Comparison of natural and artificial cycles in frozen-thawed embryo transfer: A retrospective analysis of 1696 cycles
This study aimed to compare the pregnancy outcomes of natural cycles (NC) and artificial cycles (AC) in patients undergoing endometrial preparation for frozen-thawed embryo transfer (FET). This retrospective cohort study was conducted in a private infertility clinic between September 2016 and Januar...
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| Veröffentlicht in: | Turkish journal of obstetrics and gynecology 2022-03, Vol.19 (1), p.28-34 |
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| container_title | Turkish journal of obstetrics and gynecology |
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| creator | Demirdağ, Erhan Güler, İsmail Cevher Akdulum, Münire Funda Şahin, Esin Tufan, Ayşe Duygu Erdem, Ahmet Erdem, Mehmet |
| description | This study aimed to compare the pregnancy outcomes of natural cycles (NC) and artificial cycles (AC) in patients undergoing endometrial preparation for frozen-thawed embryo transfer (FET).
This retrospective cohort study was conducted in a private infertility clinic between September 2016 and January 2021 and reviewed 1696 FET cycles. Among these FET cycles, endometrial preparation protocols that are performed as the NC (group 1) and AC (group 2) were analyzed. Outcome measures were live birth rates (LBR), clinical pregnancy rates (CPR), implantation rates (IR), and miscarriage rates (MR).
The mean serum estradiol level before progesterone supplementation was significantly higher in group 2, whereas endometrial thickness before progesterone supplementation was higher in group 1 (p0.05). Additionally, CPR and LBR were similar in groups 1 (39.2% and 32.8%) and 2 (37.3% and 28.5%) (p=0.517, p=0.134, respectively). Multivariate logistic regression analyses revealed that female age at embryo freezing time and the number of transferred embryos were predictable variables of live birth [odds ratio (OR): 0.970, confidence interval (CI): 0.948-0.991, p |
| doi_str_mv | 10.4274/tjod.galenos.2021.17981 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8966319</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2833266177</sourcerecordid><originalsourceid>FETCH-LOGICAL-i327t-2a89c14838d21ff8d6869e9783b7daf675615fd3a2b68fc845080a34e27defa53</originalsourceid><addsrcrecordid>eNpdkU1v1DAQhiMEolXpXwBLXLhkiT_iDw5Iq6VApZW4wDmajcetV4692E6r5dcTxNICp5nRPHr0jqZpXtFuJZgSb-s-2dUNBIyprFjH6Ioqo-mT5pxRYVrDeff0oWfsrLksZd91HdVKGcqeN2e854Izqs6beZOmA2RfUiTJkQh1zhAIREsgV-_86JdxPI4BC_GRuJx-YGzrLdyjJTjt8jGRmiEWh_kdWZOMNadywLH6O1w8EI7Fl19uKo08mV40zxyEgpenetF8-3j1dfO53X75dL1Zb1vPmaotA21GKjTXllHntJVaGjRK852y4KTqJe2d5cB2UrtRi77THXCBTFl00POL5v1v72HeTWhHjEvUMByynyAfhwR--HcT_e1wk-4GbaTk1CyCNydBTt9nLHWYfBkxBIiY5jIwKQSXrON8QV__h-7TnJf7F0pzzqSkSj0KvUUIKQYf8RG8_nC13g60p70RC_ry7_APqf88j_8EjWSg_A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2833266177</pqid></control><display><type>article</type><title>Comparison of natural and artificial cycles in frozen-thawed embryo transfer: A retrospective analysis of 1696 cycles</title><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Demirdağ, Erhan ; Güler, İsmail ; Cevher Akdulum, Münire Funda ; Şahin, Esin ; Tufan, Ayşe Duygu ; Erdem, Ahmet ; Erdem, Mehmet</creator><contributor>Çalışkan,Eray</contributor><creatorcontrib>Demirdağ, Erhan ; Güler, İsmail ; Cevher Akdulum, Münire Funda ; Şahin, Esin ; Tufan, Ayşe Duygu ; Erdem, Ahmet ; Erdem, Mehmet ; Çalışkan,Eray</creatorcontrib><description>This study aimed to compare the pregnancy outcomes of natural cycles (NC) and artificial cycles (AC) in patients undergoing endometrial preparation for frozen-thawed embryo transfer (FET).
This retrospective cohort study was conducted in a private infertility clinic between September 2016 and January 2021 and reviewed 1696 FET cycles. Among these FET cycles, endometrial preparation protocols that are performed as the NC (group 1) and AC (group 2) were analyzed. Outcome measures were live birth rates (LBR), clinical pregnancy rates (CPR), implantation rates (IR), and miscarriage rates (MR).
The mean serum estradiol level before progesterone supplementation was significantly higher in group 2, whereas endometrial thickness before progesterone supplementation was higher in group 1 (p<0.05). The mean number of transferred embryos and embryo quality score rates regarding cleavage and blastocyst stages were similar in both groups. The IR and MR were similar between groups (p>0.05). Additionally, CPR and LBR were similar in groups 1 (39.2% and 32.8%) and 2 (37.3% and 28.5%) (p=0.517, p=0.134, respectively). Multivariate logistic regression analyses revealed that female age at embryo freezing time and the number of transferred embryos were predictable variables of live birth [odds ratio (OR): 0.970, confidence interval (CI): 0.948-0.991, p<0.05, and OR: 1.359, CI: 1.038-1.780, p<0.05, respectively].
Suitable endometrial preparation is essential to obtain successful pregnancy rates; however, no superiority was determined in NC or AC protocols in frozen-thawed cycles. One of these protocols may be performed depending on menstrual regularity and clinical experience.</description><identifier>ISSN: 2149-9322</identifier><identifier>EISSN: 2149-9330</identifier><identifier>DOI: 10.4274/tjod.galenos.2021.17981</identifier><identifier>PMID: 35343217</identifier><language>eng</language><publisher>Turkey: Türk Jinekoloji ve Obstetrik Derneği</publisher><subject>Clinical Investigation ; Cryopreservation ; Embryos ; Endometrium ; Fetuses ; Infertility ; Kadın Hastalıkları ; Menstruation ; Miscarriage ; Morphology ; Ovulation ; Pregnancy ; Regression analysis ; Tıp ; Ultrasonic imaging ; Vagina</subject><ispartof>Turkish journal of obstetrics and gynecology, 2022-03, Vol.19 (1), p.28-34</ispartof><rights>Copyright 2022 by Turkish Society of Obstetrics and Gynecology Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing House.</rights><rights>2022. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright 2022 by Turkish Society of Obstetrics and Gynecology | Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing House. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-2285-7112 ; 0000-0002-6509-1949 ; 0000-0002-4847-8404 ; 0000-0002-8098-2483 ; 0000-0002-1939-7138 ; 0000-0001-9944-6894 ; 0000-0003-4599-3854</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966319/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966319/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35343217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Çalışkan,Eray</contributor><creatorcontrib>Demirdağ, Erhan</creatorcontrib><creatorcontrib>Güler, İsmail</creatorcontrib><creatorcontrib>Cevher Akdulum, Münire Funda</creatorcontrib><creatorcontrib>Şahin, Esin</creatorcontrib><creatorcontrib>Tufan, Ayşe Duygu</creatorcontrib><creatorcontrib>Erdem, Ahmet</creatorcontrib><creatorcontrib>Erdem, Mehmet</creatorcontrib><title>Comparison of natural and artificial cycles in frozen-thawed embryo transfer: A retrospective analysis of 1696 cycles</title><title>Turkish journal of obstetrics and gynecology</title><addtitle>Turk J Obstet Gynecol</addtitle><description>This study aimed to compare the pregnancy outcomes of natural cycles (NC) and artificial cycles (AC) in patients undergoing endometrial preparation for frozen-thawed embryo transfer (FET).
This retrospective cohort study was conducted in a private infertility clinic between September 2016 and January 2021 and reviewed 1696 FET cycles. Among these FET cycles, endometrial preparation protocols that are performed as the NC (group 1) and AC (group 2) were analyzed. Outcome measures were live birth rates (LBR), clinical pregnancy rates (CPR), implantation rates (IR), and miscarriage rates (MR).
The mean serum estradiol level before progesterone supplementation was significantly higher in group 2, whereas endometrial thickness before progesterone supplementation was higher in group 1 (p<0.05). The mean number of transferred embryos and embryo quality score rates regarding cleavage and blastocyst stages were similar in both groups. The IR and MR were similar between groups (p>0.05). Additionally, CPR and LBR were similar in groups 1 (39.2% and 32.8%) and 2 (37.3% and 28.5%) (p=0.517, p=0.134, respectively). Multivariate logistic regression analyses revealed that female age at embryo freezing time and the number of transferred embryos were predictable variables of live birth [odds ratio (OR): 0.970, confidence interval (CI): 0.948-0.991, p<0.05, and OR: 1.359, CI: 1.038-1.780, p<0.05, respectively].
Suitable endometrial preparation is essential to obtain successful pregnancy rates; however, no superiority was determined in NC or AC protocols in frozen-thawed cycles. One of these protocols may be performed depending on menstrual regularity and clinical experience.</description><subject>Clinical Investigation</subject><subject>Cryopreservation</subject><subject>Embryos</subject><subject>Endometrium</subject><subject>Fetuses</subject><subject>Infertility</subject><subject>Kadın Hastalıkları</subject><subject>Menstruation</subject><subject>Miscarriage</subject><subject>Morphology</subject><subject>Ovulation</subject><subject>Pregnancy</subject><subject>Regression analysis</subject><subject>Tıp</subject><subject>Ultrasonic imaging</subject><subject>Vagina</subject><issn>2149-9322</issn><issn>2149-9330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkU1v1DAQhiMEolXpXwBLXLhkiT_iDw5Iq6VApZW4wDmajcetV4692E6r5dcTxNICp5nRPHr0jqZpXtFuJZgSb-s-2dUNBIyprFjH6Ioqo-mT5pxRYVrDeff0oWfsrLksZd91HdVKGcqeN2e854Izqs6beZOmA2RfUiTJkQh1zhAIREsgV-_86JdxPI4BC_GRuJx-YGzrLdyjJTjt8jGRmiEWh_kdWZOMNadywLH6O1w8EI7Fl19uKo08mV40zxyEgpenetF8-3j1dfO53X75dL1Zb1vPmaotA21GKjTXllHntJVaGjRK852y4KTqJe2d5cB2UrtRi77THXCBTFl00POL5v1v72HeTWhHjEvUMByynyAfhwR--HcT_e1wk-4GbaTk1CyCNydBTt9nLHWYfBkxBIiY5jIwKQSXrON8QV__h-7TnJf7F0pzzqSkSj0KvUUIKQYf8RG8_nC13g60p70RC_ry7_APqf88j_8EjWSg_A</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Demirdağ, Erhan</creator><creator>Güler, İsmail</creator><creator>Cevher Akdulum, Münire Funda</creator><creator>Şahin, Esin</creator><creator>Tufan, Ayşe Duygu</creator><creator>Erdem, Ahmet</creator><creator>Erdem, Mehmet</creator><general>Türk Jinekoloji ve Obstetrik Derneği</general><general>Galenos Publishing House</general><general>Galenos Publishing</general><scope>NPM</scope><scope>IEBAR</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2285-7112</orcidid><orcidid>https://orcid.org/0000-0002-6509-1949</orcidid><orcidid>https://orcid.org/0000-0002-4847-8404</orcidid><orcidid>https://orcid.org/0000-0002-8098-2483</orcidid><orcidid>https://orcid.org/0000-0002-1939-7138</orcidid><orcidid>https://orcid.org/0000-0001-9944-6894</orcidid><orcidid>https://orcid.org/0000-0003-4599-3854</orcidid></search><sort><creationdate>20220301</creationdate><title>Comparison of natural and artificial cycles in frozen-thawed embryo transfer: A retrospective analysis of 1696 cycles</title><author>Demirdağ, Erhan ; 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This retrospective cohort study was conducted in a private infertility clinic between September 2016 and January 2021 and reviewed 1696 FET cycles. Among these FET cycles, endometrial preparation protocols that are performed as the NC (group 1) and AC (group 2) were analyzed. Outcome measures were live birth rates (LBR), clinical pregnancy rates (CPR), implantation rates (IR), and miscarriage rates (MR).
The mean serum estradiol level before progesterone supplementation was significantly higher in group 2, whereas endometrial thickness before progesterone supplementation was higher in group 1 (p<0.05). The mean number of transferred embryos and embryo quality score rates regarding cleavage and blastocyst stages were similar in both groups. The IR and MR were similar between groups (p>0.05). Additionally, CPR and LBR were similar in groups 1 (39.2% and 32.8%) and 2 (37.3% and 28.5%) (p=0.517, p=0.134, respectively). Multivariate logistic regression analyses revealed that female age at embryo freezing time and the number of transferred embryos were predictable variables of live birth [odds ratio (OR): 0.970, confidence interval (CI): 0.948-0.991, p<0.05, and OR: 1.359, CI: 1.038-1.780, p<0.05, respectively].
Suitable endometrial preparation is essential to obtain successful pregnancy rates; however, no superiority was determined in NC or AC protocols in frozen-thawed cycles. One of these protocols may be performed depending on menstrual regularity and clinical experience.</abstract><cop>Turkey</cop><pub>Türk Jinekoloji ve Obstetrik Derneği</pub><pmid>35343217</pmid><doi>10.4274/tjod.galenos.2021.17981</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2285-7112</orcidid><orcidid>https://orcid.org/0000-0002-6509-1949</orcidid><orcidid>https://orcid.org/0000-0002-4847-8404</orcidid><orcidid>https://orcid.org/0000-0002-8098-2483</orcidid><orcidid>https://orcid.org/0000-0002-1939-7138</orcidid><orcidid>https://orcid.org/0000-0001-9944-6894</orcidid><orcidid>https://orcid.org/0000-0003-4599-3854</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Turkish journal of obstetrics and gynecology, 2022-03, Vol.19 (1), p.28-34 |
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| source | PubMed Central; Alma/SFX Local Collection |
| subjects | Clinical Investigation Cryopreservation Embryos Endometrium Fetuses Infertility Kadın Hastalıkları Menstruation Miscarriage Morphology Ovulation Pregnancy Regression analysis Tıp Ultrasonic imaging Vagina |
| title | Comparison of natural and artificial cycles in frozen-thawed embryo transfer: A retrospective analysis of 1696 cycles |
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