Ulcerative Colitis-Induced Colorectal Carcinoma: A Deleterious Concatenation
Inflammatory bowel disease (IBD) is a chronic inflammatory gastrointestinal ailment that encompasses Crohn's disease (CD) and ulcerative colitis (UC). UC is an idiopathic, chronic inflammatory condition of the colonic mucosa that begins in the rectum and progresses proximally in a continuous wa...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2022-02, Vol.14 (2), p.e22636-e22636 |
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| creator | Rivera, Ana P Flores Monar, Gabriela Vanessa Islam, Hamza Puttagunta, Sri Madhurima Islam, Rabia Kundu, Sumana Jha, Surajkumar B Sange, Ibrahim |
| description | Inflammatory bowel disease (IBD) is a chronic inflammatory gastrointestinal ailment that encompasses Crohn's disease (CD) and ulcerative colitis (UC). UC is an idiopathic, chronic inflammatory condition of the colonic mucosa that begins in the rectum and progresses proximally in a continuous way over a portion of the entire colon. Chronic inflammation is linked to cancer, and IBD-related chronic colonic inflammation raises the risk of colorectal cancer. Chronic inflammation has been linked to cancer, and chronic colonic inflammation caused by IBD increases the risk of colorectal cancer (CRC). When CRC arises in people with IBD, unlike sporadic CRC, the lesions are difficult to identify due to mucosal alterations produced by inflammation. The total prevalence of IBD-associated CRC is increasing due to the rapidly increasing frequency of IBD. Screening and surveillance colonoscopy in IBD patients is considered to allow for the early diagnosis of dysplasia and cancer, improving the prognosis of IBD-related CRC by giving patients proactive therapy. This article has reviewed literature pertaining to the mechanisms related to CRC development in UC and its clinical and therapeutic implications. |
| doi_str_mv | 10.7759/cureus.22636 |
| format | Article |
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UC is an idiopathic, chronic inflammatory condition of the colonic mucosa that begins in the rectum and progresses proximally in a continuous way over a portion of the entire colon. Chronic inflammation is linked to cancer, and IBD-related chronic colonic inflammation raises the risk of colorectal cancer. Chronic inflammation has been linked to cancer, and chronic colonic inflammation caused by IBD increases the risk of colorectal cancer (CRC). When CRC arises in people with IBD, unlike sporadic CRC, the lesions are difficult to identify due to mucosal alterations produced by inflammation. The total prevalence of IBD-associated CRC is increasing due to the rapidly increasing frequency of IBD. Screening and surveillance colonoscopy in IBD patients is considered to allow for the early diagnosis of dysplasia and cancer, improving the prognosis of IBD-related CRC by giving patients proactive therapy. This article has reviewed literature pertaining to the mechanisms related to CRC development in UC and its clinical and therapeutic implications.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.22636</identifier><identifier>PMID: 35371788</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Antibiotics ; Cancer ; Chronic illnesses ; Colon ; Colorectal cancer ; Crohn's disease ; Gastroenterology ; Inflammation ; Inflammatory bowel disease ; Inflammatory diseases ; Internal Medicine ; Large intestine ; Microbiota ; Oncology ; Pathogenesis ; Pathophysiology ; Patients ; Population ; Rectum ; Remission (Medicine) ; Steroids</subject><ispartof>Curēus (Palo Alto, CA), 2022-02, Vol.14 (2), p.e22636-e22636</ispartof><rights>Copyright © 2022, Rivera et al.</rights><rights>Copyright © 2022, Rivera et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2022, Rivera et al. 2022 Rivera et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-92e6377efb6b7ad692652bf74fc8e068d49a37ee07ba160bda79be58aa13ef723</citedby><cites>FETCH-LOGICAL-c342t-92e6377efb6b7ad692652bf74fc8e068d49a37ee07ba160bda79be58aa13ef723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959421/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959421/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35371788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rivera, Ana P</creatorcontrib><creatorcontrib>Flores Monar, Gabriela Vanessa</creatorcontrib><creatorcontrib>Islam, Hamza</creatorcontrib><creatorcontrib>Puttagunta, Sri Madhurima</creatorcontrib><creatorcontrib>Islam, Rabia</creatorcontrib><creatorcontrib>Kundu, Sumana</creatorcontrib><creatorcontrib>Jha, Surajkumar B</creatorcontrib><creatorcontrib>Sange, Ibrahim</creatorcontrib><title>Ulcerative Colitis-Induced Colorectal Carcinoma: A Deleterious Concatenation</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Inflammatory bowel disease (IBD) is a chronic inflammatory gastrointestinal ailment that encompasses Crohn's disease (CD) and ulcerative colitis (UC). UC is an idiopathic, chronic inflammatory condition of the colonic mucosa that begins in the rectum and progresses proximally in a continuous way over a portion of the entire colon. Chronic inflammation is linked to cancer, and IBD-related chronic colonic inflammation raises the risk of colorectal cancer. Chronic inflammation has been linked to cancer, and chronic colonic inflammation caused by IBD increases the risk of colorectal cancer (CRC). When CRC arises in people with IBD, unlike sporadic CRC, the lesions are difficult to identify due to mucosal alterations produced by inflammation. The total prevalence of IBD-associated CRC is increasing due to the rapidly increasing frequency of IBD. Screening and surveillance colonoscopy in IBD patients is considered to allow for the early diagnosis of dysplasia and cancer, improving the prognosis of IBD-related CRC by giving patients proactive therapy. This article has reviewed literature pertaining to the mechanisms related to CRC development in UC and its clinical and therapeutic implications.</description><subject>Antibiotics</subject><subject>Cancer</subject><subject>Chronic illnesses</subject><subject>Colon</subject><subject>Colorectal cancer</subject><subject>Crohn's disease</subject><subject>Gastroenterology</subject><subject>Inflammation</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory diseases</subject><subject>Internal Medicine</subject><subject>Large intestine</subject><subject>Microbiota</subject><subject>Oncology</subject><subject>Pathogenesis</subject><subject>Pathophysiology</subject><subject>Patients</subject><subject>Population</subject><subject>Rectum</subject><subject>Remission (Medicine)</subject><subject>Steroids</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkUtLxDAURoMoKjo711Jw48KOebR5uBCG-hoYcOOsQ5reaqSTaNIK_ns7joq6yg33cLgfH0JHBE-FKNW5HSIMaUopZ3wL7VPCZS6JLLZ_zXtoktIzxphgQbHAu2iPlUwQIeU-Wiw7C9H07g2yKnSudymf-2aw0Kz_IYLtTZdVJlrnw8pcZLPsCjroIbowpJHx1vTgR0Pwh2inNV2Cydd7gJY31w_VXb64v51Xs0VuWUH7XFHgTAhoa14L03BFeUnrVhStlYC5bAplmADAojaE47oxQtVQSmMIg1ZQdoAuN96XoV5BY8H30XT6JbqVie86GKf_brx70o_hTUtVqoKSUXD6JYjhdYDU65VLFrrOeBhTacoLrpiiao2e_EOfwxD9GG-kSsEZKWQ5UmcbysaQUoT25xiC9bopvWlKfzY14se_A_zA372wD81BkSU</recordid><startdate>20220226</startdate><enddate>20220226</enddate><creator>Rivera, Ana P</creator><creator>Flores Monar, Gabriela Vanessa</creator><creator>Islam, Hamza</creator><creator>Puttagunta, Sri Madhurima</creator><creator>Islam, Rabia</creator><creator>Kundu, Sumana</creator><creator>Jha, Surajkumar B</creator><creator>Sange, Ibrahim</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220226</creationdate><title>Ulcerative Colitis-Induced Colorectal Carcinoma: A Deleterious Concatenation</title><author>Rivera, Ana P ; 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| subjects | Antibiotics Cancer Chronic illnesses Colon Colorectal cancer Crohn's disease Gastroenterology Inflammation Inflammatory bowel disease Inflammatory diseases Internal Medicine Large intestine Microbiota Oncology Pathogenesis Pathophysiology Patients Population Rectum Remission (Medicine) Steroids |
| title | Ulcerative Colitis-Induced Colorectal Carcinoma: A Deleterious Concatenation |
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