The Hippo pathway effectors YAP and TAZ interact with EGF-like signaling to regulate expansion-related events in bovine cumulus cells in vitro

Purpose To determine if the inhibition of the interaction between the Hippo effector YAP or its transcriptional co-activator TAZ with the TEAD family of transcription factors is critical for the cumulus expansion–related events induced by the EGF network in cumulus-oocyte complexes (COCs). Method...

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Veröffentlicht in:	Journal of assisted reproduction and genetics 2022-02, Vol.39 (2), p.481-492
Hauptverfasser:	Koch, Júlia, Portela, Valério Marques, Dos Santos, Esdras Corrêa, Missio, Daniele, de Andrade, Leonardo Guedes, da Silva, Zigomar, Gasperin, Bernardo Garziera, Antoniazzi, Alfredo Quites, Gonçalves, Paulo Bayard Dias, Zamberlam, Gustavo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Connective tissue growth factor Cumulus Cells - metabolism Epidermal growth factor Epidermal Growth Factor - pharmacology Epidermal growth factor receptors Female Follicle-stimulating hormone Gynecology Hippo Signaling Pathway Human Genetics In Vitro Oocyte Maturation Techniques Kinases Laboratories Medicine Medicine & Public Health Oocytes - metabolism Ovaries Ovulation Proteins Reproductive Medicine Reproductive Physiology and Disease Signal Transduction Transcription factors Transcriptional Coactivator with PDZ-Binding Motif Proteins - metabolism YAP-Signaling Proteins - metabolism Yes-associated protein
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