Curcumin and Its Analogs as a Therapeutic Strategy in Infections Caused by RNA Genome Viruses
The use of natural resources for the prevention and treatment of diseases considered fatal to humanity has evolved. Several medicinal plants have nutritional and pharmacological potential in the prevention and treatment of viral infections, among them, turmeric, which is recognized for its biologica...
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| Veröffentlicht in: | Food and environmental virology 2022-06, Vol.14 (2), p.120-137 |
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| creator | Ferreira, Leide Lene C. Abreu, Marina P. Costa, Camila B. Leda, Paulo O. Behrens, Maria Dutra dos Santos, Elisabete Pereira |
| description | The use of natural resources for the prevention and treatment of diseases considered fatal to humanity has evolved. Several medicinal plants have nutritional and pharmacological potential in the prevention and treatment of viral infections, among them, turmeric, which is recognized for its biological properties associated with curcuminoids, mainly represented by curcumin, and found mostly in rhizomes. The purpose of this review was to compile the pharmacological activities of curcumin and its analogs, aiming at stimulating their use as a therapeutic strategy to treat infections caused by RNA genome viruses. We revisited its historical application as an anti-inflammatory, antioxidant, and antiviral agent that combined with low toxicity, motivated research against viruses affecting the population for decades. Most findings concentrate particularly on arboviruses, HIV, and the recent SARS-CoV-2. As one of the main conclusions, associating curcuminoids with nanomaterials increases solubility, bioavailability, and antiviral effects, characterized by blocking the entry of the virus into the cell or by inhibiting key enzymes in viral replication and transcription. |
| doi_str_mv | 10.1007/s12560-022-09514-3 |
| format | Article |
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Several medicinal plants have nutritional and pharmacological potential in the prevention and treatment of viral infections, among them, turmeric, which is recognized for its biological properties associated with curcuminoids, mainly represented by curcumin, and found mostly in rhizomes. The purpose of this review was to compile the pharmacological activities of curcumin and its analogs, aiming at stimulating their use as a therapeutic strategy to treat infections caused by RNA genome viruses. We revisited its historical application as an anti-inflammatory, antioxidant, and antiviral agent that combined with low toxicity, motivated research against viruses affecting the population for decades. Most findings concentrate particularly on arboviruses, HIV, and the recent SARS-CoV-2. 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Several medicinal plants have nutritional and pharmacological potential in the prevention and treatment of viral infections, among them, turmeric, which is recognized for its biological properties associated with curcuminoids, mainly represented by curcumin, and found mostly in rhizomes. The purpose of this review was to compile the pharmacological activities of curcumin and its analogs, aiming at stimulating their use as a therapeutic strategy to treat infections caused by RNA genome viruses. We revisited its historical application as an anti-inflammatory, antioxidant, and antiviral agent that combined with low toxicity, motivated research against viruses affecting the population for decades. Most findings concentrate particularly on arboviruses, HIV, and the recent SARS-CoV-2. 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| subjects | Analogs Antioxidants Antiviral Agents - pharmacology Aquatic plants Bioavailability Biological properties Biomedical and Life Sciences Biomedicine Chemistry/Food Science COVID-19 Drug Treatment Curcumin Curcumin - pharmacology Diarylheptanoids Food Science Genomes Herbal medicine HIV Human immunodeficiency virus Humans Infections Inflammation Medicinal plants Nanomaterials Nanotechnology Natural resources Pharmacology Prevention Review Paper Rhizomes RNA RNA viruses SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Toxicity Viral diseases Viral infections Virology Viruses |
| title | Curcumin and Its Analogs as a Therapeutic Strategy in Infections Caused by RNA Genome Viruses |
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