Hypothesis-Driven, Structure-Based Design in Photopharmacology: The Case of eDHFR Inhibitors

Photopharmacology uses light to regulate the biological activity of drugs. This precise control is obtained through the incorporation of molecular photoswitches into bioactive molecules. A major challenge for photopharmacology is the rational design of photoswitchable drugs that show light-induced a...

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Veröffentlicht in:	Journal of medicinal chemistry 2022-03, Vol.65 (6), p.4798-4817
Hauptverfasser:	Kobauri, Piermichele, Galenkamp, Nicole S, Schulte, Albert M, de Vries, Jisk, Simeth, Nadja A, Maglia, Giovanni, Thallmair, Sebastian, Kolarski, Dušan, Szymanski, Wiktor, Feringa, Ben L
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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