subgroup analyses showed that low-grade albuminuria was also associated with all-cause mortality in the nondiabetic group, nonhypertensive group, and non-CKD group (eGFR ≥60 ml/min per 1.73 m ). Our findings suggest that low-grade albuminuria is associated with all-cause and CV mortality. Low-grade albuminuria should be monitored, even for patients with low CV risk.</abstract><cop>United States</cop><pub>American Society of Nephrology</pub><pmid>35368577</pmid><doi>10.34067/KID.0003912021</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3960-7005</orcidid><orcidid>https://orcid.org/0000-0003-3215-8681</orcidid><orcidid>https://orcid.org/0000-0002-5195-7852</orcidid><orcidid>https://orcid.org/0000-0002-2788-6839</orcidid><orcidid>https://orcid.org/0000-0002-4714-1260</orcidid><orcidid>https://orcid.org/0000-0002-0878-5469</orcidid><orcidid>https://orcid.org/0000-0003-3199-635</orcidid><orcidid>https://orcid.org/0000-0003-3199-635X</orcidid><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 2641-7650
ispartof	Kidney360, 2022-01, Vol.3 (1), p.74-82
issn	2641-7650 2641-7650
language	eng
recordid	cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8967601
source	MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central
subjects	Adult Albuminuria - etiology Cardiovascular Diseases - epidemiology Cohort Studies Creatinine - urine Humans Nutrition Surveys Original Investigation Reference Values
title	Albuminuria within the Normal Range Can Predict All-Cause Mortality and Cardiovascular Mortality
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T11%3A19%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Albuminuria%20within%20the%20Normal%20Range%20Can%20Predict%20All-Cause%20Mortality%20and%20Cardiovascular%20Mortality&rft.jtitle=Kidney360&rft.au=Kang,%20Minjung&rft.date=2022-01-27&rft.volume=3&rft.issue=1&rft.spage=74&rft.epage=82&rft.pages=74-82&rft.issn=2641-7650&rft.eissn=2641-7650&rft_id=info:doi/10.34067/KID.0003912021&rft_dat=%3Cproquest_pubme%3E2646946452%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2646946452&rft_id=info:pmid/35368577&rfr_iscdi=true