Sexually dimorphic associations between prenatal blood lead exposure and performance on a behavioral testing battery in children
Associations between lead (Pb) and neurodevelopment have been studied widely in the context of global measures of cognitive function, such as IQ. Operant test batteries consist of behavioral tasks that can be used to target discrete cognitive and behavioral mechanisms, which contribute to global cog...
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| Veröffentlicht in: | Neurotoxicology and teratology 2022-03, Vol.90, p.107075-107075, Article 107075 |
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| creator | Merced-Nieves, Francheska M. Chelonis, John Pantic, Ivan Schnass, Lourdes Téllez-Rojo, Martha M. Braun, Joseph M. Paule, Merle G. Wright, Rosalind J. Wright, Robert O. Curtin, Paul |
| description | Associations between lead (Pb) and neurodevelopment have been studied widely in the context of global measures of cognitive function, such as IQ. Operant test batteries consist of behavioral tasks that can be used to target discrete cognitive and behavioral mechanisms, which contribute to global cognitive faculties.
The goals of this study were to identify Pb-associated deficits in cognitive development and determine the underlying mechanisms involved, utilizing an operant test battery. We evaluated effect modification by child sex.
This study utilized data from a prospective cohort in Mexico City. We included 549 participants aged 6-to-7 years with complete data on prenatal blood Pb measurements, Operant Test Battery (OTB) tasks, and demographic covariates. General linear models were used to examine the association of Pb levels at each prenatal timepoint and OTB performance. Effect modification by child sex was evaluated using 2-way interaction terms.
In three of the operant tasks, we observed that higher late-pregnancy blood Pb concentrations were associated with greater response latencies. In the temporal processing task, we observed that higher late-pregnancy Pb exposure was associated with worse overall task performance. Further, in two operant tasks, the effects of Pb were dependent on the sex of the child, such that the effects of Pb were more pronounced in females in the condition position responding task, but stronger in males in the temporal processing task.
Our results suggest that prenatal Pb concentrations yield broad dysregulation of executive functions, which can be attributed to dysregulation of temporal processing. In addition, we observed sex differences in two operant tasks suggesting that some Pb effects on neurocognitive function may be sexually dimorphic.
•Operant testing procedures were used to attribute lead-associated deficits to discrete cognitive mechanisms•Higher prenatal lead (Pb) concentrations yield broad dysregulation of executive functions•Prenatal Pb concentrations dysregulations can be, in part, attributed to dysregulation of temporal processing•Sex differences were observed in two operant tasks suggesting that some Pb effectsmay be sexually dimorphic |
| doi_str_mv | 10.1016/j.ntt.2022.107075 |
| format | Article |
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The goals of this study were to identify Pb-associated deficits in cognitive development and determine the underlying mechanisms involved, utilizing an operant test battery. We evaluated effect modification by child sex.
This study utilized data from a prospective cohort in Mexico City. We included 549 participants aged 6-to-7 years with complete data on prenatal blood Pb measurements, Operant Test Battery (OTB) tasks, and demographic covariates. General linear models were used to examine the association of Pb levels at each prenatal timepoint and OTB performance. Effect modification by child sex was evaluated using 2-way interaction terms.
In three of the operant tasks, we observed that higher late-pregnancy blood Pb concentrations were associated with greater response latencies. In the temporal processing task, we observed that higher late-pregnancy Pb exposure was associated with worse overall task performance. Further, in two operant tasks, the effects of Pb were dependent on the sex of the child, such that the effects of Pb were more pronounced in females in the condition position responding task, but stronger in males in the temporal processing task.
Our results suggest that prenatal Pb concentrations yield broad dysregulation of executive functions, which can be attributed to dysregulation of temporal processing. In addition, we observed sex differences in two operant tasks suggesting that some Pb effects on neurocognitive function may be sexually dimorphic.
•Operant testing procedures were used to attribute lead-associated deficits to discrete cognitive mechanisms•Higher prenatal lead (Pb) concentrations yield broad dysregulation of executive functions•Prenatal Pb concentrations dysregulations can be, in part, attributed to dysregulation of temporal processing•Sex differences were observed in two operant tasks suggesting that some Pb effectsmay be sexually dimorphic</description><identifier>ISSN: 0892-0362</identifier><identifier>EISSN: 1872-9738</identifier><identifier>DOI: 10.1016/j.ntt.2022.107075</identifier><identifier>PMID: 35108597</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Behavior ; Child ; Cognition ; Cohort Studies ; Female ; Humans ; Lead ; Lead - toxicity ; Male ; Neurodevelopment ; Operant task ; Pregnancy ; Prenatal Exposure Delayed Effects ; Prospective Studies ; Sex Characteristics ; Sexually dimorphic</subject><ispartof>Neurotoxicology and teratology, 2022-03, Vol.90, p.107075-107075, Article 107075</ispartof><rights>2022 Elsevier Inc.</rights><rights>Copyright © 2022 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-7ff91f8cc68110a07dbbf2ab251b72ccc372afa86d394a6643592ac7e49e3db93</citedby><cites>FETCH-LOGICAL-c451t-7ff91f8cc68110a07dbbf2ab251b72ccc372afa86d394a6643592ac7e49e3db93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0892036222000137$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35108597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Merced-Nieves, Francheska M.</creatorcontrib><creatorcontrib>Chelonis, John</creatorcontrib><creatorcontrib>Pantic, Ivan</creatorcontrib><creatorcontrib>Schnass, Lourdes</creatorcontrib><creatorcontrib>Téllez-Rojo, Martha M.</creatorcontrib><creatorcontrib>Braun, Joseph M.</creatorcontrib><creatorcontrib>Paule, Merle G.</creatorcontrib><creatorcontrib>Wright, Rosalind J.</creatorcontrib><creatorcontrib>Wright, Robert O.</creatorcontrib><creatorcontrib>Curtin, Paul</creatorcontrib><title>Sexually dimorphic associations between prenatal blood lead exposure and performance on a behavioral testing battery in children</title><title>Neurotoxicology and teratology</title><addtitle>Neurotoxicol Teratol</addtitle><description>Associations between lead (Pb) and neurodevelopment have been studied widely in the context of global measures of cognitive function, such as IQ. Operant test batteries consist of behavioral tasks that can be used to target discrete cognitive and behavioral mechanisms, which contribute to global cognitive faculties.
The goals of this study were to identify Pb-associated deficits in cognitive development and determine the underlying mechanisms involved, utilizing an operant test battery. We evaluated effect modification by child sex.
This study utilized data from a prospective cohort in Mexico City. We included 549 participants aged 6-to-7 years with complete data on prenatal blood Pb measurements, Operant Test Battery (OTB) tasks, and demographic covariates. General linear models were used to examine the association of Pb levels at each prenatal timepoint and OTB performance. Effect modification by child sex was evaluated using 2-way interaction terms.
In three of the operant tasks, we observed that higher late-pregnancy blood Pb concentrations were associated with greater response latencies. In the temporal processing task, we observed that higher late-pregnancy Pb exposure was associated with worse overall task performance. Further, in two operant tasks, the effects of Pb were dependent on the sex of the child, such that the effects of Pb were more pronounced in females in the condition position responding task, but stronger in males in the temporal processing task.
Our results suggest that prenatal Pb concentrations yield broad dysregulation of executive functions, which can be attributed to dysregulation of temporal processing. In addition, we observed sex differences in two operant tasks suggesting that some Pb effects on neurocognitive function may be sexually dimorphic.
•Operant testing procedures were used to attribute lead-associated deficits to discrete cognitive mechanisms•Higher prenatal lead (Pb) concentrations yield broad dysregulation of executive functions•Prenatal Pb concentrations dysregulations can be, in part, attributed to dysregulation of temporal processing•Sex differences were observed in two operant tasks suggesting that some Pb effectsmay be sexually dimorphic</description><subject>Behavior</subject><subject>Child</subject><subject>Cognition</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Lead</subject><subject>Lead - toxicity</subject><subject>Male</subject><subject>Neurodevelopment</subject><subject>Operant task</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Prospective Studies</subject><subject>Sex Characteristics</subject><subject>Sexually dimorphic</subject><issn>0892-0362</issn><issn>1872-9738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc-KFDEQh4Mo7rj6AF4kL9Cz-TPd6SAIsqgrLHhQz6GSVO9k6EmaJDPu3Hx0s4wuevEUQur7UlU_Ql5ztuaMD1e7dax1LZgQ7a6Y6p-QFR-V6LSS41OyYqMWHZODuCAvStkxxtTA2XNyIXvOxl6rFfn5Fe8PMM8n6sM-5WUbHIVSkgtQQ4qFWqw_ECNdMkaoMFM7p-TpjOAp3i-pHDJSiJ4umKeU9xAd0hQpNHILx5ByYyqWGuIdtVAr5hMNkbptmH1zviTPJpgLvvp9XpLvHz98u77pbr98-nz9_rZzm57XTk2T5tPo3DByzoApb-0kwIqeWyWcc1IJmGAcvNQbGIaN7LUAp3CjUXqr5SV5d_YuB7tH7zDW1plZcthDPpkEwfz7EsPW3KWjGXWvFJdNwM8Cl1MpGadHljPzEIfZmRaHeYjDnONozJu_P30k_uy_Fbw9F2Ab_Rgwm-ICthX6kNFV41P4j_4X4yWgmA</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Merced-Nieves, Francheska M.</creator><creator>Chelonis, John</creator><creator>Pantic, Ivan</creator><creator>Schnass, Lourdes</creator><creator>Téllez-Rojo, Martha M.</creator><creator>Braun, Joseph M.</creator><creator>Paule, Merle G.</creator><creator>Wright, Rosalind J.</creator><creator>Wright, Robert O.</creator><creator>Curtin, Paul</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20220301</creationdate><title>Sexually dimorphic associations between prenatal blood lead exposure and performance on a behavioral testing battery in children</title><author>Merced-Nieves, Francheska M. ; Chelonis, John ; Pantic, Ivan ; Schnass, Lourdes ; Téllez-Rojo, Martha M. ; Braun, Joseph M. ; Paule, Merle G. ; Wright, Rosalind J. ; Wright, Robert O. ; Curtin, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-7ff91f8cc68110a07dbbf2ab251b72ccc372afa86d394a6643592ac7e49e3db93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Behavior</topic><topic>Child</topic><topic>Cognition</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Lead</topic><topic>Lead - toxicity</topic><topic>Male</topic><topic>Neurodevelopment</topic><topic>Operant task</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Prospective Studies</topic><topic>Sex Characteristics</topic><topic>Sexually dimorphic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Merced-Nieves, Francheska M.</creatorcontrib><creatorcontrib>Chelonis, John</creatorcontrib><creatorcontrib>Pantic, Ivan</creatorcontrib><creatorcontrib>Schnass, Lourdes</creatorcontrib><creatorcontrib>Téllez-Rojo, Martha M.</creatorcontrib><creatorcontrib>Braun, Joseph M.</creatorcontrib><creatorcontrib>Paule, Merle G.</creatorcontrib><creatorcontrib>Wright, Rosalind J.</creatorcontrib><creatorcontrib>Wright, Robert O.</creatorcontrib><creatorcontrib>Curtin, Paul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurotoxicology and teratology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Merced-Nieves, Francheska M.</au><au>Chelonis, John</au><au>Pantic, Ivan</au><au>Schnass, Lourdes</au><au>Téllez-Rojo, Martha M.</au><au>Braun, Joseph M.</au><au>Paule, Merle G.</au><au>Wright, Rosalind J.</au><au>Wright, Robert O.</au><au>Curtin, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sexually dimorphic associations between prenatal blood lead exposure and performance on a behavioral testing battery in children</atitle><jtitle>Neurotoxicology and teratology</jtitle><addtitle>Neurotoxicol Teratol</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>90</volume><spage>107075</spage><epage>107075</epage><pages>107075-107075</pages><artnum>107075</artnum><issn>0892-0362</issn><eissn>1872-9738</eissn><abstract>Associations between lead (Pb) and neurodevelopment have been studied widely in the context of global measures of cognitive function, such as IQ. Operant test batteries consist of behavioral tasks that can be used to target discrete cognitive and behavioral mechanisms, which contribute to global cognitive faculties.
The goals of this study were to identify Pb-associated deficits in cognitive development and determine the underlying mechanisms involved, utilizing an operant test battery. We evaluated effect modification by child sex.
This study utilized data from a prospective cohort in Mexico City. We included 549 participants aged 6-to-7 years with complete data on prenatal blood Pb measurements, Operant Test Battery (OTB) tasks, and demographic covariates. General linear models were used to examine the association of Pb levels at each prenatal timepoint and OTB performance. Effect modification by child sex was evaluated using 2-way interaction terms.
In three of the operant tasks, we observed that higher late-pregnancy blood Pb concentrations were associated with greater response latencies. In the temporal processing task, we observed that higher late-pregnancy Pb exposure was associated with worse overall task performance. Further, in two operant tasks, the effects of Pb were dependent on the sex of the child, such that the effects of Pb were more pronounced in females in the condition position responding task, but stronger in males in the temporal processing task.
Our results suggest that prenatal Pb concentrations yield broad dysregulation of executive functions, which can be attributed to dysregulation of temporal processing. In addition, we observed sex differences in two operant tasks suggesting that some Pb effects on neurocognitive function may be sexually dimorphic.
•Operant testing procedures were used to attribute lead-associated deficits to discrete cognitive mechanisms•Higher prenatal lead (Pb) concentrations yield broad dysregulation of executive functions•Prenatal Pb concentrations dysregulations can be, in part, attributed to dysregulation of temporal processing•Sex differences were observed in two operant tasks suggesting that some Pb effectsmay be sexually dimorphic</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>35108597</pmid><doi>10.1016/j.ntt.2022.107075</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Behavior Child Cognition Cohort Studies Female Humans Lead Lead - toxicity Male Neurodevelopment Operant task Pregnancy Prenatal Exposure Delayed Effects Prospective Studies Sex Characteristics Sexually dimorphic |
| title | Sexually dimorphic associations between prenatal blood lead exposure and performance on a behavioral testing battery in children |
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