Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts

We have studied the in vivo activity of the new experimental triazole derivative SCH 56592 (posaconazole) against a variety of strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi, the causative agent of Chagas' disease, in both immunocompetent and immunosuppressed murine hosts....

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2000, Vol.44 (1), p.150-155
Hauptverfasser:	MOLINA, J, MARTINS-FILHO, O, BRENER, Z, ROMANHA, A. J, LOEBENBERG, D, URBINA, J. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Benznidazole Biological and medical sciences Chagas Disease - drug therapy Chronic Disease Drug Resistance Experimental Therapeutics Female Immunocompetence Immunosuppression Therapy Medical sciences Mice Nifurtimox Nitroimidazoles - pharmacology Pharmacology. Drug treatments SCH-56592 Triazoles - pharmacology Trypanocidal Agents - pharmacology Trypanosoma cruzi Trypanosoma cruzi - drug effects
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